AI5L7_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AI5L7_ARATH
• UniProt AC: Q9M7Q2
• Protein Name: ABSCISIC ACID-INSENSITIVE 5-like protein 7
• Gene Name: ABF4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 431
• Subcellular Localization: Nucleus .
• Protein Description: Functions as transcriptional activator in the ABA-inducible expression of rd29B. Binds specifically to the ABA-responsive element (ABRE) of the rd29B gene promoter..
• Protein Sequence: MGTHINFNNLGGGGHPGGEGSSNQMKPTGSVMPLARQSSVYSLTFDELQNTLGGPGKDFGSMNMDELLKSIWTAEEAQAMAMTSAPAATAVAQPGAGIPPPGGNLQRQGSLTLPRTISQKTVDEVWKCLITKDGNMEGSSGGGGESNVPPGRQQTLGEMTLEEFLFRAGVVREDNCVQQMGQVNGNNNNGFYGNSTAAGGLGFGFGQPNQNSITFNGTNDSMILNQPPGLGLKMGGTMQQQQQQQQLLQQQQQQMQQLNQPHPQQRLPQTIFPKQANVAFSAPVNITNKGFAGAANNSINNNNGLASYGGTGVTVAATSPGTSSAENNSLSPVPYVLNRGRRSNTGLEKVIERRQRRMIKNRESAARSRARKQAYTLELEAEIEKLKKTNQELQKKQAEMVEMQKNELKETSKRPWGSKRQCLRRTLTGPW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	MPLARQSSVYSLTFD CCCCCCCCEEEEEHH	19.41	-
41	Phosphorylation	LARQSSVYSLTFDEL CCCCCCEEEEEHHHH	10.42	22074104
42	Phosphorylation	ARQSSVYSLTFDELQ CCCCCEEEEEHHHHH	20.83	22074104
61	Phosphorylation	GPGKDFGSMNMDELL CCCCCCCCCCHHHHH	13.64	30291188
110	Phosphorylation	GNLQRQGSLTLPRTI CCCCCCCCEECCCCC	15.16	30291188
112	Phosphorylation	LQRQGSLTLPRTISQ CCCCCCEECCCCCCH	36.09	23776212
155	Phosphorylation	VPPGRQQTLGEMTLE CCCCCCCCCCCCCHH	28.52	-
426	Phosphorylation	KRQCLRRTLTGPW-- HHHHHHHHHCCCC--	23.41	30407730
428	Phosphorylation	QCLRRTLTGPW---- HHHHHHHCCCC----	40.35	30407730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
110	S	Phosphorylation	Kinase	CPK32	Q6NLQ6	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AI5L7_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AI5L7_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDPKW_ARATH	CPK32	physical	16299177
CDPKA_ARATH	CDPK1	physical	16299177
CDPKU_ARATH	CPK30	physical	16299177
ERF95_ARATH	AT3G23220	physical	22669746
ATB21_ARATH	HB21	physical	22669746
SRK2D_ARATH	SNRK2.2	physical	19947981
AI5L7_ARATH	ABF4	physical	19947981
AI5L6_ARATH	ABF3	physical	19947981
DRE2C_ARATH	DREB2C	physical	20395451
DRE2A_ARATH	DREB2A	physical	20395451
DRE1A_ARATH	DREB1A	physical	20395451
P2C75_ARATH	AHG1	physical	23007729
P2C37_ARATH	PP2CA	physical	23007729
AI5L4_ARATH	ABF1	physical	23007729
AI5L6_ARATH	ABF3	physical	23007729

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Arabidopsis calcium-dependent protein kinase AtCPK32 interacts withABF4, a transcriptional regulator of abscisic acid-responsive geneexpression, and modulates its activity.";
Choi H.-I., Park H.-J., Park J.H., Kim S., Im M.-Y., Seo H.-H.,Kim Y.-W., Hwang I., Kim S.Y.;
Plant Physiol. 139:1750-1761(2005).
Cited for: INTERACTION WITH CPK32, AND PHOSPHORYLATION AT SER-110 BY CPK32.
PubMed: 16299177