dbPTM

CDPKA_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDPKA_ARATH
UniProt AC	Q9M9V8
Protein Name	Calcium-dependent protein kinase 10
Gene Name	CPK10
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	545
Subcellular Localization	Membrane Lipid-anchor .
Protein Description	May play a role in signal transduction pathways that involve calcium as a second messenger. May be a positive regulator controlling stress signal transduction..
Protein Sequence	MGNCNACVRPDSKESKPSSKPKKPNRDRKLNPFAGDFTRSPAPIRVLKDVIPMSNQTQISDKYILGRELGRGEFGITYLCTDRETHEALACKSISKRKLRTAVDIEDVRREVAIMSTLPEHPNVVKLKASYEDNENVHLVMELCEGGELFDRIVARGHYTERAAAAVARTIAEVVMMCHSNGVMHRDLKPENFLFANKKENSPLKAIDFGLSVFFKPGDKFTEIVGSPYYMAPEVLKRDYGPGVDVWSAGVIIYILLCGVPPFWAETEQGVALAILRGVLDFKRDPWPQISESAKSLVKQMLDPDPTKRLTAQQVLAHPWIQNAKKAPNVPLGDIVRSRLKQFSMMNRFKKKVLRVIAEHLSIQEVEVIKNMFSLMDDDKDGKITYPELKAGLQKVGSQLGEPEIKMLMEVADVDGNGFLDYGEFVAVIIHLQKIENDELFKLAFMFFDKDGSTYIELDELREALADELGEPDASVLSDIMREVDTDKDGRINYDEFVTMMKAGTDWRKASRQYSRERFKSLSINLMKDGSLHLHDALTGQTVPV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGNCNACVR ------CCCCCCCCC	47.61	-
38	Phosphorylation	NPFAGDFTRSPAPIR CCCCCCCCCCCCCCE	34.67	-
227	Phosphorylation	KFTEIVGSPYYMAPE CHHHHCCCCCCCCHH	9.99	-
521	Phosphorylation	YSRERFKSLSINLMK HHHHHHHHCEEEEEC	25.33	25561503
523	Phosphorylation	RERFKSLSINLMKDG HHHHHHCEEEEECCC	19.27	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CDPKA_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CDPKA_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDPKA_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CALM1_ARATH	CAM1	physical	25233328
CALM4_ARATH	CAM1	physical	25233328

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CDPKA_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomics of early elicitor signaling inArabidopsis."; Benschop J.J., Mohammed S., O'Flaherty M., Heck A.J.R., Slijper M.,Menke F.L.H.; Mol. Cell. Proteomics 6:1198-1214(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-523, AND MASSSPECTROMETRY.	17317660 [Abstract]
"A phyloproteomic characterization of in vitro autophosphorylation incalcium-dependent protein kinases."; Hegeman A.D., Rodriguez M., Han B.W., Uno Y., Phillips G.N. Jr.,Hrabak E.M., Cushman J.C., Harper J.F., Harmon A.C., Sussman M.R.; Proteomics 6:3649-3664(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-38, AND MASSSPECTROMETRY.	16758442 [Abstract]