ADA2A_HUMAN - dbPTM
ADA2A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADA2A_HUMAN
UniProt AC P08913
Protein Name Alpha-2A adrenergic receptor
Gene Name ADRA2A
Organism Homo sapiens (Human).
Sequence Length 450
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol..
Protein Sequence MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10N-linked_GlycosylationSLQPDAGNASWNGTE
CCCCCCCCCCCCCCC		32.30UniProtKB CARBOHYD
14N-linked_GlycosylationDAGNASWNGTEAPGG
CCCCCCCCCCCCCCC		45.04UniProtKB CARBOHYD
25N-linked_GlycosylationAPGGGARATPYSLQV
CCCCCCCCCCCHHHH		16.64-
29N-linked_GlycosylationGARATPYSLQVTLTL
CCCCCCCHHHHHHHH		17.33-
132PhosphorylationCAISLDRYWSITQAI
HHHHHHHCHHHHHHH		11.8146159919
134PhosphorylationISLDRYWSITQAIEY
HHHHHCHHHHHHHHH		13.5646159901
136PhosphorylationLDRYWSITQAIEYNL
HHHCHHHHHHHHHHH		13.3646159913
171PhosphorylationISFPPLISIEKKGGG
HHCCCCEEEEECCCC		32.1746159907
175AcetylationPLISIEKKGGGGGPQ
CCEEEEECCCCCCCC		50.427427267
232PhosphorylationRRTRVPPSRRGPDAV
HCCCCCCHHCCCCCC		28.6522817900
246PhosphorylationVAAPPGGTERRPNGL
CCCCCCCCCCCCCCC		32.0354886087
247PhosphorylationAAPPGGTERRPNGLG
CCCCCCCCCCCCCCC		50.3911732925
258PhosphorylationNGLGPERSAGPGGAE
CCCCCCCCCCCCCCC		35.60101545321
261PhosphorylationGPERSAGPGGAEAEP
CCCCCCCCCCCCCCC		37.45-
273PhosphorylationAEPLPTQLNGAPGEP
CCCCCCCCCCCCCCC		7.6024719451
288PhosphorylationAPAGPRDTDALDLEE
CCCCCCCCCCCCCCC		25.1729449344
296PhosphorylationDALDLEESSSSDHAE
CCCCCCCCCCCCCCC		26.5823401153
297PhosphorylationALDLEESSSSDHAER
CCCCCCCCCCCCCCC		36.8222167270
298PhosphorylationLDLEESSSSDHAERP
CCCCCCCCCCCCCCC		49.4122167270
299PhosphorylationDLEESSSSDHAERPP
CCCCCCCCCCCCCCC		35.0522167270
311PhosphorylationRPPGPRRPERGPRGK
CCCCCCCCCCCCCCC		36.607876239
312PhosphorylationPPGPRRPERGPRGKG
CCCCCCCCCCCCCCC		69.347876239
313PhosphorylationPGPRRPERGPRGKGK
CCCCCCCCCCCCCCC		64.207876239
314PhosphorylationGPRRPERGPRGKGKA
CCCCCCCCCCCCCCC		18.0019651622
324PhosphorylationGKGKARASQVKPGDS
CCCCCCCCCCCCCCC		29.9221955146
331PhosphorylationSQVKPGDSLPRRGPG
CCCCCCCCCCCCCCC		46.3023401153
339PhosphorylationLPRRGPGATGIGTPA
CCCCCCCCCCCCCCC		13.0424719451
344PhosphorylationPGATGIGTPAAGPGE
CCCCCCCCCCCCCCH		14.0829214152
346PhosphorylationATGIGTPAAGPGEER
CCCCCCCCCCCCHHH		25.5324719451
353MethylationAAGPGEERVGAAKAS
CCCCCHHHHCHHHHH		28.06-
359PhosphorylationERVGAAKASRWRGRQ
HHHCHHHHHHHCCCC		10.29-
360PhosphorylationRVGAAKASRWRGRQN
HHCHHHHHHHCCCCC		31.5011864637
368MethylationRWRGRQNREKRFTFV
HHCCCCCHHHHHHHH		42.34-
375PhosphorylationREKRFTFVLAVVIGV
HHHHHHHHHHHHHHH		2.81-
457S-palmitoylationV--------------
C--------------		-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
232SPhosphorylationKinasePKC-FAMILY-GPS
232SPhosphorylationKinasePKC_GROUP-PhosphoELM
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADA2A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADA2A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UCHL1_HUMANUCHL1physical
19477270
GNAI2_HUMANGNAI2physical
15782186
GBB1_HUMANGNB1physical
15782186
GBG2_HUMANGNG2physical
15782186
ADA2A_HUMANADRA2Aphysical
16352729
GNAO_HUMANGNAO1physical
16352729
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00076 Noradrenaline (JP16); Norepinephrine (INN); Nor adrenalin (TN)
D00095 Adrenaline (JP16); Epinephrine (USP/INN); Adrenalin (TN); Auvi-q (TN); Epipen (TN)
D00124 Ephedrine (USP); Ephedrine (TN)
D00270 Chlorpromazine (USP/INN); Thorazine (TN)
D00281 Clonidine (JAN/USP/INN); Catarpres-TTS (TN)
D00403 Levomepromazine (USAN/INN); Methotrimeprazine (USP); Levoprome (TN)
D00405 Methyldopa hydrate (JP16); Methyldopa (USP); Aldomet (TN)
D00485 Pseudoephedrine hydrochloride (USP); Sudafed (TN)
D00507 Phenoxybenzamine hydrochloride (USP); Dibenzyline (TN)
D00509 Phentolamine mesilate (JAN/INN); Phentolamine mesylate (USP); Regitine (TN)
D00514 Dexmedetomidine (USAN/INN); Dexdor (TN); Precedex (TN)
D00563 Mirtazapine (JAN/USAN/INN); Remeron (TN); Reflex (TN)
D00604 Clonidine hydrochloride (JP16/USP); Catapres (TN)
D00605 Guanabenz acetate (JP16/USP); Wytensin (TN)
D00606 Guanfacine hydrochloride (JAN/USP); Tenex (TN)
D00607 Guanadrel sulfate (USP); Hylorel (TN)
D00680 Methylergometrine maleate (JP16); Methylergonovine maleate (USP); Methergine (TN)
D00776 Tizanidine hydrochloride (JP16/USAN); Zanaflex (TN)
D00789 Chlorpromazine hydrochloride (JP16/USP); Sonazine (TN)
D00996 Epinephrine hydrochloride (JAN); Adrenalin chloride (TN)
D00997 Tolazoline hydrochloride (JAN/USP); Priscoline (TN)
D01008 Apraclonidine hydrochloride (JAN/USP); Iopidine (TN)
D01017 Dipivefrin hydrochloride (JAN/USP); Propine (TN)
D01019 Metaraminol bitartrate (JAN/USP); Aramine (TN)
D01163 Ergometrine maleate (JP16); Ergonovine maleate (USP); Ergometrine (TN)
D01205 Dexmedetomidine hydrochloride (JAN/USAN); Precedex (TN)
D01358 Mianserin hydrochloride (JAN/USAN); Tetramide (TN)
D01386 Ephedrine hydrochloride (JP16/USP); Ephedrine hydrochloride (TN)
D01520 Levomepromazine hydrochloride (JAN/USAN); Nozinan (TN)
D01952 L-Methylephedrine hydrochloride (JAN)
D02034 Setiptiline maleate (JAN); Tecipul (TN)
D02076 Brimonidine tartrate (JAN/USAN); Alphagan (TN)
D02109 dl-Methylephedrine hydrochloride (JP16); Methy-F (TN)
D02149 Epinephrine bitartrate (JAN/USP); Asmatane mist (TN); Medihaler-epi (TN)
D02248 Levomepromazine maleate (JP16/USAN); Hirnamin (TN)
D02349 Dipivefrin (USAN); Dipivefrine (INN)
D02388 Levonordefrin (USP); Corbadrine (INN); Neo-cobefrin (TN)
D02972 Aptazapine maleate (USAN)
D02995 Asenapine maleate (USAN); Saphris (TN)
D03002 Atipamezole (USAN/INN); Antisedan (TN)
D03274 Chlorpromazine hibenzate (JAN); Contomin (TN)
D03648 Dapiprazole hydrochloride (USAN); Rev-Eyes (TN)
D03672 Delequamine hydrochloride (USAN)
D03702 Detomidine hydrochloride (USAN)
D04018 Ephedrine sulfate (USP); Isofedrol (TN)
D04034 Chlorpromazine phenolphthalinate (JAN); Wintermin (TN)
D04124 Fadolmidine hydrochloride (USAN)
D04223 Fluparoxan hydrochloride (USAN)
D04375 Guanabenz (USAN/INN)
D04883 Medetomidine hydrochloride (USAN)
D05206 Norepinephrine bitartrate (USP); Levophed (TN)
D05648 Pseudoephedrine polistirex (USAN); Pseudo-12 (TN)
D05649 Pseudoephedrine sulfate (USP); Afrinol (TN)
D06344 Xylazine hydrochloride (USP); Rompun (TN)
D06671 Yohimbine hydrochloride (USP)
D07148 Oxedrine (BAN); (+/-)-Synephrine
D07305 Piribedil (INN); Trivastal (TN)
D07461 Apraclonidine (INN); Iopidine (TN)
D07540 Brimonidine (INN)
D07795 Detomidine (INN)
D07905 Ergometrine (INN)
D08031 Guanfacine (INN); Estulic (TN)
D08165 Medetomidine (INN); Domitor [veterinary]
D08192 Metaraminol (INN)
D08205 Methyldopa (INN); Aldomet (TN)
D08206 Methylephedrine (BAN)
D08207 Methylergometrine (INN); Ergotyl (TN)
D08216 Mianserin (INN); Tolvon (TN)
D08284 Norepinephrine hydrochoride; (-)-Noradrenaline hydrochloride; Arterenol (TN)
D08308 Oxedrine tartrate; Dacryoboraline (TN)
D08309 Oxedrine hydrochloride; Ocuton (TN)
D08358 Phenoxybenzamine (INN)
D08362 Phentolamine (INN)
D08449 Pseudoephedrine (INN); Neodurasina (TN); Acunaso (TN)
D08482 Rilmenidine (INN); Hyperium (TN)
D08487 Romifidine (INN); Sedivet (TN)
D08511 Setiptiline (INN)
D08611 Tizanidine (INN); Sirdalud (TN)
D08614 Tolazoline (INN); Tolazine [veterinary] (TN)
D08683 Xylazine (USP/INN); Chanazine (TN)
D08685 Yohimbine (DCF)
D09794 Norepinephrine hydrochloride (JAN); (+/-)-Noradrenaline hydrochloride
D09819 Chlorpromazine tannate (JAN)
D09842 dl-Methylephedrine saccharinate (JAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADA2A_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297; SER-298 ANDSER-299, AND MASS SPECTROMETRY.

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