ZN428_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN428_HUMAN
• UniProt AC: Q96B54
• Protein Name: Zinc finger protein 428
• Gene Name: ZNF428
• Organism: Homo sapiens (Human).
• Sequence Length: 188
• Protein Sequence: MTETREPAETGGYASLEEDDEDLSPGPEHSSDSEYTLSEPDSEEEEDEEEEEEETTDDPEYDPGYKVKQRLGGGRGGPSRRAPRAAQPPAQPCQLCGRSPLGEAPPGTPPCRLCCPATAPQEAPAPEGRALGEEEEEPPRAGEGRPAGREEEEEEEEEGTYHCTECEDSFDNLGELHGHFMLHARGEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Methylation	KQRLGGGRGGPSRRA CCCCCCCCCCCCCCC	50.61	16187591
99	Phosphorylation	PCQLCGRSPLGEAPP CCCCCCCCCCCCCCC	15.12	29255136
108	Phosphorylation	LGEAPPGTPPCRLCC CCCCCCCCCCCCEEC	29.81	29255136
118	Phosphorylation	CRLCCPATAPQEAPA CCEECCCCCCCCCCC	24.82	26552605
160	Phosphorylation	EEEEEEGTYHCTECE HHHHHHCCEEECCCC	17.24	22210691
161	Phosphorylation	EEEEEGTYHCTECED HHHHHCCEEECCCCC	13.02	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN428_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN428_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN428_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHAP1_HUMAN	CHAMP1	physical	28514442
POGZ_HUMAN	POGZ	physical	28514442
FOXK2_HUMAN	FOXK2	physical	28514442
FOXK1_HUMAN	FOXK1	physical	28514442
PI42C_HUMAN	PIP4K2C	physical	28514442
PARP2_HUMAN	PARP2	physical	28514442
PI42B_HUMAN	PIP4K2B	physical	28514442
H2AY_HUMAN	H2AFY	physical	28514442
GTF2I_HUMAN	GTF2I	physical	28514442
XPC_HUMAN	XPC	physical	28514442
H2A2B_HUMAN	HIST2H2AB	physical	28514442
PI42A_HUMAN	PIP4K2A	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99 AND THR-108, AND MASSSPECTROMETRY.
PubMed: 18669648

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-108, AND MASSSPECTROMETRY.
PubMed: 19413330

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-108, AND MASSSPECTROMETRY.
PubMed: 18220336