WLS_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WLS_DROME
• UniProt AC: Q95ST2
• Protein Name: Protein wntless {ECO:0000303|PubMed:16678095, ECO:0000303|PubMed:18160348, ECO:0000303|PubMed:18193032, ECO:0000303|PubMed:18193037}
• Gene Name: wls {ECO:0000303|PubMed:16678095, ECO:0000303|PubMed:18160348, ECO:0000303|PubMed:18193032, ECO:0000303|PubMed:18193037}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 594
• Subcellular Localization: Cell junction, synapse, presynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane prot
• Protein Description: A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles. Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip..
• Protein Sequence: MSGTILENLSGRKLSILVATLLLCQVLCFLLGGLYAPLPAGHVTVLGSLCREDHARQNDTSFLLYSRGAGACIPVTREEVEQDSTKMANELVHVFQMPLPRDLRDLDYSRWQQNLIGVLQVEFGYDSSSELREPPRELQLTIDMRLAYRNKGDPDNGWKLYAHGVEHRYLDCVTSHVGPTETLYSCDMIPLFELGALHHSFYLLNLRFPLDTPSQMNLQFGHMHDLTLTAIHQNGGFTQIWLLLKTMLFPFVVGIMIWFWRRVHLLQRSPALLEYMLIYLGAALTFLNLPLEYLSLVYEMPYMLLLSDIRQGIFYAMLLTFWLVFAGEHMLIQDAPNKSTIRSRYWKHLSAVVVGCISLFVFDICERGVQLRNPFYSIWTTPLGAKVAMTFIVLAGVSAAIYFLFLCYMIWKVFRNIGDKRTSLPSMSQARRLHYEVPLDQKVEDWAGIVYFYTKAFFFQLHKANESKGLIYRFKFLMLATLVCAALTVAGFIMGQMAEGQWDWNDNVAIQPTSAFLTGVYGMWNIYIFALLILYAPSHKQWPTMHHSDETTQSNENIVASAASEEIEFSHLPSDSNPSEISSLTSFTRKVAFD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	N-linked_Glycosylation	REDHARQNDTSFLLY CHHHHHCCCCEEEEE	49.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WLS_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WLS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WLS_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WNT5_DROME	Wnt5	physical	22108505
WNT4_DROME	Wnt4	physical	22108505
WNTG_DROME	wg	physical	22108505
WNT2_DROME	Wnt2	physical	22108505

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.