WDR53_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR53_HUMAN
• UniProt AC: Q7Z5U6
• Protein Name: WD repeat-containing protein 53
• Gene Name: WDR53
• Organism: Homo sapiens (Human).
• Sequence Length: 358
• Protein Sequence: MAVKWTGGHSSPVLCLNASKEGLLASGAEGGDLTAWGEDGTPLGHTRFQGADDVTSVLFSPSCPTKLYASHGETISVLDVRSLKDSLDHFHVNEEEINCLSLNQTENLLASADDSGAIKILDLENKKVIRSLKRHSNICSSVAFRPQRPQSLVSCGLDMQVMLWSLQKARPLWITNLQEDETEEMEGPQSPGQLLNPALAHSISVASCGNIFSCGAEDGKVRIFRVMGVKCEQELGFKGHTSGVSQVCFLPESYLLLTGGNDGKITLWDANSEVEKKQKSPTKRTHRKKPKRGTCTKQGGNTNASVTDEEEHGNILPKLNIEHGEKVNWLLGTKIKGHQNILVADQTSCISVYPLNEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	VKWTGGHSSPVLCLN CEECCCCCCCEEEEE	39.34	25627689
11	Phosphorylation	KWTGGHSSPVLCLNA EECCCCCCCEEEEEC	17.22	25159151
20	Ubiquitination	VLCLNASKEGLLASG EEEEECCCCCEECCC	54.08	-
60	Phosphorylation	DVTSVLFSPSCPTKL CCCEEEECCCCCCEE	16.25	25159151
86	Phosphorylation	DVRSLKDSLDHFHVN EHHHHHHHCCCCCCC	33.82	-
111	Phosphorylation	QTENLLASADDSGAI CHHHHHHCCCCCCCE	32.00	-
126	Ubiquitination	KILDLENKKVIRSLK EEEECCCHHHHHHHH	38.76	-
127	Ubiquitination	ILDLENKKVIRSLKR EEECCCHHHHHHHHH	55.25	-
276	Ubiquitination	DANSEVEKKQKSPTK ECCHHHHHHHCCCCC	66.72	-
277	Ubiquitination	ANSEVEKKQKSPTKR CCHHHHHHHCCCCCC	49.83	-
302	Phosphorylation	CTKQGGNTNASVTDE CCCCCCCCCCCCCCH	35.12	20873877
305	Phosphorylation	QGGNTNASVTDEEEH CCCCCCCCCCCHHHH	27.85	20873877
307	Phosphorylation	GNTNASVTDEEEHGN CCCCCCCCCHHHHCC	34.89	25627689
326	Ubiquitination	LNIEHGEKVNWLLGT CCCCCCCEEEEEEEC	45.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR53_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR53_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR53_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDR5_HUMAN	WDR5	physical	17041588
BBS1_HUMAN	BBS1	physical	26186194
RSAD1_HUMAN	RSAD1	physical	26186194
EF1A2_HUMAN	EEF1A2	physical	26186194
RSAD1_HUMAN	RSAD1	physical	28514442
EF1A2_HUMAN	EEF1A2	physical	28514442
NACAD_HUMAN	NACAD	physical	28514442
BIEA_HUMAN	BLVRA	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.