UNKL_HUMAN - dbPTM
UNKL_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UNKL_HUMAN
UniProt AC Q9H9P5
Protein Name Putative E3 ubiquitin-protein ligase UNKL
Gene Name UNKL
Organism Homo sapiens (Human).
Sequence Length 680
Subcellular Localization Isoform 4: Cytoplasm. Nucleus. Isoform 4 is primarily localized in the cytoplasm but has the ability to shuttle between the nucleus and the cytoplasm.
Protein Description May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven..
Protein Sequence MPSVSKAAAAALSGSPPQTEKPTHYRYLKEFRTEQCPLFSQHKCAQHRPFTCFHWHFLNQRRRRPLRRRDGTFNYSPDVYCSKYNEATGVCPDGDECPYLHRTTGDTERKYHLRYYKTGTCIHETDARGHCVKNGLHCAFAHGPLDLRPPVCDVRELQAQEALQNGQLGGGEGVPDLQPGVLASQAMIEKILSEDPRWQDANFVLGSYKTEQCPKPPRLCRQGYACPHYHNSRDRRRNPRRFQYRSTPCPSVKHGDEWGEPSRCDGGDGCQYCHSRTEQQFHPESTKCNDMRQTGYCPRGPFCAFAHVEKSLGMVNEWGCHDLHLTSPSSTGSGQPGNAKRRDSPAEGGPRGSEQDSKQNHLAVFAAVHPPAPSVSSSVASSLASSAGSGSSSPTALPAPPARALPLGPASSTVEAVLGSALDLHLSNVNIASLEKDLEEQDGHDLGAAGPRSLAGSAPVAIPGSLPRAPSLHSPSSASTSPLGSLSQPLPGPVGSSAMTPPQQPPPLRSEPGTLGSAASSYSPLGLNGVPGSIWDFVSGSFSPSPSPILSAGPPSSSSASPNGAELARVRRQLDEAKRKIRQWEESWQQVKQVCDAWQREAQEAKERARVADSDRQLALQKKEEVEAQVIFQLRAKQCVACRERAHGAVLRPCQHHILCEPCAATAPECPYCKGQPLQW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2 (in isoform 2)Phosphorylation-43.3625159151
2 (in isoform 1)Phosphorylation-43.3625159151
3Phosphorylation-----MPSVSKAAAA
-----CCCHHHHHHH		37.4126091039
13PhosphorylationKAAAAALSGSPPQTE
HHHHHHHHCCCCCCC		32.2821955146
15PhosphorylationAAAALSGSPPQTEKP
HHHHHHCCCCCCCCC		29.9930266825
19PhosphorylationLSGSPPQTEKPTHYR
HHCCCCCCCCCCHHH		52.3121955146
23PhosphorylationPPQTEKPTHYRYLKE
CCCCCCCCHHHHHHH		42.4823663014
25PhosphorylationQTEKPTHYRYLKEFR
CCCCCCHHHHHHHHC		11.9323663014
76PhosphorylationRDGTFNYSPDVYCSK
CCCCCCCCCCEEECC		18.7430576142
82PhosphorylationYSPDVYCSKYNEATG
CCCCEEECCCCCCCC		22.0830576142
326PhosphorylationGCHDLHLTSPSSTGS
CCCEEEECCCCCCCC		28.0425627689
327PhosphorylationCHDLHLTSPSSTGSG
CCEEEECCCCCCCCC		29.1925627689
344PhosphorylationGNAKRRDSPAEGGPR
CCCCCCCCCCCCCCC		24.9725850435
347PhosphorylationKRRDSPAEGGPRGSE
CCCCCCCCCCCCCCC		68.9827251275
427PhosphorylationSALDLHLSNVNIASL
HHHHHHHHCCCHHHH		28.1627251275
430PhosphorylationDLHLSNVNIASLEKD
HHHHHCCCHHHHHHH		28.4927251275
453PhosphorylationLGAAGPRSLAGSAPV
CCCCCCHHHCCCCCE		26.2128348404
456PhosphorylationAGPRSLAGSAPVAIP
CCCHHHCCCCCEECC		29.6327251275
465PhosphorylationAPVAIPGSLPRAPSL
CCEECCCCCCCCCCC		29.8228348404
468PhosphorylationAIPGSLPRAPSLHSP
ECCCCCCCCCCCCCC		65.5127251275
471PhosphorylationGSLPRAPSLHSPSSA
CCCCCCCCCCCCCCC		37.4229449344
474PhosphorylationPRAPSLHSPSSASTS
CCCCCCCCCCCCCCC		31.6029449344
476PhosphorylationAPSLHSPSSASTSPL
CCCCCCCCCCCCCCC		41.3629449344
477PhosphorylationPSLHSPSSASTSPLG
CCCCCCCCCCCCCCC		29.6229449344
479PhosphorylationLHSPSSASTSPLGSL
CCCCCCCCCCCCCCC		31.2229449344
480PhosphorylationHSPSSASTSPLGSLS
CCCCCCCCCCCCCCC		33.8026091039
481PhosphorylationSPSSASTSPLGSLSQ
CCCCCCCCCCCCCCC		18.6826091039
485PhosphorylationASTSPLGSLSQPLPG
CCCCCCCCCCCCCCC		32.3126091039
487PhosphorylationTSPLGSLSQPLPGPV
CCCCCCCCCCCCCCC		31.3029449344
496PhosphorylationPLPGPVGSSAMTPPQ
CCCCCCCCCCCCCCC		18.3726091039
500PhosphorylationPVGSSAMTPPQQPPP
CCCCCCCCCCCCCCC		31.3727732954
737 (in isoform 6)Phosphorylation--
751 (in isoform 6)Phosphorylation--
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UNKL_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UNKL_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UNKL_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAC1_HUMANRAC1physical
20148946
SMRD2_HUMANSMARCD2physical
20148946
KDM1A_HUMANKDM1Aphysical
23455924
PPCEL_HUMANPREPLphysical
26186194
SAHH3_HUMANAHCYL2physical
26186194
GGPPS_HUMANGGPS1physical
28514442
TP4AP_HUMANTRPC4APphysical
28514442
SAHH3_HUMANAHCYL2physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UNKL_HUMAN

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Related Literatures of Post-Translational Modification

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