ULK4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ULK4_HUMAN
• UniProt AC: Q96C45
• Protein Name: Serine/threonine-protein kinase ULK4
• Gene Name: ULK4
• Organism: Homo sapiens (Human).
• Sequence Length: 1275
• Protein Description: May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility..
• Protein Sequence: MENFILYEEIGRGSKTVVYKGRRKGTINFVAILCTDKCKRPEITNWVRLTREIKHKNIVTFHEWYETSNHLWLVVELCTGGSLKTVIAQDENLPEDVVREFGIDLISGLHHLHKLGILFCDISPRKILLEGPGTLKFSNFCLAKVEGENLEEFFALVAAEEGGGDNGENVLKKSMKSRVKGSPVYTAPEVVRGADFSISSDLWSLGCLLYEMFSGKPPFFSESISELTEKILCEDPLPPIPKDSSRPKASSDFINLLDGLLQRDPQKRLTWTRLLQHSFWKKAFAGADQESSVEDLSLSRNTMECSGPQDSKELLQNSQSRQAKGHKSGQPLGHSFRLENPTEFRPKSTLEGQLNESMFLLSSRPTPRTSTAVEVSPGEDMTHCSPQKTSPLTKITSGHLSQQDLESQMRELIYTDSDLVVTPIIDNPKIMKQPPVKFDAKILHLPTYSVDKLLFLKDQDWNDFLQQVCSQIDSTEKSMGASRAKLNLLCYLCVVAGHQEVATRLLHSPLFQLLIQHLRIAPNWDIRAKVAHVIGLLASHTAELQENTPVVEAIVLLTELIRENFRNSKLKQCLLPTLGELIYLVATQEEKKKNPRECWAVPLAAYTVLMRCLREGEERVVNHMAAKIIENVCTTFSAQSQGFITGEIGPILWYLFRHSTADSLRITAVSALCRITRHSPTAFQNVIEKVGLNSVINSLASAICKVQQYMLTLFAAMLSCGIHLQRLIQEKGFVSTIIRLLDSPSTCIRAKAFLVLLYILIYNREMLLLSCQARLVMYIERDSRKTTPGKEQQSGNEYLSKCLDLLICHIVQELPRILGDILNSLANVSGRKHPSTVQVKQLKLCLPLMPVVLHLVTSQVFRPQVVTEEFLFSYGTILSHIKSVDSGETNIDGAIGLTASEEFIKITLSAFEAIIQYPILLKDYRSTVVDYILPPLVSLVQSQNVEWRLFSLRLLSETTSLLVNQEFGDGKEKASVDSDSNLLALIRDVLLPQYEHILLEPDPVPAYALKLLVAMTEHNPTFTRLVEESKLIPLIFEVTLEHQESILGNTMQSVIALLSNLVACKDSNMELLYEQGLVSHICNLLTETATLCLDVDNKNNNEMAAPLLFSLLDILHSMLTYTSGIVRLALQAQKSGSGEDPQAAEDLLLLNRPLTDLISLLIPLLPNEDPEIFDVSSKCLSILVQLYGGENPDSLSPENVEIFAHLLTSKEDPKEQKLLLRILRRMITSNEKHLESLKNAGSLLRALERLAPGSGSFADSAVAPLALEILQAVGH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
177	Phosphorylation	VLKKSMKSRVKGSPV HHHHHHHHHCCCCCC	33.39	-
297	Phosphorylation	ESSVEDLSLSRNTME CCCHHHHHCCCCCCC	36.30	24719451
299	Phosphorylation	SVEDLSLSRNTMECS CHHHHHCCCCCCCCC	21.80	17081983
335	Phosphorylation	SGQPLGHSFRLENPT CCCCCCCCEECCCCC	15.40	28555341
362	Phosphorylation	NESMFLLSSRPTPRT CCCHHHHCCCCCCCC	26.84	24719451
363	Phosphorylation	ESMFLLSSRPTPRTS CCHHHHCCCCCCCCC	42.10	24719451
382	Phosphorylation	VSPGEDMTHCSPQKT ECCCCCCCCCCCCCC	31.86	21712546
385	Phosphorylation	GEDMTHCSPQKTSPL CCCCCCCCCCCCCCC	23.82	21712546
389	Phosphorylation	THCSPQKTSPLTKIT CCCCCCCCCCCCHHC	30.26	21712546
390	Phosphorylation	HCSPQKTSPLTKITS CCCCCCCCCCCHHCC	25.58	21712546
393	Phosphorylation	PQKTSPLTKITSGHL CCCCCCCCHHCCCCC	24.64	21712546
447	Phosphorylation	AKILHLPTYSVDKLL CEEECCCCCCCCEEH	34.49	30206219
448	Phosphorylation	KILHLPTYSVDKLLF EEECCCCCCCCEEHH	12.54	22817900
449	Phosphorylation	ILHLPTYSVDKLLFL EECCCCCCCCEEHHC	26.73	30206219
577	Phosphorylation	LKQCLLPTLGELIYL HHHHHHHHHHHHHHH	47.57	-
583	Phosphorylation	PTLGELIYLVATQEE HHHHHHHHHHHCHHH	14.03	-
587	Phosphorylation	ELIYLVATQEEKKKN HHHHHHHCHHHHHCC	29.09	-
645	Phosphorylation	AQSQGFITGEIGPIL HHCCCEECCCHHHHH	26.88	-
709	Phosphorylation	AICKVQQYMLTLFAA HHHHHHHHHHHHHHH	4.13	24043423
712	Phosphorylation	KVQQYMLTLFAAMLS HHHHHHHHHHHHHHH	11.87	24043423
719	Phosphorylation	TLFAAMLSCGIHLQR HHHHHHHHCCHHHHH	9.38	24043423
835	Phosphorylation	VSGRKHPSTVQVKQL CCCCCCCCCCCHHHH	40.71	22210691
836	Phosphorylation	SGRKHPSTVQVKQLK CCCCCCCCCCHHHHH	21.29	22210691
1228	Phosphorylation	RILRRMITSNEKHLE HHHHHHHHCCHHHHH	19.02	-
1229	Phosphorylation	ILRRMITSNEKHLES HHHHHHHCCHHHHHH	31.87	18669648
1254	Phosphorylation	LERLAPGSGSFADSA HHHHCCCCCCCCHHH	30.15	28348404
1256	Phosphorylation	RLAPGSGSFADSAVA HHCCCCCCCCHHHHH	20.96	28348404
1260	Phosphorylation	GSGSFADSAVAPLAL CCCCCCHHHHHHHHH	22.63	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ULK4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ULK4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
577	Phosphorylation	569 (8)	K ⇒ R	rs3774372	Blood pressure	21909110

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
1433T_HUMAN	YWHAQ	physical	21988832
ANR40_HUMAN	ANKRD40	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.