UB2E3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UB2E3_MOUSE
• UniProt AC: P52483
• Protein Name: Ubiquitin-conjugating enzyme E2 E3
• Gene Name: Ube2e3
• Organism: Mus musculus (Mouse).
• Sequence Length: 207
• Subcellular Localization: Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.
• Protein Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination (By similarity). Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest..
• Protein Sequence: MSSDRQRSDDESPSTSSGSSDADQRDPAAPEPEEQEERKPSATQQKKNTKLSSKTTAKLSTSAKRIQKELAEITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFSSDYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLTNRAEHDRIARQWTKRYAT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSDRQRSD ------CCCCCCCCC	40.73	-
2	Phosphorylation	------MSSDRQRSD ------CCCCCCCCC	40.73	23375375
8	Phosphorylation	MSSDRQRSDDESPST CCCCCCCCCCCCCCC	40.87	25521595
12	Phosphorylation	RQRSDDESPSTSSGS CCCCCCCCCCCCCCC	31.01	25159016
14	Phosphorylation	RSDDESPSTSSGSSD CCCCCCCCCCCCCCC	50.64	25159016
15	Phosphorylation	SDDESPSTSSGSSDA CCCCCCCCCCCCCCH	30.23	25159016
16	Phosphorylation	DDESPSTSSGSSDAD CCCCCCCCCCCCCHH	36.72	25159016
17	Phosphorylation	DESPSTSSGSSDADQ CCCCCCCCCCCCHHH	42.66	25159016
19	Phosphorylation	SPSTSSGSSDADQRD CCCCCCCCCCHHHCC	27.30	25159016
20	Phosphorylation	PSTSSGSSDADQRDP CCCCCCCCCHHHCCC	40.10	25159016
58	Acetylation	LSSKTTAKLSTSAKR CCHHHHHHHHHHHHH	40.66	23806337
60	Phosphorylation	SKTTAKLSTSAKRIQ HHHHHHHHHHHHHHH	21.43	29514104
91	Phosphorylation	GPKGDNIYEWRSTIL CCCCCCEEEECCCEE	18.72	22817900
145	S-palmitoylation	INSQGVICLDILKDN CCCCCEEEEHHHCCC	2.31	28680068
150	Ubiquitination	VICLDILKDNWSPAL EEEEHHHCCCCCCCH	49.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UB2E3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UB2E3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UB2E3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RCBT1_MOUSE	Rcbtb1	physical	19256485
RNF5_MOUSE	Rnf5	physical	19256485
ARI2_MOUSE	Arih2	physical	19256485
RCBT1_HUMAN	RCBTB1	physical	19256485
RNF25_HUMAN	RNF25	physical	19256485

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-91, AND MASSSPECTROMETRY.
PubMed: 17947660