RNF5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RNF5_MOUSE
• UniProt AC: O35445
• Protein Name: E3 ubiquitin-protein ligase RNF5
• Gene Name: Rnf5
• Organism: Mus musculus (Mouse).
• Sequence Length: 180
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Mitochondrion membrane. Endoplasmic reticulum membrane. Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.
• Protein Description: Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150 'leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses..
• Protein Sequence: MAAAEEEDGGPEGPNRERGGASATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPDRQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPESRGGFQPFGDAGGFHFSFGVGAFPFGFFTTVFNAHEPFRRGAGVDLGQGHPASSWQDSLFLFLAIFFFFWLLSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAEEEDG ------CCCCCCCCC	18.51	-
68	Ubiquitination	RQECPVCKAGISREK HHCCCCCCCCCCHHH	50.29	22790023
75	Ubiquitination	KAGISREKVVPLYGR CCCCCHHHEECCCCC	47.63	22790023
84	Phosphorylation	VPLYGRGSQKPQDPR ECCCCCCCCCCCCCC	33.40	-
93	Ubiquitination	KPQDPRLKTPPRPQG CCCCCCCCCCCCCCC	61.33	27667366
94	Phosphorylation	PQDPRLKTPPRPQGQ CCCCCCCCCCCCCCC	43.02	25159016
107	Phosphorylation	GQRPAPESRGGFQPF CCCCCCCCCCCCCCC	34.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RNF5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RNF5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RNF5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RNF5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.