| UniProt ID | TTLL3_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y4R7 | |
| Protein Name | Tubulin monoglycylase TTLL3 | |
| Gene Name | TTLL3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 772 | |
| Subcellular Localization | Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. | |
| Protein Description | Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.. | |
| Protein Sequence | MNRLRNAKIYVERAVKQKKIFTIQGCYPVIRCLLRRRGWVEKKMVHRSGPTLLPPQKDLDSSAMGDSDTTEDEDEDEDEEFQPSQLFDFDDLLKFDDLDGTHALMVGLCLNLRNLPWFDEVDANSFFPRCYCLGAEDDKKAFIEDFWLTAARNVLKLVVKSEWKSYPIQAVEEEASGDKQPKKQEKNPVLVSPEFVDEALCACEEYLSNLAHMDIDKDLEAPLYLTPEGWSLFLQRYYQVVHEGAELRHLDTQVQRCEDILQQLQAVVPQIDMEGDRNIWIVKPGAKSRGRGIMCMDHLEEMLKLVNGNPVVMKDGKWVVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSIQKHLENSCHRHPLLPPDNMWSSQRFQAHLQEMGAPNAWSTIIVPGMKDAVIHALQTSQDTVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRMLDRNCDTGAFELIYKQPAVEVPQYVGIRLLVEGFTIKKPMAMCHRRMGVRPAVPLLTQRGSGEARHHFPSLHTKAQLPSPHVLRHQGQVLRRQHSKLVGTKALSTTGKALRTLPTAKVFISLPPNLDFKVAPSILKPRKAPALLCLRGPQLEVPCCLCPLKSEQFLAPVGRSRPKANSRPDCDKPRAEACPMKRLSPLKPLPLVGTFQRRRGLGDMKLGKPLLRFPTALVLDPTPNKKKQVKYLGLDSIAVGGSRVDGARPCTPGSTARA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | RLRNAKIYVERAVKQ HHHHCEEEHHHHHHH | 8.78 | - | |
| 11 | Phosphorylation | LRNAKIYVERAVKQK HHHCEEEHHHHHHHC | 4.58 | - | |
| 55 | Phosphorylation | SGPTLLPPQKDLDSS CCCCCCCCCCCCCCC | 54.55 | - | |
| 102 (in isoform 2) | Ubiquitination | - | 23.53 | - | |
| 138 | Phosphorylation | YCLGAEDDKKAFIED EEECCCCCHHHHHHH | 45.95 | - | |
| 139 | Phosphorylation | CLGAEDDKKAFIEDF EECCCCCHHHHHHHH | 59.32 | - | |
| 142 | Phosphorylation | AEDDKKAFIEDFWLT CCCCHHHHHHHHHHH | 9.61 | 24719451 | |
| 153 | Phosphorylation | FWLTAARNVLKLVVK HHHHHHHHHHHHHHH | 38.45 | 24719451 | |
| 304 | Acetylation | DHLEEMLKLVNGNPV HHHHHHHHHHCCCEE | 49.42 | 68812621 | |
| 314 | Acetylation | NGNPVVMKDGKWVVQ CCCEEECCCCCEEHH | 52.28 | 68812615 | |
| 438 | Phosphorylation | AVIHALQTSQDTVQC HHHHHHHCCCCHHHH | 29.25 | - | |
| 453 | Phosphorylation | RKASFELYGADFVFG CHHHEEEECCCEEEC | 11.76 | 25311616 | |
| 473 | Phosphorylation | WLIEINASPTMAPST EEEEECCCCCCCCCH | 19.20 | 25311616 | |
| 475 | Phosphorylation | IEINASPTMAPSTAV EEECCCCCCCCCHHH | 24.38 | 25311616 | |
| 572 | Phosphorylation | EARHHFPSLHTKAQL CHHHCCCCCCCCCCC | 31.66 | 27251275 | |
| 581 | Phosphorylation | HTKAQLPSPHVLRHQ CCCCCCCCHHHHHHH | 35.91 | 21964256 | |
| 617 | Phosphorylation | KALRTLPTAKVFISL HHHHHCCCEEEEEEC | 42.07 | 24719451 | |
| 635 | Phosphorylation | LDFKVAPSILKPRKA CCCCCCCHHCCCCCC | 30.71 | 24719451 | |
| 677 | Ubiquitination | PVGRSRPKANSRPDC CCCCCCCCCCCCCCC | 60.12 | - | |
| 698 | Phosphorylation | ACPMKRLSPLKPLPL CCCCCCCCCCCCCCC | 32.02 | 24719451 | |
| 715 | Phosphorylation | TFQRRRGLGDMKLGK ECCCCCCCCCCCCCC | 5.08 | 27251275 | |
| 765 | O-linked_Glycosylation | VDGARPCTPGSTARA CCCCCCCCCCCCCCC | 33.11 | 30620550 | |
| 778 | Phosphorylation | RA------------- CC------------- | - | ||
| 841 | Phosphorylation | ---------------------------------------------------------------------------- ---------------------------------------------------------------------------- | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TTLL3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TTLL3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TTLL3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TCPH_HUMAN | CCT7 | physical | 26186194 | |
| HS71L_HUMAN | HSPA1L | physical | 26186194 | |
| TCPG_HUMAN | CCT3 | physical | 26186194 | |
| TCPW_HUMAN | CCT6B | physical | 26186194 | |
| TCPZ_HUMAN | CCT6A | physical | 26186194 | |
| TCPA_HUMAN | TCP1 | physical | 26186194 | |
| TCPD_HUMAN | CCT4 | physical | 26186194 | |
| TCPB_HUMAN | CCT2 | physical | 26186194 | |
| PHLP_HUMAN | PDCL | physical | 26186194 | |
| ZNHI2_HUMAN | ZNHIT2 | physical | 26186194 | |
| SUFU_HUMAN | SUFU | physical | 26186194 | |
| TCPB_HUMAN | CCT2 | physical | 28514442 | |
| TCPG_HUMAN | CCT3 | physical | 28514442 | |
| SUFU_HUMAN | SUFU | physical | 28514442 | |
| TCPH_HUMAN | CCT7 | physical | 28514442 | |
| TCPD_HUMAN | CCT4 | physical | 28514442 | |
| TCPA_HUMAN | TCP1 | physical | 28514442 | |
| TCPZ_HUMAN | CCT6A | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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