TRFR_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRFR_RAT
• UniProt AC: Q01717
• Protein Name: Thyrotropin-releasing hormone receptor
• Gene Name: Trhr
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 412
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system..
• Protein Sequence: MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSFDDTCLASEKNGPSSCTYGYSLTAKQEKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	N-linked_Glycosylation	-----MENETVSELN -----CCCCCHHHHH	49.27	-
10	N-linked_Glycosylation	NETVSELNQTELPPQ CCCHHHHHCCCCCHH	42.55	-
238	Phosphorylation	SKTWKNDSTHQNKNM CCCCCCCCCCCCCCC	36.86	25403869
355	Phosphorylation	YSVALNYSVIKESDR HHHEECHHHHCCCCC	19.12	17989235
360	Phosphorylation	NYSVIKESDRFSTEL CHHHHCCCCCCCCCC	29.14	17989235
364	Phosphorylation	IKESDRFSTELDDIT HCCCCCCCCCCCCEE	23.13	17989235
365	Phosphorylation	KESDRFSTELDDITV CCCCCCCCCCCCEEE	37.54	17989235
371	Phosphorylation	STELDDITVTDTYVS CCCCCCEEEEEEEEE	25.09	17989235
375	Phosphorylation	DDITVTDTYVSTTKV CCEEEEEEEEEEEEE	19.23	17989235
378	Phosphorylation	TVTDTYVSTTKVSFD EEEEEEEEEEEECCC	21.68	17989235
380	Phosphorylation	TDTYVSTTKVSFDDT EEEEEEEEEECCCCC	23.18	22817900
383	Phosphorylation	YVSTTKVSFDDTCLA EEEEEEECCCCCCCC	25.23	22817900
387	Phosphorylation	TKVSFDDTCLASEKN EEECCCCCCCCCCCC	15.97	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
355	S	Phosphorylation	Kinase	GRK2	P25098	PSP
360	S	Phosphorylation	Kinase	GRK2	P25098	PSP
364	S	Phosphorylation	Kinase	GRK2	P25098	PSP
365	T	Phosphorylation	Kinase	GRK2	P25098	PSP
365	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
371	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
383	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRFR_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRFR_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRFR_RAT	Trhr	physical	11278883
ARRB1_HUMAN	ARRB1	physical	12393857
ARRB2_HUMAN	ARRB2	physical	12393857
TRFR_RAT	Trhr	physical	12393857

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.