TOX4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TOX4_MOUSE
• UniProt AC: Q8BU11
• Protein Name: TOX high mobility group box family member 4
• Gene Name: Tox4
• Organism: Mus musculus (Mouse).
• Sequence Length: 619
• Subcellular Localization: Nucleus . Associated with chromatin.
• Protein Description: Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase..
• Protein Sequence: MEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGMTHGLMEQGGGLLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTNSLHEDGVDDFRRQLPAQKTVVVETGKKQKAPKKRKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYKDNQECQATVETVELDPVPQSQTPSPPPVTAADPASPAPASTESPALPPCIIVNSTLSSYVANQASSGPGGQPNITKLIITKQMLPSSITMSQGGMVTVIPATVVTSRGLQVGQTSTATIQPSQQAQIVTRSVLQAAAAAAASMQLPPPRLQPPPLQQMPQPPTQQQVTILQQPPPLQAMQQPPPQKVRINLQQQPPPLQSKIVPPPTLKIQTTVVPPTVESSPEQPMNSSPEAHTVEATSPETICEMIADVVPEVESPSQMDVELVSGSPVALSPQPRCVRSGCENPPVVSKDWDNEYCSNECVVKHCRDVFLAWVASRNPNSVVFVK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
174	Phosphorylation	QSPEDRLSTTPSPTN CCHHHHCCCCCCCCC	31.00	21082442
175	Phosphorylation	SPEDRLSTTPSPTNS CHHHHCCCCCCCCCC	47.52	26824392
176	Phosphorylation	PEDRLSTTPSPTNSL HHHHCCCCCCCCCCC	20.56	26824392
178	Phosphorylation	DRLSTTPSPTNSLHE HHCCCCCCCCCCCCC	42.11	27087446
180	Phosphorylation	LSTTPSPTNSLHEDG CCCCCCCCCCCCCCC	41.60	22942356
182	Phosphorylation	TTPSPTNSLHEDGVD CCCCCCCCCCCCCHH	33.31	27087446
207	Acetylation	TVVVETGKKQKAPKK EEEEECCCCCCCCCC	60.49	7611849
218	Acetylation	APKKRKKKDPNEPQK CCCCCCCCCCCCCCC	79.88	8277309
249	Phosphorylation	KGQNPNATFGEVSKI CCCCCCCCHHHHHHH	38.52	-
254	Phosphorylation	NATFGEVSKIVASMW CCCHHHHHHHHHHHH	16.62	-
313	Phosphorylation	DPVPQSQTPSPPPVT CCCCCCCCCCCCCCC	30.86	-
315	Phosphorylation	VPQSQTPSPPPVTAA CCCCCCCCCCCCCCC	54.12	-
479	Asymmetric dimethylarginine	QPPPQKVRINLQQQP CCCCCCEEEECCCCC	21.07	-
479	Methylation	QPPPQKVRINLQQQP CCCCCCEEEECCCCC	21.07	24129315
531	Phosphorylation	AHTVEATSPETICEM CEEEECCCHHHHHHH	27.99	-
548	Phosphorylation	DVVPEVESPSQMDVE HHCCCCCCCCCCCEE	34.72	-
550	Phosphorylation	VPEVESPSQMDVELV CCCCCCCCCCCEEEE	47.63	-
558	Phosphorylation	QMDVELVSGSPVALS CCCEEEECCCCCEEC	46.29	-
560	Phosphorylation	DVELVSGSPVALSPQ CEEEECCCCCEECCC	14.54	-
565	Phosphorylation	SGSPVALSPQPRCVR CCCCCEECCCCCCCC	16.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TOX4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TOX4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TOX4_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAD2_HUMAN	AK2	physical	26496610
PP1A_HUMAN	PPP1CA	physical	26496610
PP1B_HUMAN	PPP1CB	physical	26496610
PP1G_HUMAN	PPP1CC	physical	26496610
PP1RA_HUMAN	PPP1R10	physical	26496610
TAP2_HUMAN	TAP2	physical	26496610
MED14_HUMAN	MED14	physical	26496610
PALLD_HUMAN	PALLD	physical	26496610
PAF1_HUMAN	PAF1	physical	26496610
CDC73_HUMAN	CDC73	physical	26496610
WDR82_HUMAN	WDR82	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182, AND MASSSPECTROMETRY.
PubMed: 17242355