TOP2_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TOP2_CAEEL
• UniProt AC: Q23670
• Protein Name: DNA topoisomerase 2 top-2 {ECO:0000305}
• Gene Name: top-2 {ECO:0000303|PubMed:18202360, ECO:0000312|WormBase:K12D12.1}
• Organism: Caenorhabditis elegans.
• Sequence Length: 1520
• Subcellular Localization: Nucleus, nucleoplasm . Chromosome . Cytoplasm, cytoskeleton, spindle . In the hermaphrodite and male germline, localizes to the nucleoplasm in the proliferative mitotic zone except in metaphase where it localizes to the spindle. In the transition zon
• Protein Description: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (By similarity). Essential during mitosis in the adult germline and during embryogenesis for proper segregation of daughter chromosomes. [PubMed: 20116245]
• Protein Sequence: MSDSDSEFSIEDSPKKKTAPKKEKASPKKKKDDANESMVMTEEDRNVFTSIDKKGGGSKQMAIEDIYQKKSQLEHILLRPDTYIGSVEHTEKTPMWVYNMEESKLEQRDISYVPGLYKIYDEILVNAADNKQRDPKMNTIKITINKEKNEISVYNNGKGIPVTQHKVEKVYVPELIFGTLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTKFTLETSSRDYKSAFKQTWIKNMTRDEEPKIVKSTDEDFTKITFSPDLAKFKMKELDDDICHLMARRAYDVAGSSKGVAVFLNGKRIPIKGFEDYVQMYTSQFNNEGEPLKIAYEQVGDRWQVALALSEKGFQQVSFVNSIATTKGGRHVDYVADQMVAKFIDSIKRKLTKTSMNIKPFQIKNHMWVFVNCLIENPTFDSQTKETMTLQQKQFGSTCVLSEKFSKAASSVGITDAVMSWVRFKQMDDLNKKCSKTKTSKLKGIPKLEDANDAGTKNSQQCTLILTEGDSAKTLAVSGLSVVGRDKYGVFPLRGKLLNVREGNMKQIADNAEVNAMIKILGLQYKKKYETEDDFKTLRYGKLMVMADQDQDGSHIKGLVINFIHHFWPSLIQRNFVEEFITPIVKATKGKEEVSFYSLPEYSEWRMNTDNWKSYKIKYYKGLGTSTSKEAKEYFLDMVRHRIRFKYNGADDDNAVDMAFSKKKIEERKDWLSKWMREKKDRKQQGLAEEYLYNKDTRFVTFKDFVNRELVLFSNLDNERSIPCLVDGFKPGQRKVLFACFKRADKREVKVAQLAGAVAEISAYHHGEQSLMGTIVNLAQDYVGSNNINLLLPIGQFGTRLQGGKDSASARYIFTQLSPVTRTLFPAHDDNVLRFLYEENQRIEPEWYCPIIPMVLVNGAQGIGTGWSTNIPNYNPRELVKNIKRLIAGEPQKALAPWYKNFRGKIIQIDPSRFACYGEVAVLDDNTIEITELPIKQWTQDYKEKVLEGLMESSDKKSPVIVDYKEYHTDTTVKFVVKLSPGKLRELERGQDLHQVFKLQAVINTTCMVLFDAAGCLRTYTSPEAITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLTNQARFILAKINNEIVLENKKKAAIVDVLIKMKFDADPVKKWKEEQKLKELRESGEIELDEDDLAAVAVEEDEAISSAAKAVETKLSDYDYLVGMALIKLSEEEKNKLIKESEEKMAEVRVIEKKTWQDLWHEDLDNFVSELDKQEAREKADQDASIKNAAKKLAADAKTGRGPKKNVCTEVLPSKDGQRIEPMLDAATKAKYEKMSQPKKERVKKEPKEPKEPKKVKKEGQDIKKFMSPAAPKTAKKEKSDGFNSDMSEESDVEFDEGIDFDSDDDGVEREDVVSKPKPRTGKGAAKAEVIDLSDDDEVPAKKPAPAKKAAPKKKKSEFSDLSGGDSDEEAEKKPSTSKKPSPKKAAPKTAEPKSKAVTDFFGASKKNGKKAAGSDDEDDESFVVAPREKSGRARKAPPTYDVDSGSDSDQPKKKRGRVVDSDSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDSDSEFS ------CCCCCCCCC	58.06	19530675
4	Phosphorylation	----MSDSDSEFSIE ----CCCCCCCCCCC	52.94	28854356
6	Phosphorylation	--MSDSDSEFSIEDS --CCCCCCCCCCCCC	44.48	19530675
9	Phosphorylation	SDSDSEFSIEDSPKK CCCCCCCCCCCCCCC	22.48	19530675
26	Phosphorylation	APKKEKASPKKKKDD CCCCCCCCCCCCCCC	48.60	19530675
37	Phosphorylation	KKDDANESMVMTEED CCCCCCCCCCCCHHH	19.24	30078680
1323	Phosphorylation	QDIKKFMSPAAPKTA CCHHHHCCCCCCCCC	17.96	28854356
1389	Phosphorylation	KAEVIDLSDDDEVPA EEEEECCCCCCCCCC	34.93	28854356
1412	Phosphorylation	AAPKKKKSEFSDLSG CCCCCCHHHCCCCCC	53.40	21082442
1415	Phosphorylation	KKKKSEFSDLSGGDS CCCHHHCCCCCCCCC	33.32	19060867
1418	Phosphorylation	KSEFSDLSGGDSDEE HHHCCCCCCCCCHHH	45.80	19060867
1422	Phosphorylation	SDLSGGDSDEEAEKK CCCCCCCCHHHHHHC	50.63	28854356
1470	Phosphorylation	NGKKAAGSDDEDDES CCCCCCCCCCCCCCC	36.84	28854356
1477	Phosphorylation	SDDEDDESFVVAPRE CCCCCCCCEEEECCH	30.27	30078680
1500	Phosphorylation	PPTYDVDSGSDSDQP CCCCCCCCCCCCCCC	39.79	28854356
1502	Phosphorylation	TYDVDSGSDSDQPKK CCCCCCCCCCCCCCC	37.58	28854356
1504	Phosphorylation	DVDSGSDSDQPKKKR CCCCCCCCCCCCCCC	39.58	28854356
1517	Phosphorylation	KRGRVVDSDSD---- CCCCCCCCCCC----	27.66	30078680
1519	Phosphorylation	GRVVDSDSD------ CCCCCCCCC------	49.53	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TOP2_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TOP2_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TOP2_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YMX1_CAEEL	K06H7.1	physical	18692475
PFD5_CAEEL	pfd-5	physical	18692475
TPM1_CAEEL	lev-11	physical	18692475
TPM3_CAEEL	lev-11	physical	18692475

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.