dbPTM

TLE1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TLE1_MOUSE
UniProt AC	Q62440
Protein Name	Transducin-like enhancer protein 1
Gene Name	Tle1
Organism	Mus musculus (Mouse).
Sequence Length	770
Subcellular Localization	Nucleus . Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components. Isoform 7: Nucleus. Cytoplasm. Isoform 8: Nucleus. Cytoplasm.
Protein Description	Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG (By similarity)..
Protein Sequence	MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSASLLALSSALSGQSHLAIKDDKKHHDAERHRDRESGTSNSLLVPDSLRSTDKRRNGPEFSSDIKKRKVDDKDNYDSDGDKSDDNLVVDVSNEDPSSPHASPTHSPRENGIDKNRLLKKDASGSPASTASSGSSSSLKSKEVSLHEKANTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAMEPLVNQAAAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYAGLHSMSPQMSAAAAAAAAAVVAYGRSPMVGFDPPPHMRVPSIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	FPQSRHPTPHQAAGQ CCCCCCCCCCCCCCC	27.55	21659604
235	Phosphorylation	KVDDKDNYDSDGDKS CCCCCCCCCCCCCCC	27.27	26525534
237	Phosphorylation	DDKDNYDSDGDKSDD CCCCCCCCCCCCCCC	32.88	23375375
242	Phosphorylation	YDSDGDKSDDNLVVD CCCCCCCCCCCEEEE	55.74	26525534
256	Phosphorylation	DVSNEDPSSPHASPT ECCCCCCCCCCCCCC	69.67	25338131
257	Phosphorylation	VSNEDPSSPHASPTH CCCCCCCCCCCCCCC	26.54	25338131
261	Phosphorylation	DPSSPHASPTHSPRE CCCCCCCCCCCCCCC	27.57	25338131
265	Phosphorylation	PHASPTHSPRENGID CCCCCCCCCCCCCCC	28.29	25338131
282	Phosphorylation	RLLKKDASGSPASTA HCCCCCCCCCCCCCC	50.35	23984901
284	Phosphorylation	LKKDASGSPASTASS CCCCCCCCCCCCCCC	18.13	25521595
287	Phosphorylation	DASGSPASTASSGSS CCCCCCCCCCCCCCC	28.08	25619855
288	Phosphorylation	ASGSPASTASSGSSS CCCCCCCCCCCCCCC	32.44	25619855
290	Phosphorylation	GSPASTASSGSSSSL CCCCCCCCCCCCCCC	35.01	25619855
291	Phosphorylation	SPASTASSGSSSSLK CCCCCCCCCCCCCCC	39.98	25619855
293	Phosphorylation	ASTASSGSSSSLKSK CCCCCCCCCCCCCCC	29.06	25619855
294	Phosphorylation	STASSGSSSSLKSKE CCCCCCCCCCCCCCC	27.72	25619855
295	Phosphorylation	TASSGSSSSLKSKEV CCCCCCCCCCCCCCE	41.19	25619855
296	Phosphorylation	ASSGSSSSLKSKEVS CCCCCCCCCCCCCEE	41.59	25619855
300	Acetylation	SSSSLKSKEVSLHEK CCCCCCCCCEEHHHH	61.62	7718553
310	Phosphorylation	SLHEKANTPVLKSST EHHHHCCCCCCCCCC	21.45	19060867
314	Acetylation	KANTPVLKSSTPTPR HCCCCCCCCCCCCCC	42.46	7718563
544	Phosphorylation	KLLPDGCTLIVGGEA CCCCCCCEEEECCCC	25.67	-
703	Phosphorylation	LHESCVLSLKFAYCG EECHHHHEEEEECCC	14.76	30387612
718	Ubiquitination	KWFVSTGKDNLLNAW CEEHHCCHHHHHHHH	43.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
237	S	Phosphorylation	Kinase	CK2	-	Uniprot
257	S	Phosphorylation	Kinase	CDK1	P11440	Uniprot
261	S	Phosphorylation	Kinase	CDK1	P11440	Uniprot
265	S	Phosphorylation	Kinase	CDK1	P11440	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TLE1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TLE1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FOXG1_MOUSE	Foxg1	physical	11238932
TLE1_MOUSE	Tle1	physical	20211142
HES6_MOUSE	Hes6	physical	20211142
TLE1_MOUSE	Tle1	physical	12359720
ATF2_MOUSE	Atf2	physical	22439931
SSXT_MOUSE	Ss18	physical	22439931
HDAC1_MOUSE	Hdac1	physical	22439931
EZH2_MOUSE	Ezh2	physical	22439931

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TLE1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282, AND MASSSPECTROMETRY.	17242355 [Abstract]