THOC5_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THOC5_DROME
• UniProt AC: Q9W1F4
• Protein Name: THO complex subunit 5
• Gene Name: thoc5
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 616
• Subcellular Localization: Nucleus. Cytoplasm. Shuttles between nucleus and cytoplasm..
• Protein Description: The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress..
• Protein Sequence: METILNTQFDQLQKAIEGIKEAKSKGQSTDEARIATTLMFVALKHANREVKHKIKAGRDKLHLEKCKVDLSRLQLQNLLYEVSHLKKEIVRCQKFKSRDTSLELLSEAEYSSELPDMPNDAEELSSHKQHLHRLDCELRLRKALDKQYSALLSSKQELLQDNLSHAQRYVSFAPALRTLQSATKPLHDALQLSLDVEWKLSAVVKYLPKPLYVLFIVLQSLQRVSEEQSFTAEVVGYESEAQMQELLKEKKCSTLNYRQTKKESGDREKIADKNNLDDSLAPHPLHICLTIGAAGSNQLVLQIRYFDFIKCATVWGQLNCSRNANGQGDTNFVHHLLRHLYPNDLGNELPIPGIQYELRSSDLTAEECVRYLKAKDYGKPFCWLQSMCSIATVNSSMLYKHELNLNKNNKEIIDRIARRLNSWQRLSQQIRGLTFKDIDLYSLQENIYPAGLSCSLVQWTAITHEELHSQISDALNSSSADKGITYNSYRAVIVRGSAKMECFIRIPSNYPLEMPLWILNVHWNGCLTAQNNSAIKMMEFWTNSLQPKHLEPNDCILYAQLFRTIYSFDIFLETEGSMQNTIEYNKEKPYISAFAKRSRSRPYKYIKKGSVYAFKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
237	Phosphorylation	FTAEVVGYESEAQMQ CEEEECCCCCHHHHH	12.50	18327897
610	Phosphorylation	YKYIKKGSVYAFKQ- CEEEECCCEEEECC-	22.34	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THOC5_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THOC5_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THOC5_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DX39B_DROME	Hel25E	physical	27036967
CUFF_DROME	cuff	physical	27036967
ENY2_DROME	e(y)2	physical	20048002

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-237, AND MASSSPECTROMETRY.
PubMed: 18327897