| UniProt ID | TGFB2_HUMAN | |
|---|---|---|
| UniProt AC | P61812 | |
| Protein Name | Transforming growth factor beta-2 | |
| Gene Name | TGFB2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 414 | |
| Subcellular Localization | Secreted. | |
| Protein Description | TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.. | |
| Protein Sequence | MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 46 | Phosphorylation | AIRGQILSKLKLTSP HHHHHHHHHHCCCCC | 37.26 | 24719451 | |
| 72 | N-linked_Glycosylation | PEVISIYNSTRDLLQ HHHHHHHHCHHHHHH | 34.92 | UniProtKB CARBOHYD | |
| 81 | Ubiquitination | TRDLLQEKASRRAAA HHHHHHHHHHHHHHH | 38.41 | - | |
| 98 | Phosphorylation | RERSDEEYYAKEVYK HHCCCHHHHHHEEEE | 13.48 | - | |
| 123 | Phosphorylation | NAIPPTFYRPYFRIV CCCCCCCCCCCEEEE | 17.10 | 18083107 | |
| 140 | N-linked_Glycosylation | DVSAMEKNASNLVKA EHHHHHHCHHHHHHH | 34.98 | UniProtKB CARBOHYD | |
| 188 | Ubiquitination | TQRYIDSKVVKTRAE CHHHCCCEEEECCCC | 47.50 | - | |
| 241 | N-linked_Glycosylation | SNNYIIPNKSEELEA CCCEECCCCCHHHHH | 50.50 | UniProtKB CARBOHYD | |
| 275 | Phosphorylation | KSTRKKNSGKTPHLL CCCCCCCCCCCCHHH | 51.01 | 29083192 | |
| 278 | Phosphorylation | RKKNSGKTPHLLLML CCCCCCCCCHHHHHH | 21.33 | 29083192 | |
| 288 | Phosphorylation | LLLMLLPSYRLESQQ HHHHHHHHHHHHHHH | 23.89 | 24719451 | |
| 289 | Phosphorylation | LLMLLPSYRLESQQT HHHHHHHHHHHHHHH | 19.78 | 29083192 | |
| 293 | Phosphorylation | LPSYRLESQQTNRRK HHHHHHHHHHHHHHH | 31.98 | 29083192 | |
| 296 | Phosphorylation | YRLESQQTNRRKKRA HHHHHHHHHHHHHHH | 24.05 | 29083192 | |
| 333 | Ubiquitination | FKRDLGWKWIHEPKG EEHHHCCEECCCCCC | 34.18 | - | |
| 341 | Phosphorylation | WIHEPKGYNANFCAG ECCCCCCCCCCCCCC | 19.75 | - | |
| 352 | Phosphorylation | FCAGACPYLWSSDTQ CCCCCCCCCCCCCCC | 22.23 | - | |
| 404 | Phosphorylation | TPKIEQLSNMIVKSC CCCHHHHHHHHHHHC | 24.85 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TGFB2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TGFB2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TGFB2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PGS2_HUMAN | DCN | physical | 9675033 | |
| A4_HUMAN | APP | physical | 25241761 | |
| BMP2_HUMAN | BMP2 | physical | 25241761 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| Note=A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1 | ||||||
| 7)(q41 | ||||||
| p21) with HDAC9. | ||||||
| 614816 | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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