TGDS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TGDS_HUMAN
• UniProt AC: O95455
• Protein Name: dTDP-D-glucose 4,6-dehydratase
• Gene Name: TGDS
• Organism: Homo sapiens (Human).
• Sequence Length: 350
• Protein Sequence: MSAACWEEPWGLPGGFAKRVLVTGGAGFIASHMIVSLVEDYPNYMIINLDKLDYCASLKNLETISNKQNYKFIQGDICDSHFVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVSAAHEARVEKFIYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAECFVQSYWEQYKFPVVITRSSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGSGLQTRNFLYATDVVEAFLTVLKKGKPGEIYNIGTNFEMSVVQLAKELIQLIKETNSESEMENWVDYVNDRPTNDMRYPMKSEKIHGLGWRPKVPWKEGIKKTIEWYRENFHNWKNVEKALEPFPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Ubiquitination	GLPGGFAKRVLVTGG CCCCCCCCEEEEECC	40.55	-
27	Ubiquitination	VLVTGGAGFIASHMI EEEECCCHHHHHHHH	20.12	29967540
35	Ubiquitination	FIASHMIVSLVEDYP HHHHHHHHHHHHHCC	2.55	22817900
39	Ubiquitination	HMIVSLVEDYPNYMI HHHHHHHHHCCCEEE	58.06	22817900
41	Phosphorylation	IVSLVEDYPNYMIIN HHHHHHHCCCEEEEE	4.66	28787133
44	Phosphorylation	LVEDYPNYMIINLDK HHHHCCCEEEEEHHH	5.79	28787133
59	Ubiquitination	LDYCASLKNLETISN HCCCHHCCCHHHHCC	57.92	29967540
67	Ubiquitination	NLETISNKQNYKFIQ CHHHHCCCCCCEEEC	32.88	21906983
71	Ubiquitination	ISNKQNYKFIQGDIC HCCCCCCEEECCCCC	43.47	22817900
128	Ubiquitination	GTHVLVSAAHEARVE CCEEEEEHHHHHHCE	12.83	22817900
138	Ubiquitination	EARVEKFIYVSTDEV HHHCEEEEEEECCCC	5.00	21963094
153	Ubiquitination	YGGSLDKEFDESSPK CCCCCCCCCCCCCCC	58.98	21963094
160	Ubiquitination	EFDESSPKQPTNPYA CCCCCCCCCCCCCCC	71.50	21906983
170	Ubiquitination	TNPYASSKAAAECFV CCCCCCHHHHHHHHH	39.28	21963094
173	Ubiquitination	YASSKAAAECFVQSY CCCHHHHHHHHHHHH	20.96	29967540
185	Ubiquitination	QSYWEQYKFPVVITR HHHHHHHCCCEEEEC	42.77	21963094
205	Ubiquitination	GPHQYPEKVIPKFIS CCCCCCCHHHHHHHH	40.74	29967540
209	Ubiquitination	YPEKVIPKFISLLQH CCCHHHHHHHHHHHC	44.18	-
219	Ubiquitination	SLLQHNRKCCIHGSG HHHHCCCCEECCCCC	38.48	-
250	Ubiquitination	LTVLKKGKPGEIYNI HHHHHHCCCCCEEEE	59.74	-
273	Ubiquitination	VQLAKELIQLIKETN HHHHHHHHHHHHHCC	3.08	27667366
276	Ubiquitination	AKELIQLIKETNSES HHHHHHHHHHCCCHH	1.86	29967540
279	Phosphorylation	LIQLIKETNSESEME HHHHHHHCCCHHHHH	38.76	-
281	Phosphorylation	QLIKETNSESEMENW HHHHHCCCHHHHHHH	50.33	-
291	Phosphorylation	EMENWVDYVNDRPTN HHHHHHHHHCCCCCC	7.48	-
305	Ubiquitination	NDMRYPMKSEKIHGL CCCCCCCCCCCCCCC	51.46	27667366
307	Ubiquitination	MRYPMKSEKIHGLGW CCCCCCCCCCCCCCC	50.98	22817900
308	Ubiquitination	RYPMKSEKIHGLGWR CCCCCCCCCCCCCCC	47.28	29967540
311	Ubiquitination	MKSEKIHGLGWRPKV CCCCCCCCCCCCCCC	29.38	22817900
339	Ubiquitination	RENFHNWKNVEKALE HHHHCCCCCHHHHHC	57.33	22817900
343	Ubiquitination	HNWKNVEKALEPFPV CCCCCHHHHHCCCCC	54.73	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TGDS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TGDS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TGDS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
POTEE_HUMAN	POTEE	physical	28514442
MTF2_HUMAN	MTF2	physical	28514442
GBRAP_HUMAN	GABARAP	physical	28514442
TCAF1_HUMAN	FAM115A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616145: Catel-Manzke syndrome (CATMANS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.