TFEC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TFEC_HUMAN
• UniProt AC: O14948
• Protein Name: Transcription factor EC
• Gene Name: TFEC
• Organism: Homo sapiens (Human).
• Sequence Length: 347
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form..
• Protein Sequence: MTLDHQIINPTLKWSQPAVPSGGPLVQHAHTTLDSDAGLTENPLTKLLAIGKEDDNAQWHMEDVIEDIIGMESSFKEEGADSPLLMQRTLSGSILDVYSGEQGISPINMGLTSASCPSSLPMKREITETDTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGTILKASVEYIKWLQKEQQRARELEHRQKKLEQANRRLLLRIQELEIQARTHGLPTLASLGTVDLGAHVTKQQSHPEQNSVDYCQQLTVSQGPSPELCDQAIAFSDPLSYFTDLSFSAALKEEQRLDGMLLDDTISPFGTDPLLSATSPAVSKESSRRSSFSSDDGDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTLDHQIIN ------CCCCCCCCC	40.67	-
15	Phosphorylation	INPTLKWSQPAVPSG CCCCCCCCCCCCCCC	25.38	24719451
24 (in isoform 4)	Phosphorylation	-	32.65	22210691
35	Phosphorylation	HAHTTLDSDAGLTEN ECCCCCCCCCCCCCC	32.26	24719451
40	Phosphorylation	LDSDAGLTENPLTKL CCCCCCCCCCCHHHH	32.57	24719451
51 (in isoform 4)	Phosphorylation	-	22.99	22210691
52 (in isoform 4)	Phosphorylation	-	52.43	22210691
89	Phosphorylation	SPLLMQRTLSGSILD CCCEEEHHHCCCEEE	14.37	27251275
91	Phosphorylation	LLMQRTLSGSILDVY CEEEHHHCCCEEEEC	29.86	27251275
93	Phosphorylation	MQRTLSGSILDVYSG EEHHHCCCEEEECCC	19.32	27251275
111	Ubiquitination	ISPINMGLTSASCPS CCCCCCCCCCCCCCC	2.08	30230243
119	Phosphorylation	TSASCPSSLPMKREI CCCCCCCCCCCCCCC	22.95	-
149	Ubiquitination	DNHNLIERRRRYNIN HCCCHHHHHHHHCCC	30.34	30230243
178	Ubiquitination	DPDMRWNKGTILKAS CCCCCCCHHHHHHHH	50.93	30230243
318	Phosphorylation	DTISPFGTDPLLSAT CCCCCCCCCCCCCCC	34.52	22115753
323	Phosphorylation	FGTDPLLSATSPAVS CCCCCCCCCCCCCCC	36.86	22115753
325	Phosphorylation	TDPLLSATSPAVSKE CCCCCCCCCCCCCCH	31.69	22115753
326	Phosphorylation	DPLLSATSPAVSKES CCCCCCCCCCCCCHH	15.58	22115753
330	Phosphorylation	SATSPAVSKESSRRS CCCCCCCCCHHHCCC	32.58	22115753
333	Phosphorylation	SPAVSKESSRRSSFS CCCCCCHHHCCCCCC	32.64	20068231
334	Phosphorylation	PAVSKESSRRSSFSS CCCCCHHHCCCCCCC	32.57	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TFEC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TFEC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TFEC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFEC_HUMAN	TFEC	physical	11467950
TFE3_HUMAN	TFE3	physical	11467950
ZMAT2_HUMAN	ZMAT2	physical	21988832
SNAB_HUMAN	NAPB	physical	25416956
DB127_HUMAN	DEFB127	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.