TFB3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TFB3_SCHPO
• UniProt AC: O94684
• Protein Name: RNA polymerase II transcription factor B subunit 3
• Gene Name: pmh1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 318
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase activity and DNA-dependent ATPase activity, and is essential for polymerase II transcription (By similarity)..
• Protein Sequence: MDDEGARKVDEKCPLCQADRYLNPNMKLLINPECYHKMCESCVDRIFTTGPAQCPTPGCNKILRKAKFREQTFEDAQIEREVDVRKRISRIFNKGQQEFDSLQAYNDYLEEVEILTFNLIYKIDVEETEEKVKQYEKQNRDSIAANSARAAAEARILAQNEILLKRQKQEAREAAIREHQKEKERREQVEQQIIFDLATSGKDPNKIIQLSDSLKKQQENIASSVSNISRSSSILLSDVQQVAEDTTPFSPLAGEKDGSKYFSYSKNTYQDLYLEKVSHEPGRKCGFRIEDCHLRCLYEAFSGIDYDLESLKKLEVAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
224	Phosphorylation	QQENIASSVSNISRS HHHHHHHHHHHHHHH	22.12	25720772
226	Phosphorylation	ENIASSVSNISRSSS HHHHHHHHHHHHHHC	30.32	29996109
229	Phosphorylation	ASSVSNISRSSSILL HHHHHHHHHHHCCHH	30.29	29996109
231	Phosphorylation	SVSNISRSSSILLSD HHHHHHHHHCCHHHH	22.96	25720772
232	Phosphorylation	VSNISRSSSILLSDV HHHHHHHHCCHHHHH	21.93	25720772
233	Phosphorylation	SNISRSSSILLSDVQ HHHHHHHCCHHHHHH	20.64	25720772
250	Phosphorylation	AEDTTPFSPLAGEKD HCCCCCCCCCCCCCC	21.87	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TFB3_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TFB3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TFB3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CRK1_SCHPO	mcs6	physical	14534314
CGM2_SCHPO	mcs2	physical	14534314
ACT_SCHPO	act1	physical	14534314
SKP1_SCHPO	skp1	physical	15555586

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.