TDG_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TDG_MOUSE
• UniProt AC: P56581
• Protein Name: G/T mismatch-specific thymine DNA glycosylase
• Gene Name: Tdg
• Organism: Mus musculus (Mouse).
• Sequence Length: 421
• Subcellular Localization: Nucleus.
• Protein Description: DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. [PubMed: 21817016 Cannot remove 5-hydroxymethylcytosine (5hmC According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC]
• Protein Sequence: MDAEAARSYSLEQVQALYSFPFQQMMAEVPNMAVTTGQQVPAVAPNMATVTEQQVPEDAPVQEPAPEAPKRRKRKPRAAEPQEPVEPKKPATSKKSGKSTKSKEKQEKITDAFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNADVQEVQYTFDLQLAQEDAKKMAVKEEKYDPGYEAAYGGAYGENPCNGEPCGIASNGLTAHSAEPRGEAAPSDVPNGQWMAQSFAEQIPSFNNCGTREQEEESHA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Acetylation	EPAPEAPKRRKRKPR CCCCCCCHHHCCCCC	46.75	11864601
94	Acetylation	PKKPATSKKSGKSTK CCCCCCCCCCCCCCC	42.65	11864601
95	Acetylation	KKPATSKKSGKSTKS CCCCCCCCCCCCCCC	8.09	11864601
96	Phosphorylation	KPATSKKSGKSTKSK CCCCCCCCCCCCCCH	53.11	-
98	Acetylation	ATSKKSGKSTKSKEK CCCCCCCCCCCCHHH	8.92	11864601
99	Phosphorylation	TSKKSGKSTKSKEKQ CCCCCCCCCCCHHHH	51.34	-
212	Malonylation	ERTTPGSKDLSSKEF EECCCCCCCCCCHHH	17.61	26320211
341	Sumoylation	DAKKMAVKEEKYDPG HHHHHHHHHHHCCCC	24.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
96	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
99	S	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
341	K	Sumoylation	Sumoylation on Lys-341 by either SUMO1 or SUMO2 induces dissociation of the product DNA.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TDG_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNM3A_HUMAN	DNMT3A	physical	17175537
AICDA_MOUSE	Aicda	physical	21722948
GA45A_MOUSE	Gadd45a	physical	21722948
LEF1_MOUSE	Lef1	physical	24748645

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.