TCPR2_HUMAN - dbPTM
TCPR2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TCPR2_HUMAN
UniProt AC O15040
Protein Name Tectonin beta-propeller repeat-containing protein 2
Gene Name TECPR2
Organism Homo sapiens (Human).
Sequence Length 1411
Subcellular Localization
Protein Description Probably plays a role as positive regulator of autophagy..
Protein Sequence MASISEPVTFREFCPLYYLLNAIPTKIQKGFRSIVVYLTALDTNGDYIAVGSSIGMLYLYCRHLNQMRKYNFEGKTESITVVKLLSCFDDLVAAGTASGRVAVFQLVSSLPGRNKQLRRFDVTGIHKNSITALAWSPNGMKLFSGDDKGKIVYSSLDLDQGLCNSQLVLEEPSSIVQLDYSQKVLLVSTLQRSLLFYTEEKSVRQIGTQPRKSTGKFGACFIPGLCKQSDLTLYASRPGLRLWKADVHGTVQATFILKDAFAGGVKPFELHPRLESPNSGSCSLPERHLGLVSCFFQEGWVLSWNEYSIYLLDTVNQATVAGLEGSGDIVSVSCTENEIFFLKGDRNIIRISSRPEGLTSTVRDGLEMSGCSERVHVQQAEKLPGATVSETRLRGSSMASSVASEPRSRSSSLNSTDSGSGLLPPGLQATPELGKGSQPLSQRFNAISSEDFDQELVVKPIKVKRKKKKKKTEGGSRSTCHSSLESTPCSEFPGDSPQSLNTDLLSMTSSVLGSSVDQLSAESPDQESSFNGEVNGVPQENTDPETFNVLEVSGSMPDSLAEEDDIRTEMPHCHHAHGRELLNGAREDVGGSDVTGLGDEPCPADDGPNSTQLPFQEQDSSPGAHDGEDIQPIGPQSTFCEVPLLNSLTVPSSLSWAPSAEQWLPGTRADEGSPVEPSQEQDILTSMEASGHLSTNLWHAVTDDDTGQKEIPISERVLGSVGGQLTPVSALAASTHKPWLEQPPRDQTLTSSDEEDIYAHGLPSSSSETSVTELGPSCSQQDLSRLGAEDAGLLKPDQFAESWMGYSGPGYGILSLVVSEKYIWCLDYKGGLFCSALPGAGLRWQKFEDAVQQVAVSPSGALLWKIEQKSNRAFACGKVTIKGKRHWYEALPQAVFVALSDDTAWIIRTSGDLYLQTGLSVDRPCARAVKVDCPYPLSQITARNNVVWALTEQRALLYREGVSSFCPEGEQWKCDIVSERQALEPVCITLGDQQTLWALDIHGNLWFRTGIISKKPQGDDDHWWQVSITDYVVFDQCSLFQTIIHATHSVATAAQAPVEKVADKLRMAFWSQQLQCQPSLLGVNNSGVWISSGKNEFHVAKGSLIGTYWNHVVPRGTASATKWAFVLASAAPTKEGSFLWLCQSSKDLCSVSAQSAQSRPSTVQLPPEAEMRAYAACQDALWALDSLGQVFIRTLSKSCPTGMHWTRLDLSQLGAVKLTSLACGNQHIWACDSRGGVYFRVGTQPLNPSLMLPAWIMIEPPVQPAGVSLVSVHSSPNDQMLWVLDSRWNVHVRTGITEEMPVGTAWEHVPGLQACQLALSTRTVWARCPNGDLARRYGVTDKNPAGDYWKKIPGSVSCFTVTASDELWAVGPPGYLLQRLTKTFSHSHGTQKSSQAAMPHPEDLEDEWEVI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MASISEPVTF
-----CCCCCCCCCH		38.2127251275
33PhosphorylationKIQKGFRSIVVYLTA
HHHHCCCEEEEEEEE		19.9223403867
37PhosphorylationGFRSIVVYLTALDTN
CCCEEEEEEEEECCC		6.35-
39PhosphorylationRSIVVYLTALDTNGD
CEEEEEEEEECCCCC		13.9023403867
43PhosphorylationVYLTALDTNGDYIAV
EEEEEECCCCCEEEE		41.7823403867
47PhosphorylationALDTNGDYIAVGSSI
EECCCCCEEEEEHHH		7.68-
52PhosphorylationGDYIAVGSSIGMLYL
CCEEEEEHHHHHHHH		16.5123403867
58PhosphorylationGSSIGMLYLYCRHLN
EHHHHHHHHHHHHHH		6.17-
60PhosphorylationSIGMLYLYCRHLNQM
HHHHHHHHHHHHHHH		3.63-
136PhosphorylationSITALAWSPNGMKLF
CCEEEEECCCCCCCC		11.6829083192
180PhosphorylationSSIVQLDYSQKVLLV
CCEEECCCCCHHHHH		22.9226074081
181PhosphorylationSIVQLDYSQKVLLVS
CEEECCCCCHHHHHH		24.1626074081
188PhosphorylationSQKVLLVSTLQRSLL
CCHHHHHHHHHHHHH		24.3026074081
189PhosphorylationQKVLLVSTLQRSLLF
CHHHHHHHHHHHHHH		21.3026074081
193PhosphorylationLVSTLQRSLLFYTEE
HHHHHHHHHHHHCCC		19.2326074081
197PhosphorylationLQRSLLFYTEEKSVR
HHHHHHHHCCCHHHH		17.1426074081
208PhosphorylationKSVRQIGTQPRKSTG
HHHHHCCCCCCCCCC		36.7123898821
276PhosphorylationELHPRLESPNSGSCS
EECCCCCCCCCCCCC		33.6921815630
279PhosphorylationPRLESPNSGSCSLPE
CCCCCCCCCCCCCCH		35.1528555341
352PhosphorylationDRNIIRISSRPEGLT
CCCEEEECCCCCCCC		15.5027282143
387PhosphorylationAEKLPGATVSETRLR
HHHCCCCEECCEECC		30.4027251275
387O-linked_GlycosylationAEKLPGATVSETRLR
HHHCCCCEECCEECC		30.4028657654
389PhosphorylationKLPGATVSETRLRGS
HCCCCEECCEECCCC		28.9728857561
396PhosphorylationSETRLRGSSMASSVA
CCEECCCCHHHHHHC		15.5425850435
397PhosphorylationETRLRGSSMASSVAS
CEECCCCHHHHHHCC		22.6125850435
401PhosphorylationRGSSMASSVASEPRS
CCCHHHHHHCCCCCC		16.50-
404PhosphorylationSMASSVASEPRSRSS
HHHHHHCCCCCCCCC		46.0828102081
408PhosphorylationSVASEPRSRSSSLNS
HHCCCCCCCCCCCCC		47.4324670416
410PhosphorylationASEPRSRSSSLNSTD
CCCCCCCCCCCCCCC		26.0623927012
411PhosphorylationSEPRSRSSSLNSTDS
CCCCCCCCCCCCCCC		37.4228111955
412PhosphorylationEPRSRSSSLNSTDSG
CCCCCCCCCCCCCCC		32.5826657352
415PhosphorylationSRSSSLNSTDSGSGL
CCCCCCCCCCCCCCC		38.5928111955
416PhosphorylationRSSSLNSTDSGSGLL
CCCCCCCCCCCCCCC		32.8632142685
418PhosphorylationSSLNSTDSGSGLLPP
CCCCCCCCCCCCCCC		34.6423927012
420PhosphorylationLNSTDSGSGLLPPGL
CCCCCCCCCCCCCCC		30.1628111955
437PhosphorylationTPELGKGSQPLSQRF
CCCCCCCCCCHHHHH		31.9123532336
448PhosphorylationSQRFNAISSEDFDQE
HHHHCCCCCCCCCHH		25.8422617229
449PhosphorylationQRFNAISSEDFDQEL
HHHCCCCCCCCCHHH		34.7622617229
470UbiquitinationVKRKKKKKKTEGGSR
ECCCCCCCCCCCCCC		74.0324816145
472PhosphorylationRKKKKKKTEGGSRST
CCCCCCCCCCCCCCC		49.06-
486PhosphorylationTCHSSLESTPCSEFP
CCHHCCCCCCCCCCC		42.83-
487PhosphorylationCHSSLESTPCSEFPG
CHHCCCCCCCCCCCC		20.95-
523PhosphorylationVDQLSAESPDQESSF
HHHHCCCCCCCHHHC		33.23-
673PhosphorylationGTRADEGSPVEPSQE
CCCCCCCCCCCCCHH		24.5923898821
720PhosphorylationISERVLGSVGGQLTP
CHHHCCCCCCCCCCC		17.2725850435
726PhosphorylationGSVGGQLTPVSALAA
CCCCCCCCCHHHHHH		17.4725850435
729PhosphorylationGGQLTPVSALAASTH
CCCCCCHHHHHHHCC		20.8326074081
734PhosphorylationPVSALAASTHKPWLE
CHHHHHHHCCCCHHC		25.9925850435
748PhosphorylationEQPPRDQTLTSSDEE
CCCCCCCCCCCCCHH		35.9729449344
750PhosphorylationPPRDQTLTSSDEEDI
CCCCCCCCCCCHHHH		29.5829116813
751PhosphorylationPRDQTLTSSDEEDIY
CCCCCCCCCCHHHHH		38.6129116813
752PhosphorylationRDQTLTSSDEEDIYA
CCCCCCCCCHHHHHH		43.7529116813
758PhosphorylationSSDEEDIYAHGLPSS
CCCHHHHHHCCCCCC		12.6026657352
764PhosphorylationIYAHGLPSSSSETSV
HHHCCCCCCCCCCCC		48.1428348404
765PhosphorylationYAHGLPSSSSETSVT
HHCCCCCCCCCCCCC		35.6228348404
766PhosphorylationAHGLPSSSSETSVTE
HCCCCCCCCCCCCCC		36.2128348404
767PhosphorylationHGLPSSSSETSVTEL
CCCCCCCCCCCCCCC		47.0128348404
769PhosphorylationLPSSSSETSVTELGP
CCCCCCCCCCCCCCC		30.3728348404
770PhosphorylationPSSSSETSVTELGPS
CCCCCCCCCCCCCCC		24.0028348404
772PhosphorylationSSSETSVTELGPSCS
CCCCCCCCCCCCCCC		25.8428348404
859PhosphorylationQQVAVSPSGALLWKI
HHHEECCCCCEEEEE		29.23-
882UbiquitinationACGKVTIKGKRHWYE
EEEEEEECCCCHHHH		49.35-
884UbiquitinationGKVTIKGKRHWYEAL
EEEEECCCCHHHHHC		35.77-
1013PhosphorylationWFRTGIISKKPQGDD
EEEEEEEECCCCCCC		32.4824719451
1103PhosphorylationEFHVAKGSLIGTYWN
EEEEECCCEEEEECC		18.99-
1348PhosphorylationDKNPAGDYWKKIPGS
CCCCCCCHHCCCCCC		20.43-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TCPR2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TCPR2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TCPR2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS41_HUMANVPS41physical
28514442
VPS18_HUMANVPS18physical
28514442
VPS16_HUMANVPS16physical
28514442
PPM1A_HUMANPPM1Aphysical
28514442
NUDC3_HUMANNUDCD3physical
28514442
DNJB5_HUMANDNAJB5physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615031Spastic paraplegia 49, autosomal recessive (SPG49)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TCPR2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448 AND SER-449, ANDMASS SPECTROMETRY.

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