TBX20_HUMAN - dbPTM
TBX20_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TBX20_HUMAN
UniProt AC Q9UMR3
Protein Name T-box transcription factor TBX20
Gene Name TBX20
Organism Homo sapiens (Human).
Sequence Length 447
Subcellular Localization Nucleus .
Protein Description Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart..
Protein Sequence MEFTASPKPQLSSRANAFSIAALMSSGGSKEKEATENTIKPLEQFVEKSSCAQPLGELTSLDAHGEFGGGSGSSPSSSSLCTEPLIPTTPIIPSEEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGGEEDVLGDESQTTPNRGSAFTTSDNLSLSSWVSSSSSFPGFQHPQSLTALGTSTASIATPIPHPIQGSLPPYSRLGMPLTPSAIASSMQGSGPTFPSFHMPRYHHYFQQGPYAAIQGLRHSSAVMTPFV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
118PhosphorylationDKFHELGTEMIITKS
HHHHHHCCEEEEECC		34.70-
146PhosphorylationGVDPEAKYIVLMDIV
CCCCCCCEEEEEEEE		11.8721964256
160PhosphorylationVPVDNKRYRYAYHRS
EECCCCEEEEEEECC		15.0221964256
167PhosphorylationYRYAYHRSSWLVAGK
EEEEEECCCEEEECC		16.7425278378
168PhosphorylationRYAYHRSSWLVAGKA
EEEEECCCEEEECCC		25.1225278378
198UbiquitinationFTGEQLLKQMVSFEK
CCHHHHHHHHHCCEE		44.9621963094
284UbiquitinationIDSNPFAKGFRDSSR
ECCCCCCCCCCCCCC		59.9929967540
302PhosphorylationIERESVESLIQKHSY
HHHHHHHHHHHHHCC		28.7225159151
308PhosphorylationESLIQKHSYARSPIR
HHHHHHHCCCCCCCC		27.7629449344
309PhosphorylationSLIQKHSYARSPIRT
HHHHHHCCCCCCCCC		13.0229449344
312PhosphorylationQKHSYARSPIRTYGG
HHHCCCCCCCCCCCC		19.2624719451
316PhosphorylationYARSPIRTYGGEEDV
CCCCCCCCCCCCCCC		27.5130206219
317PhosphorylationARSPIRTYGGEEDVL
CCCCCCCCCCCCCCC		17.1830206219
331PhosphorylationLGDESQTTPNRGSAF
CCCCCCCCCCCCCCC		15.7827732954
398PhosphorylationSRLGMPLTPSAIASS
CCCCCCCCHHHHHHH		14.8828270605
400PhosphorylationLGMPLTPSAIASSMQ
CCCCCCHHHHHHHCC		27.3728270605
404PhosphorylationLTPSAIASSMQGSGP
CCHHHHHHHCCCCCC		21.8928270605
405PhosphorylationTPSAIASSMQGSGPT
CHHHHHHHCCCCCCC		13.2028270605
409PhosphorylationIASSMQGSGPTFPSF
HHHHCCCCCCCCCCC		25.3828270605
412PhosphorylationSMQGSGPTFPSFHMP
HCCCCCCCCCCCCCC		52.2628270605
415PhosphorylationGSGPTFPSFHMPRYH
CCCCCCCCCCCCCCH		24.4828270605
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TBX20_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TBX20_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TBX20_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZSCA1_HUMANZSCAN1physical
20211142
TLE1_HUMANTLE1physical
26186194
TLE3_HUMANTLE3physical
26186194
TLE4_HUMANTLE4physical
26186194
TLE4_HUMANTLE4physical
28514442
TLE3_HUMANTLE3physical
28514442
TLE1_HUMANTLE1physical
28514442
DNSL2_HUMANDNASE1L2physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TBX20_HUMAN

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Related Literatures of Post-Translational Modification

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