SYPH_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYPH_RAT
• UniProt AC: P07825
• Protein Name: Synaptophysin
• Gene Name: Syp
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 307
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .
• Protein Description: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)..
• Protein Sequence: MDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYTGELRLSVECANKTESALNIEVEFEYPFRLHQVYFDAPSCVKGGTTKIFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMMDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPMCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFMRAPPGAPEKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPASGGGGYGPQGDYGQQGYGQQGAPTSFSNQM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	N-linked_Glycosylation	RLSVECANKTESALN EEEEEECCCCCCCEE	64.54	-
75	Phosphorylation	PFRLHQVYFDAPSCV CEEEEEEEECCCCCC	6.81	30411139
163	Acetylation	AKGLSDVKMATDPEN HCCCCCCEECCCHHH	28.01	22902405
184	Phosphorylation	MCRQTGNTCKELRDP CCCCCCCCHHHHCCC	26.71	25403869
221	Phosphorylation	LWFVFKETGWAAPFM HHHHHHCCCCCCCCC	38.32	-
263	Phosphorylation	GYGPQDSYGPQGGYQ CCCCCCCCCCCCCCC	40.91	-
273	Phosphorylation	QGGYQPDYGQPASGG CCCCCCCCCCCCCCC	25.09	-
289	Phosphorylation	GYGPQGDYGQQGYGQ CCCCCCCCCCCCCCC	24.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Siah1	Q920M9	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	Siah2	Q8R4T2	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYPH_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYPH_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HGS_RAT	Hgs	physical	10825299
SNP25_RAT	Snap25	physical	10825299
SIAH1_RAT	Siah1	physical	11786535
SIAH2_RAT	Siah2	physical	11786535

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.