SPK1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPK1_CAEEL
• UniProt AC: Q03563
• Protein Name: Serine/threonine-protein kinase spk-1
• Gene Name: spk-1
• Organism: Caenorhabditis elegans.
• Sequence Length: 1003
• Protein Description: Required for embryogenesis and germline development in both adult hermaphrodites and males. SR-protein kinase (SRPK) that binds directly to and phosphorylates the RS domain of rsp-3/CeSF2 in vitro..
• Protein Sequence: MFVVLFCRWLNGFSQHRERLYKFEDEAVQRRRRFRVHSEESEELNDHESYSETDICTQLLASSADVTCHINVDLVNQNRFYFFVKQRNKKENSTNEEEEISSQEINTSTQNEETEVNLVFASAEDNGGVASNFDISDALMVTSNISEVSKLPETLCEEGETVQQKSVVNENDHSNEDDEQSLQSQDGSRCSDEDMNSCVSASDEEDVESQDDSFHVNDATEESIDSVSSIESQEAEESATEDLASCHSNDDKNEKDVLVDEDTSKYDNLPVEMRSAKEGEESEGTIDSSVSSSTSSSSTGDDGDDSATSYDSEDIEIQMFEYDLGTACASASISIPRPSIIPRNNKKTEVNANEERLDDLSVSPGRSDSPGGGGGGHSDSFQDPMDPGEQLGSDDEEQEDPRDYKRGGYHPVNIGDVFNARYHVIRKLGWGHFSTVWLAWDTQDKRFVAMKIVKSAEHYTEAALDEIKLLLSVRSADPNDIGCHKVVQLLDEFTVTGINGQHVAMVFEVLGCNLLKLIIRSNYRGLHLEQVRKICRQVLEALGYMHEKCGIIHTDIKPENVLITMSREEIKIMAQHAVVARKMNMKMSGSAVSTAPDHLVKMAQENMTKNKKKKMKKKAKKQREKLEAELAGLEGLKMDANGLQEAYNNAPELENFNASQVEDVTMEDTVNENGNRNKVEIRSPDRFDRTTLTPFSDPESKFGDLASPSAEYLSSPMSQLPPGGILPAPPVGPNIGDPYCDIDVKIADLGNACWVNHHYTDDIQTRQYRALEVLIGSGYGPPADIWSTACMAFELATGDYLFEPHQGDNYSRDEDHLAHISELLGAIPPSIYKKGKHWREFFHKNGHLLHIHQLKPWSLYEVLRQKYEWSHEDAQQFESFLRPMLDFDQEKRSTAKIALKHPFLLPFGGRAPKSDCPPELLSKMFPDGLIPEPFDGNEHQEVYRDENDSRSASERSANSRSAGGSDDDDEEEFNMNRPGPSGVITNNETTDISDIERFQLDLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31 (in isoform 2)	Phosphorylation	-	19.62	19530675
31 (in isoform 3)	Phosphorylation	-	19.62	19530675
33 (in isoform 2)	Phosphorylation	-	23.16	19530675
33 (in isoform 3)	Phosphorylation	-	23.16	19530675
34 (in isoform 2)	Phosphorylation	-	10.18	19530675
34 (in isoform 3)	Phosphorylation	-	10.18	19530675
363	Phosphorylation	RLDDLSVSPGRSDSP HHHHCCCCCCCCCCC	20.47	19530675
588	Phosphorylation	RKMNMKMSGSAVSTA HHCCCCCCCCCCCCC	24.87	19530675
590	Phosphorylation	MNMKMSGSAVSTAPD CCCCCCCCCCCCCHH	20.42	19530675
593	Phosphorylation	KMSGSAVSTAPDHLV CCCCCCCCCCHHHHH	20.68	19530675
683	Phosphorylation	RNKVEIRSPDRFDRT CCCEEECCCCCCCCC	36.49	28854356
690	Phosphorylation	SPDRFDRTTLTPFSD CCCCCCCCCCCCCCC	28.18	30078680
691	Phosphorylation	PDRFDRTTLTPFSDP CCCCCCCCCCCCCCC	29.54	30078680
693	Phosphorylation	RFDRTTLTPFSDPES CCCCCCCCCCCCCHH	21.86	30078680
696	Phosphorylation	RTTLTPFSDPESKFG CCCCCCCCCCHHHCC	54.16	30078680
700	Phosphorylation	TPFSDPESKFGDLAS CCCCCCHHHCCCCCC	38.38	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPK1_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPK1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPK1_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARF12_CAEEL	arf-1.2	physical	14704431
HSP90_CAEEL	daf-21	physical	14704431
NU301_CAEEL	nurf-1	physical	14704431

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.