HSP90_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSP90_CAEEL
• UniProt AC: Q18688
• Protein Name: Heat shock protein 90
• Gene Name: daf-21 {ECO:0000312|EMBL:CAA99793.1}
• Organism: Caenorhabditis elegans.
• Sequence Length: 702
• Subcellular Localization: Cytoplasm, perinuclear region . Perinuclear region of somatic cells.
• Protein Description: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another signal transduction component that regulates cGMP levels, plays a role in dauer formation and chemotaxis to non-volatile and volatile attractants detected by AWC sensory neurons. [PubMed: 10790386]
• Protein Sequence: MSENAETFAFQAEIAQLMSLIINTFYSNKEIYLRELISNASDALDKIRYQALTEPSELDTGKELFIKITPNKEEKTLTIMDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAFLVADKVVVTSKNNDDDSYQWESSAGGSFVVRPFNDPEVTRGTKIVMHIKEDQIDFLEERKIKEIVKKHSQFIGYPIKLVVEKEREKEVEDEEAVEAKDEEKKEGEVENVADDADKKKTKKIKEKYFEDEELNKTKPIWTRNPDDISNEEYAEFYKSLSNDWEDHLAVKHFSVEGQLEFRALLFVPQRAPFDLFENKKSKNSIKLYVRRVFIMENCEELMPEYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCMELIDEVAEDKDNFKKFYEQFGKNLKLGIHEDSTNRKKLSDFLRYSTSAGDEPTSLKEYVSRMKENQTQIYYITGESKDVVAASAFVERVKSRGFEVLYMCDPIDEYCVQQLKEYDGKKLVSVTKEGLELPETEEEKKKFEEDKVAYENLCKVIKDILEKKVEKVGVSNRLVSSPCCIVTSEYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHAIMKTLRDRVEVDKNDKTVKDLVVLLFETALLASGFSLEEPQSHASRIYRMIKLGLDIGDDEIEDSAVPSSCTAEAKIEGAEEDASRMEEVD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	DALDKIRYQALTEPS HHHHHHHHHHHCCHH	11.12	27067626
199	Phosphorylation	KEIVKKHSQFIGYPI HHHHHHHHHHCCCCE	35.35	22923814
286	Phosphorylation	EYAEFYKSLSNDWED HHHHHHHHHCCCHHH	26.17	30078680
288	Phosphorylation	AEFYKSLSNDWEDHL HHHHHHHCCCHHHCE	39.57	30078680
370	Phosphorylation	EDLPLNISREMLQQS CCCCCCCCHHHHHHH	22.55	30078680
431	Phosphorylation	STNRKKLSDFLRYST CCCHHHHHHHHHHHC	34.89	28854356
436	Phosphorylation	KLSDFLRYSTSAGDE HHHHHHHHHCCCCCC	20.60	30078680
437	Phosphorylation	LSDFLRYSTSAGDEP HHHHHHHHCCCCCCC	14.95	30078680
438	Phosphorylation	SDFLRYSTSAGDEPT HHHHHHHCCCCCCCC	17.42	30078680
574	Phosphorylation	CCIVTSEYGWSANME EEEEECCCCCCCCHH	24.54	27067626
696	Phosphorylation	EGAEEDASRMEEVD- CCCHHHHHHHCCCC-	44.47	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HSP90_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HSP90_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSP90_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP90_CAEEL	daf-21	physical	14992718
HSP90_CAEEL	daf-21	physical	18692475

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.