SMAKA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMAKA_HUMAN
• UniProt AC: Q9BSF0
• Protein Name: Small membrane A-kinase anchor protein
• Gene Name: C2orf88
• Organism: Homo sapiens (Human).
• Sequence Length: 95
• Subcellular Localization: Cell membrane . The GFP-tagged protein has been detected at the plasma membrane, enriched in filopodia and cell-cell junctions.
• Protein Description: Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane..
• Protein Sequence: MGCMKSKQTFPFPTIYEGEKQHESEEPFMPEERCLPRMASPVNVKEEVKEPPGTNTVILEYAHRLSQDILCDALQQWACNNIKYHDIPYIESEGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGCMKSKQT ------CCCCCCCCC		23115245
3	S-palmitoylation	-----MGCMKSKQTF -----CCCCCCCCCC		23115245
24	Phosphorylation	EGEKQHESEEPFMPE CCCCCCCCCCCCCCH		28270605
40	Phosphorylation	RCLPRMASPVNVKEE HCCCCCCCCCCCCHH		25262027
66	Phosphorylation	LEYAHRLSQDILCDA HHHHHHHCHHHHHHH		-
84	Phosphorylation	WACNNIKYHDIPYIE HHHCCCCHHCCCCCC		22817900
89	Phosphorylation	IKYHDIPYIESEGP- CCHHCCCCCCCCCC-		24927040
92	Phosphorylation	HDIPYIESEGP---- HCCCCCCCCCC----		23115245

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
66	S	Phosphorylation	Kinase	PRKACA	P00517	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
3	C	Palmitoylation	May be palmitoylated at Cys-3.	23115245

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMAKA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RGPS1_HUMAN	RALGPS1	physical	21988832
TYDP2_HUMAN	TDP2	physical	21988832
IKBL1_HUMAN	NFKBIL1	physical	21988832
MYOD1_HUMAN	MYOD1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.