RGPS1_HUMAN - dbPTM
RGPS1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RGPS1_HUMAN
UniProt AC Q5JS13
Protein Name Ras-specific guanine nucleotide-releasing factor RalGPS1
Gene Name RALGPS1
Organism Homo sapiens (Human).
Sequence Length 557
Subcellular Localization Cytoplasm . Cell membrane . Associates with membranes through the PH domain.
Protein Description Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for..
Protein Sequence MYKRNGLMASVLVTSATPQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSSPRLVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFSEEMSSGLESPTGPCICSLGNSAAVPTMEGPLRRKTLLKEGRKPALSSWTRYWVILSGSTLLYYGAKSLRGTDRKHYKSTPGKKVSIVGWMVQLPDDPEHPDIFQLNNPDKGNVYKFQTGSRFHAILWHKHLDDACKSNRPQVPANLMSFE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
39PhosphorylationCDYASKSYDAVVFDV
CCCCCCCCCEEEEEE		16.20-
86PhosphorylationWSKKEKHSLAPNVVA
CCHHHHCCCCCCEEE		36.9828555341
95 (in isoform 6)Phosphorylation-15.9322210691
140PhosphorylationLELNNLHSLMSVVSA
HHHCCHHHHHHHHHH		29.0027174698
143PhosphorylationNNLHSLMSVVSALQS
CCHHHHHHHHHHHHH		25.3522210691
146PhosphorylationHSLMSVVSALQSAPI
HHHHHHHHHHHHCCC		22.5527174698
150PhosphorylationSVVSALQSAPIFRLT
HHHHHHHHCCCHHHH		36.5427174698
157PhosphorylationSAPIFRLTKTWALLN
HCCCHHHHHHHHHHC		23.3627174698
159PhosphorylationPIFRLTKTWALLNRK
CCHHHHHHHHHHCCC		15.6727174698
169PhosphorylationLLNRKDKTTFEKLDY
HHCCCCCCHHHHHHH		47.02-
170PhosphorylationLNRKDKTTFEKLDYL
HCCCCCCHHHHHHHH		35.22-
185AcetylationMSKEDNYKRTREYIR
HCCCCCHHHHHHHHH		54.257668661
230PhosphorylationIMENEQRSNQMNNIL
HHCCHHHHHHHHHHH		30.9824719451
273UbiquitinationRYIEELQKFVEDDNY
HHHHHHHHHHHCCCC		65.0929967540
281UbiquitinationFVEDDNYKLSLRIEP
HHHCCCCEEEEEECC		37.5429967540
283PhosphorylationEDDNYKLSLRIEPGS
HCCCCEEEEEECCCC		16.0817322306
290PhosphorylationSLRIEPGSSSPRLVS
EEEECCCCCCCCEEC		38.0628348404
291PhosphorylationLRIEPGSSSPRLVSS
EEECCCCCCCCEECC		50.7228348404
292PhosphorylationRIEPGSSSPRLVSSK
EECCCCCCCCEECCC		18.7526437602
297PhosphorylationSSSPRLVSSKEDLAG
CCCCCEECCCCHHCC		40.0425849741
298PhosphorylationSSPRLVSSKEDLAGP
CCCCEECCCCHHCCC		32.3625849741
299UbiquitinationSPRLVSSKEDLAGPS
CCCEECCCCHHCCCC		47.9829967540
306PhosphorylationKEDLAGPSAGSGSAR
CCHHCCCCCCCCCCC		44.3226546556
309PhosphorylationLAGPSAGSGSARFSR
HCCCCCCCCCCCCCC		29.32-
311PhosphorylationGPSAGSGSARFSRRP
CCCCCCCCCCCCCCC		20.2624732914
319PhosphorylationARFSRRPTCPDTSVA
CCCCCCCCCCCCCCC		34.5524719451
323PhosphorylationRRPTCPDTSVAGSLP
CCCCCCCCCCCCCCC		15.3923312004
324PhosphorylationRPTCPDTSVAGSLPT
CCCCCCCCCCCCCCC		19.8323312004
328PhosphorylationPDTSVAGSLPTPPVP
CCCCCCCCCCCCCCC		22.8023312004
331PhosphorylationSVAGSLPTPPVPRHR
CCCCCCCCCCCCCCC		45.5824719451
340PhosphorylationPVPRHRKSHSLGNNM
CCCCCCCCCCCCCCC		20.4724719451
342PhosphorylationPRHRKSHSLGNNMMC
CCCCCCCCCCCCCEE		45.0928348404
351 (in isoform 7)Phosphorylation-3.4128796482
351 (in isoform 2)Phosphorylation-3.4128796482
353 (in isoform 2)Phosphorylation-8.23-
353 (in isoform 7)Phosphorylation-8.23-
360PhosphorylationVVESKSATFPSEKAR
EEECCCCCCCCHHHH		43.0726657352
365 (in isoform 2)Phosphorylation-55.8724719451
365 (in isoform 7)Phosphorylation-55.8724719451
370 (in isoform 3)Phosphorylation-5.8527174698
374 (in isoform 3)Phosphorylation-9.8927174698
375 (in isoform 3)Phosphorylation-5.9927174698
378 (in isoform 3)Phosphorylation-41.1127174698
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RGPS1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RGPS1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RGPS1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RALA_HUMANRALAphysical
10889189
GRB2_HUMANGRB2physical
10747847
NCK1_HUMANNCK1physical
10747847
A4_HUMANAPPphysical
21832049
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RGPS1_HUMAN

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Related Literatures of Post-Translational Modification

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