SIP1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIP1_SCHPO
• UniProt AC: O42998
• Protein Name: Pof6 interactor protein 1
• Gene Name: sip1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1919
• Subcellular Localization: Cytoplasm . Cytoplasmic vesicle . Nucleus . Golgi apparatus . Localizes to endocytotic vesicles.
• Protein Description: Required for endocytosis. Also involved in cytokinesis and cell division..
• Protein Sequence: MSLASLPLEKLTKVADVDKRETIYIDLLNYEKQLRNLNKNTREDSLQTNLNPLLSLIKKYGNFIAYPTRKLLSNCIIALLKGLEGYHQHRVLLYFVDSIHEKKDYIEIINVLSVLTSCLEEYGNQINQQETFIRFFFKYSKTNLSYGVRSIALDGLSKCIETSIQSTNEDLIKEIWKCIKSNLNTSSTNVLLSALRCAYYILGSSRLRNSELEWFKSFLFKKSSIDNSLLHSSLGRCFSALASAQADKSIEAAANAVPSTPADDENNEEVENRSTTRRFDETESFRHALRILVENYHSKHAKYESSKAVLVFAVKHLFLMQRPSFVSLNYTTIVDIILLHQSHSTSKEWLSSLEQYHCTYLFRDVIGRRFLDQSSELQGIEILLKRVLEPYLKDQSKISEIAVKTAMASTADILSRSKGSATALYSQLLDTTLQILYLGKDSLKNEVAWLLRCLLSVMPSPLMPTLLALFNRLELEFKHLRSKPKEVSPKLNVGIFNNLTLSLMSIYVAAEENPLYVASSIFSKLFNFSLDLIKSSSKLDLLAAQAQIKTGWRLLSAYVSFGPSFTRMQLSQLLILWKNALSRVPSKIHSQNFMETNADMFNRFEALQCLLSFLEYNKILFTPDVRKRVIIFLNNCLKFYKAFSLTKRLEITMPIPASDYSHLELRSLLLARIFQCFFELSQLSGMSLDDQELLSTTVSTIAELSSLQGYDTADEIVQAKAFTSPRVIPGIGSRFYAQPEEEFQTTMDDILPCYICESSSDSLSVISRSNSAKLPYVPPSLTSLIDNAIQLFASMFCHQPPKVMESTLEIMVASVTNLKSGRDILRYKAVTANTLFSIYGFLSAFDNKKVTLPDKVVSLMIELLENLTAVNDPKLIPYISKSYAFLAYLYQSKPTSVLDTIIKRAAESGDPNCRAVLILAVGHILKKVGSGVPQTTLITAYQLLKVFNTDSNDLVRECSIRASSVSLGSIAKTIPSVLTAQTRILLSYMLLPECDIDVQLLKKRNSLFFPSTLFANYLDCLINELGPNLRSDSSTSHFAFDLAHQLLLLSRDTGDNIIHVYKCYQHLYLFTPLETNSDFFIRELCGNIIDLKQPKRREISIEVLYQILLQNHEFSESCYKRHFDRLIWQSLDTTPDNKLLKNILYIWLNDYKDSDIHSWVNILLFLVGIKNTSSSERSNEQDIQNNLDEDTVSLAYGTSENASNPLFQKNYRWQTQFYAATCLKTCISEVMAENKEPAKYLISRISDLVRAAFVLSTSDNFYLKQGGFELLDTIITDFSNVMDPDFDDVSLLDQFQAQISSAFSSAFVDDSSPEIVAMSLNIASNFIGTGLLKTESQAAKILNLLKEALESSLPERAGFEENRHFKYDSKYFLRIATLSAWASLLVHSANVSYLKEFLSSNIRRLSSHWIMALRGYSRLQFGPSLVKDFVADTSFTRVQSINPKILLNIYEKSWLNIAESLTILLSTDANLIYGILSGDELSLSEEDVFFQDNINYASNRYSFNFFLFSVCFQSLLIPSTLQGFRNPVFRIMRIMTEVLTEELCTKVLYDHNVFPEVVDLLVRLILTEDWETKASIVIFVKKLALANPAHNDLKFCETDSVTSMEPTVSESVEMLFQLVKILTLALTVRVPGLRSDPAESATNKKASEFVILCFNAFLDVSNIFPAIVRVDLFATAMHVYEVIMDDQQLLKNSKQELLAALRKLLSTMVEQNDHTCTTLIYTLFEHLLNIYKETINDSDKKEKNETAFMSMVLVLTLAAPILDSEQLVVHDFLEELFSSLKSSEEDFALRTRCVTSLMLVNSKHPSMSALCRFIIYKSVTMLQNGEVLKSGDYVTEFIPALLDMHVHIPEEKKKSFLSMSIPIAAHFSILVEHADARKRIGEKLLKIMAIQPDEAKAIIQQLSPRQKKCVEEILIQNVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	NKNTREDSLQTNLNP CCCCCHHHHHHCHHH	20.02	28889911
48	Phosphorylation	TREDSLQTNLNPLLS CCHHHHHHCHHHHHH	47.14	28889911
274	Phosphorylation	NEEVENRSTTRRFDE CHHHHCHHCCCCCCH	45.79	25720772
275	Phosphorylation	EEVENRSTTRRFDET HHHHCHHCCCCCCHH	22.53	27738172
276	Phosphorylation	EVENRSTTRRFDETE HHHCHHCCCCCCHHH	22.54	29996109
1225	Phosphorylation	YAATCLKTCISEVMA HHHHHHHHHHHHHHH	11.34	29996109
1228	Phosphorylation	TCLKTCISEVMAENK HHHHHHHHHHHHHCC	26.70	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIP1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIP1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIP1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP1M1_SCHPO	apm1	genetic	23028933
AP1M1_SCHPO	apm1	physical	23028933
AP1B1_SCHPO	apl2	physical	23028933
AP1G1_SCHPO	apl4	physical	23028933
APS1_SCHPO	aps1	physical	23028933
RHO3_SCHPO	rho3	genetic	23840894
RHO3_SCHPO	rho3	physical	23840894
AP1G1_SCHPO	apl4	physical	23840894
AP1B1_SCHPO	apl2	physical	23840894
AP1M1_SCHPO	apm1	physical	23840894
APS1_SCHPO	aps1	physical	23840894

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND THR-48, AND MASSSPECTROMETRY.
PubMed: 18257517