AP1G1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP1G1_SCHPO
• UniProt AC: Q9UU81
• Protein Name: AP-1 complex subunit gamma-1
• Gene Name: apl4
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 865
• Subcellular Localization: Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex..
• Protein Description: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin (By similarity)..
• Protein Sequence: MQTTHPKNLHLTCSGVERGFTNSPKTHPKMSSLKSFIKAVRASKTTAEEHTTILKESAQIRKNIRQGSNDMRMRRKNVAKLLYLFLLGEPTHFGQIECLKLLSSSRFMDKRLGYLAAMLLLDENQEVLTLLTNSLQNDLKSRDKFIVGLALSAFGNVAGPELARDLSNDIAELCSNHHNYISKKAVLCALRVIQKEPDLESLYIEKTDELLHSKSHGVLMAALAFAISACKINPSLISRFESQADDLIYRIRQLSTSTYSSEHNIGNISDPFLQVKILQFLSILGQNNPKIYDKMSDLLAQVCTNTDSSRNAGNAILYQAVRTILDLNSDSSLRVLGVNILAKFLGNRDNNTRYVALNMLKLVVNSEENAVQRHRSTILACLNDVDSSIQSRALELSTFLVNEANVRFMVRELLSFLDNVSDELRGSTAQYITEVTNAFAPNKRWHFDTLLRVFKSAGNFVSESTLSTFLRLIASAPELHEYAVVKLYAALKEDVSQEALTLSAFWVIGEYGQMLLSPTMNFDDDQTLPHSVSESDIVDIIEEVFNSVEASRYIIVQYGLFALTKLSARLGSSSTASRIDKIIYSYKRNKNTEVQQRSVEFHLILNDSKLSKTILEPTPAPLPPPRTTPYQNAEQKLKANKHVEKRVQESNELLDLIGLTTPSVAEPLETPVDEMTQSPQSSLSRAPSTSKKSHFEDILGLFASPAPSAQPVDSLASSFASLDFNASASQPSNNLSLLSSIPSTSKSYPPIVVFDKHDVTLTLVPSKEESTKTAVIEAKFKNKNPMTRVEKIHLEVAVPKSQKLKIQPLRTTSMEPGGETSQTLRVHGPSGSQVKLRLRISVVRQGGSNTLDQVDFGKLPSDLLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
670	Phosphorylation	SVAEPLETPVDEMTQ CCCCCCCCCHHHHCC	35.97	29996109
676	Phosphorylation	ETPVDEMTQSPQSSL CCCHHHHCCCCCHHH	24.69	21712547
678	Phosphorylation	PVDEMTQSPQSSLSR CHHHHCCCCCHHHCC	18.75	21712547
681	Phosphorylation	EMTQSPQSSLSRAPS HHCCCCCHHHCCCCC	36.31	21712547
682	Phosphorylation	MTQSPQSSLSRAPST HCCCCCHHHCCCCCC	25.72	29996109
684	Phosphorylation	QSPQSSLSRAPSTSK CCCCHHHCCCCCCCC	28.48	21712547
688	Phosphorylation	SSLSRAPSTSKKSHF HHHCCCCCCCCCCCH	44.31	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AP1G1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP1G1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP1G1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MOD21_SCHPO	mod21	physical	17021256
RHO3_SCHPO	rho3	genetic	21304827
RHO3_SCHPO	rho3	physical	21304827

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.