SIAT6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIAT6_HUMAN
• UniProt AC: Q11203
• Protein Name: CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
• Gene Name: ST3GAL3
• Organism: Homo sapiens (Human).
• Sequence Length: 375
• Subcellular Localization: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
• Protein Description: Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc..
• Protein Sequence: MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEEDSNSVVLSFDSAGQTLGSEYDRLGFLLNLDSKLPAELATKYANFSEGACKPGYASALMTAIFPRFSKPAPMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSSGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	O-linked_Glycosylation	SFDSAGQTLGSEYDR EECCCCCCCCCCHHH	31.97	OGP
61 (in isoform 26)	Phosphorylation	-	16.43	28387310
74 (in isoform 22)	Phosphorylation	-	8.78	30206219
76 (in isoform 22)	Phosphorylation	-	36.89	30206219
80	N-linked_Glycosylation	ELATKYANFSEGACK HHHHHHCCCCCCCCC	37.58	UniProtKB CARBOHYD
80 (in isoform 22)	Phosphorylation	-	37.58	30206219
103	Phosphorylation	TAIFPRFSKPAPMFL HHHCCCCCCCCCCCC	38.72	22210691
154	Phosphorylation	RLTPALDSLRCRRCI CCCHHHHHCCCCEEE	20.68	-
171	N-linked_Glycosylation	GNGGVLANKSLGSRI CCCCEECCCCCCCCC	30.23	UniProtKB CARBOHYD
173	Phosphorylation	GGVLANKSLGSRIDD CCEECCCCCCCCCCC	37.46	22496350
202	Ubiquitination	FEKDVGSKTTLRITY EECCCCCCEEEEEEC	39.33	-
220	Phosphorylation	AMQRPEQYERDSLFV CCCCHHHHCCCCEEE	15.98	-
241	Phosphorylation	QDFKWLKYIVYKERV HCCCCEEEEEEEECC	8.08	-
244	Phosphorylation	KWLKYIVYKERVSAS CCEEEEEEEECCCCC	9.51	-
257	Phosphorylation	ASDGFWKSVATRVPK CCCCCHHHHHHCCCC	13.95	27251275
260	Phosphorylation	GFWKSVATRVPKEPP CCHHHHHHCCCCCCC	30.00	27251275
328	O-linked_Glycosylation	GFGYDMSTPNAPLHY CCCCCCCCCCCCCCH	17.58	OGP
329	Phosphorylation	FGYDMSTPNAPLHYY CCCCCCCCCCCCCHH	27.90	27251275
369	Phosphorylation	LVKARVITDLSSGI- HHHHHHHHHHCCCC-	28.20	19664994
373	Phosphorylation	RVITDLSSGI----- HHHHHHCCCC-----	48.05	19664994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIAT6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIAT6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIAT6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTG_HUMAN	ACTG1	physical	16169070
SCAM2_HUMAN	SCAMP2	physical	16169070
ZBTB5_HUMAN	ZBTB5	physical	16169070
RL8_HUMAN	RPL8	physical	16169070

Drug and Disease Associations

• Kegg Disease
• H00768: Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
• OMIM Disease
• 611090: Mental retardation, autosomal recessive 12 (MRT12)
• 615006: Epileptic encephalopathy, early infantile, 15 (EIEE15)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.