SERC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SERC3_HUMAN
• UniProt AC: Q13530
• Protein Name: Serine incorporator 3
• Gene Name: SERINC3
• Organism: Homo sapiens (Human).
• Sequence Length: 473
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .; Cytoplasm, perinuclear region . (Microbial infection) Upon HIV-1 infection, it is redirected to perinuclear region following interaction with HIV-
• Protein Description: Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. [PubMed: 26416733]
• Protein Sequence: MGAVLGVFSLASWVPCLCSGASCLLCSCCPNSKNSTVTRLIYAFILLLSTVVSYIMQRKEMETYLKKIPGFCEGGFKIHEADINADKDCDVLVGYKAVYRISFAMAIFFFVFSLLMFKVKTSKDLRAAVHNGFWFFKIAALIGIMVGSFYIPGGYFSSVWFVVGMIGAALFILIQLVLLVDFAHSWNESWVNRMEEGNPRLWYAALLSFTSAFYILSIICVGLLYTYYTKPDGCTENKFFISINLILCVVASIISIHPKIQEHQPRSGLLQSSLITLYTMYLTWSAMSNEPDRSCNPNLMSFITRITAPTLAPGNSTAVVPTPTPPSKSGSLLDSDNFIGLFVFVLCLLYSSIRTSTNSQVDKLTLSGSDSVILGDTTTSGASDEEDGQPRRAVDNEKEGVQYSYSLFHLMLCLASLYIMMTLTSWYSPDAKFQSMTSKWPAVWVKISSSWVCLLLYVWTLVAPLVLTSRDFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	VLGVFSLASWVPCLC HHHHHHHHHHHHHHH	10.51	27667366
12	Ubiquitination	LGVFSLASWVPCLCS HHHHHHHHHHHHHHC	33.62	-
34	N-linked_Glycosylation	SCCPNSKNSTVTRLI HCCCCCCCHHHHHHH	42.61	UniProtKB CARBOHYD
42	Phosphorylation	STVTRLIYAFILLLS HHHHHHHHHHHHHHH	10.47	25404012
49	Phosphorylation	YAFILLLSTVVSYIM HHHHHHHHHHHHHHH	21.08	25404012
50	Phosphorylation	AFILLLSTVVSYIMQ HHHHHHHHHHHHHHH	25.54	25404012
53	Phosphorylation	LLLSTVVSYIMQRKE HHHHHHHHHHHHHHH	12.47	25404012
54	Phosphorylation	LLSTVVSYIMQRKEM HHHHHHHHHHHHHHH	6.71	25404012
63	Phosphorylation	MQRKEMETYLKKIPG HHHHHHHHHHHHCCC	32.61	25404012
64	Phosphorylation	QRKEMETYLKKIPGF HHHHHHHHHHHCCCC	11.83	25404012
66	Ubiquitination	KEMETYLKKIPGFCE HHHHHHHHHCCCCCC	37.94	27667366
67	Ubiquitination	EMETYLKKIPGFCEG HHHHHHHHCCCCCCC	52.09	29967540
72	S-palmitoylation	LKKIPGFCEGGFKIH HHHCCCCCCCCEEEE	6.18	29575903
77	Ubiquitination	GFCEGGFKIHEADIN CCCCCCEEEECCCCC	46.56	29967540
87	Ubiquitination	EADINADKDCDVLVG CCCCCCCCCCCEECC	58.82	29967540
294	Phosphorylation	MSNEPDRSCNPNLMS HCCCCCCCCCCCHHH	26.15	-
295	S-palmitoylation	SNEPDRSCNPNLMSF CCCCCCCCCCCHHHH	11.62	29575903
310	Phosphorylation	ITRITAPTLAPGNST HHHHCCCCCCCCCCC	32.84	-
317	O-linked_Glycosylation	TLAPGNSTAVVPTPT CCCCCCCCEEECCCC	27.72	OGP
322	Phosphorylation	NSTAVVPTPTPPSKS CCCEEECCCCCCCCC	28.34	25332170
322	O-linked_Glycosylation	NSTAVVPTPTPPSKS CCCEEECCCCCCCCC	28.34	OGP
327	Phosphorylation	VPTPTPPSKSGSLLD ECCCCCCCCCCCCCC	40.43	25332170
355	Phosphorylation	LLYSSIRTSTNSQVD HHHHHHHCCCCCCCC	37.93	-
356	Phosphorylation	LYSSIRTSTNSQVDK HHHHHHCCCCCCCCE	18.75	-
357	Phosphorylation	YSSIRTSTNSQVDKL HHHHHCCCCCCCCEE	37.97	25954137
363	Ubiquitination	STNSQVDKLTLSGSD CCCCCCCEEEECCCC	44.51	33845483
365	Phosphorylation	NSQVDKLTLSGSDSV CCCCCEEEECCCCEE	25.31	25849741
367	Phosphorylation	QVDKLTLSGSDSVIL CCCEEEECCCCEEEE	30.89	29743597
369	Phosphorylation	DKLTLSGSDSVILGD CEEEECCCCEEEECC	24.28	25159151
371	Phosphorylation	LTLSGSDSVILGDTT EEECCCCEEEECCCC	16.86	29743597
377	Phosphorylation	DSVILGDTTTSGASD CEEEECCCCCCCCCC	30.12	30624053
378	Phosphorylation	SVILGDTTTSGASDE EEEECCCCCCCCCCC	24.57	30624053
379	Phosphorylation	VILGDTTTSGASDEE EEECCCCCCCCCCCC	27.53	30624053
380	Phosphorylation	ILGDTTTSGASDEED EECCCCCCCCCCCCC	30.21	27251275
383	Phosphorylation	DTTTSGASDEEDGQP CCCCCCCCCCCCCCC	49.43	25954137

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
380	S	Phosphorylation	Kinase	CK2A1	P68400	PSP
383	S	Phosphorylation	Kinase	CK2A1	P68400	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SERC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SERC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XPO5_HUMAN	XPO5	physical	17353931
PHB2_HUMAN	PHB2	physical	17353931
SURF4_HUMAN	SURF4	physical	17353931
VDAC2_HUMAN	VDAC2	physical	17353931
ERD21_HUMAN	KDELR1	physical	17353931
HACD3_HUMAN	PTPLAD1	physical	17353931
MOT1_HUMAN	SLC16A1	physical	17353931
ERD22_HUMAN	KDELR2	physical	17353931

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.