dbPTM

RYR2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RYR2_MOUSE
UniProt AC	E9Q401
Protein Name	Ryanodine receptor 2
Gene Name	Ryr2
Organism	Mus musculus (Mouse).
Sequence Length	4966
Subcellular Localization	Sarcoplasmic reticulum membrane Multi-pass membrane protein . Membrane Multi-pass membrane protein . Sarcoplasmic reticulum . The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cy
Protein Description	Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development..
Protein Sequence	MADAGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNSSWHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFAFRSSKEKLDVGVRKEVDGMGTSEIKYGDSICYIQHVDTGLWLTYQAVDVKSARMGSIQRKAIMHHEGHMDDGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKVKLPTIDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAACYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPVPVDTSQIVLPPHLERIRERLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYHLEAPDQDHASRAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDLELGSDDRAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNNNTDIMFYRLSMPIECAEVFSKSVAGGLPGAGFYGPKNDLEDFDVDSDFEVLMKTAHGHLVPDRIDKDKETPKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTGHSARLTEDVLADDRDDYEYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGRNNSNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLQFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMRFSSPSFVSISNDCYQYSPEFPLDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAAVPEEEGGTPEKEISIEDAKLEGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTREFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGSNDLTIRGRLLSLVEKVTYLKKKQAEKPVASDSRKCSSLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLDIEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGKVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKIQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSIDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDIFKFLQISGYVVSRGFKDLDLDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCTGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRSQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPIAFLETHLDKHNVYSIYNTRSSRERAALSLPANVEDVCPNIPSLEKLMTEIIELAESGIRYTQMPYMMEVVLPMLCSYMSRWWEHGPENHPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAISDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEEEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTEDPSDPERTVERVLGIANVLFHLEQKSKYTGRGYFSLVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAELPEEDEAMKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDIIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERLANKEESEKERPEEQAPRMGFFSLLTIQSALFALRYNVLTLVRMLSLKSLKKQMKRMKKMTVKDMVLAFFSSYWSVFVTLLHFVASVCRGFFRIVSSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDEEEGERKPLESALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMTNPVPVPEVQEKFQEQKAKEEKEEKEETKSEPEKAEGEDGEKEEKAKDEKSKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRTSSDTAKVTNSLDSSPHRIIAVHYVLEESSGYMEPTLRILAILHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Glutathionylation	HKEQQKLCLAAEGFG CHHHHHHHHHCCCCC	2.90	22833525
170	Phosphorylation	HPASKQRSEGEKVRV CCCCCCCCCCCCEEE	47.67	-
285	Phosphorylation	ETLRVAWSGSHIRWG EEEEEEECCCCCCCC	22.23	28285833
287	Phosphorylation	LRVAWSGSHIRWGQP EEEEECCCCCCCCCC	15.38	28285833
304	Ubiquitination	LRHVTTGKYLSLMED EEECCCCCCHHHHCC	40.71	22790023
335	Acetylation	AFAFRSSKEKLDVGV HHHCCCCHHHCCCCC	61.18	19866005
337	Acetylation	AFRSSKEKLDVGVRK HCCCCHHHCCCCCCC	54.44	19866015
653	Phosphorylation	TRLVNHVSSMRPNIF HHHHHHHHCCCCCEE	15.74	24759943
654	Phosphorylation	RLVNHVSSMRPNIFL HHHHHHHCCCCCEEE	20.09	24759943
664	Phosphorylation	PNIFLGVSEGSAQYK CCEEEEECCCCHHHH	34.15	24759943
667	Phosphorylation	FLGVSEGSAQYKKWY EEEECCCCHHHHHHH	14.24	24759943
670	Phosphorylation	VSEGSAQYKKWYYEL ECCCCHHHHHHHHHH	17.79	24759943
706	Phosphorylation	STEGYSPYPGGGEEW CCCCCCCCCCCCCCC	14.47	-
767	Phosphorylation	DLSAPSISFRINGQP CCCCCEEEEEECCEE	16.89	28973931
819	Phosphorylation	KFLPPPGYAACYEAV EECCCCCCHHHHHHH	9.22	-
822	Glutathionylation	PPPGYAACYEAVLPK CCCCCHHHHHHHCCH	2.10	22833525
823	Phosphorylation	PPGYAACYEAVLPKE CCCCHHHHHHHCCHH	11.38	-
917	Glutathionylation	DNKRQHPCLVEFCKL CCCCCCCCEEEECCC	6.62	22833525
998	Acetylation	SQEAMVDKLAENAHN CHHHHHHHHHHCCCC	55.58	19845151
1141	Acetylation	AFAFDGFKAQRWHQG EEECCCCCEEECCCC	49.49	7923721
1223	Phosphorylation	NFGKDVSTLKYFTIC CCCCCCCCCCEEEEC	27.41	21659604
1248	Phosphorylation	VNTNRDITMWLSKRL CCCCCHHHHHHHHCC	13.44	28464351
1253	Ubiquitination	DITMWLSKRLPQFLQ HHHHHHHHCCHHHCC	56.64	22790023
1284	Ubiquitination	IDSSPCLKVTQKSFG ECCCCCEEEEHHHHC	50.37	22790023
1288	Ubiquitination	PCLKVTQKSFGSQNN CCEEEEHHHHCCCCC	38.08	22790023
1317	Phosphorylation	CAEVFSKSVAGGLPG HHHHHCHHHCCCCCC	18.92	27742792
1341	Phosphorylation	LEDFDVDSDFEVLMK HHHCCCCCCHHHHHH	44.01	23737553
1398	Phosphorylation	RRTKPDYSTGHSARL HCCCCCCCCCCCCCC	34.98	27742792
1399	Phosphorylation	RTKPDYSTGHSARLT CCCCCCCCCCCCCCC	32.46	27742792
1402	Phosphorylation	PDYSTGHSARLTEDV CCCCCCCCCCCCCCH	19.21	27742792
1464	Phosphorylation	FDLDRVRTVTVTLGD CCCCCEEEEEEEECC	20.06	28576409
1466	Phosphorylation	LDRVRTVTVTLGDEK CCCEEEEEEEECCCC	13.73	28576409
1468	Phosphorylation	RVRTVTVTLGDEKGK CEEEEEEEECCCCCC	18.69	28576409
1473	Ubiquitination	TVTLGDEKGKVHESI EEEECCCCCCCCCHH	69.63	22790023
1483	Phosphorylation	VHESIKRSNCYMVCA CCCHHHCCCCEEEEC	26.67	20415495
1486	Phosphorylation	SIKRSNCYMVCAGES HHHCCCCEEEECCCC	9.24	20415495
1493	Phosphorylation	YMVCAGESMSPGQGR EEEECCCCCCCCCCC	24.52	25521595
1495	Phosphorylation	VCAGESMSPGQGRNN EECCCCCCCCCCCCC	34.85	25521595
1562	Ubiquitination	QFELGRIKNVMPLSA EEEECCCCCCEECCC	41.97	22790023
1583	Glutathionylation	HKNPVPQCPPRLHVQ CCCCCCCCCCHHHHH	4.02	22833525
1791	Ubiquitination	PLDILKAKTIQMLTE CHHHHHHHHHHHHHH	44.57	22790023
1801	Ubiquitination	QMLTEAVKEGSLHAR HHHHHHHHHCCCCCC	64.50	22790023
1864	Phosphorylation	VPEEEGGTPEKEISI CCHHHCCCCCCEEEH	38.85	25521595
1867	Ubiquitination	EEGGTPEKEISIEDA HHCCCCCCEEEHHHH	62.64	22790023
1870	Phosphorylation	GTPEKEISIEDAKLE CCCCCEEEHHHHHHC	22.48	23737553
1875	Ubiquitination	EISIEDAKLEGEEEA EEEHHHHHHCCHHHH	60.43	22790023
2030	Phosphorylation	TIRGRLLSLVEKVTY CHHHHHHHHHHHHHH	34.65	23737553
2034	Ubiquitination	RLLSLVEKVTYLKKK HHHHHHHHHHHHHHH	32.19	22790023
2152	Ubiquitination	LGDIMNNKVFYQHPN HHHHHCCCHHHCCCC	28.81	22790023
2271	S-palmitoylation	VVRYLAGCGLQSCQM HHHHHHHCCHHHHHH	4.01	28680068
2329	Glutathionylation	LLIRRPECFGPALRG HHHCCHHHCCHHHCC	5.46	22833525
2357	Phosphorylation	IKIAEDPSRDGPSPT HHHCCCCCCCCCCCC	56.15	22324799
2362	Phosphorylation	DPSRDGPSPTSGSSK CCCCCCCCCCCCCCC	46.47	25521595
2364	Phosphorylation	SRDGPSPTSGSSKTL CCCCCCCCCCCCCCC	50.48	25521595
2365	Phosphorylation	RDGPSPTSGSSKTLD CCCCCCCCCCCCCCC	39.81	23737553
2367	Phosphorylation	GPSPTSGSSKTLDIE CCCCCCCCCCCCCCC	28.55	22324799
2368	Phosphorylation	PSPTSGSSKTLDIEE CCCCCCCCCCCCCCC	32.93	22324799
2420	Phosphorylation	GEAIRIRSILRSLIP CHHHHHHHHHHHHCC	24.49	30387612
2449	Ubiquitination	PTIAKDGKVVEPDMS CCEECCCCEECCCCC	53.92	22790023
2607	Ubiquitination	EHAKMPLKLLTNHYE HHHCCCHHHHHHHHH	35.26	22790023
2655	Ubiquitination	FDALSQKKYEQELFK HHHHCCHHHHHHHHH	46.51	22790023
2692	Phosphorylation	VSMMEKQSSMDSEGN HHHHHHCCCCCCCCC	38.40	25521595
2693	Phosphorylation	SMMEKQSSMDSEGNF HHHHHCCCCCCCCCC	24.90	25521595
2696	Phosphorylation	EKQSSMDSEGNFNPQ HHCCCCCCCCCCCCC	38.47	25521595
2707	Phosphorylation	FNPQPVDTSNITIPE CCCCCCCCCCCCCCH	24.73	30165576
2708	Phosphorylation	NPQPVDTSNITIPEK CCCCCCCCCCCCCHH	23.05	30165576
2711	Phosphorylation	PVDTSNITIPEKLEY CCCCCCCCCCHHHHH	34.43	30165576
2718	Phosphorylation	TIPEKLEYFINKYAE CCCHHHHHHHHHHHC	21.86	20415495
2796	Phosphorylation	ERTREGDSMALYNRT EECCCCCCCCEEECC	19.46	19060867
2807	Phosphorylation	YNRTRRISQTSQVSI EECCCCCCCCCCCCH	26.12	20479242
2809	Phosphorylation	RTRRISQTSQVSIDA CCCCCCCCCCCCHHH	17.84	22324799
2810	Phosphorylation	TRRISQTSQVSIDAA CCCCCCCCCCCHHHC	22.43	22324799
2813	Phosphorylation	ISQTSQVSIDAAHGY CCCCCCCCHHHCCCC	13.71	20479242
2820	Phosphorylation	SIDAAHGYSPRAIDM CHHHCCCCCCCCCCC	12.97	27742792
2821	Phosphorylation	IDAAHGYSPRAIDMS HHHCCCCCCCCCCCC	16.71	27742792
2862	Ubiquitination	KKLELESKGGGNHPL CCEEEECCCCCCCCE	52.80	22790023
2879	Ubiquitination	PYDTLTAKEKAKDRE CCCCCCHHHHHCHHH	55.29	22790023
2898	Phosphorylation	IFKFLQISGYVVSRG HHHHHHHHCCHHHCC	15.88	-
2900	Phosphorylation	KFLQISGYVVSRGFK HHHHHHCCHHHCCCC	7.29	-
2907	Ubiquitination	YVVSRGFKDLDLDTP CHHHCCCCCCCCCCC	61.27	22790023
2915	Phosphorylation	DLDLDTPSIEKRFAY CCCCCCCCHHHHHHH	45.53	27742792
2946	Phosphorylation	ILEFDGGSRSKGEHF EEEECCCCCCCCCCC	38.62	21098440
3075	Ubiquitination	EKTMENLKQGQFTHT HHHHHHHHCCCCCCC	65.06	22790023
3157	Glutathionylation	QRSALGECLAAFAGA HHHHHHHHHHHHHCC	2.73	22833525
3204	S-palmitoylation	PANVEDVCPNIPSLE CCCHHHHCCCCCCHH	3.10	28680068
3227	Phosphorylation	LAESGIRYTQMPYMM HHHCCCCCCCCCHHH	10.21	-
3232	Phosphorylation	IRYTQMPYMMEVVLP CCCCCCCHHHHHHHH	12.07	-
3244	Phosphorylation	VLPMLCSYMSRWWEH HHHHHHHHHHHHHHH	9.71	-
3296	Ubiquitination	IDEGAWMKRLAVFSQ CCCCHHHHHHHHHCH	33.29	22790023
3324	Ubiquitination	HFLPLMEKLKKKAAM CCHHHHHHHHHHHCE	52.20	22790023
3328	Ubiquitination	LMEKLKKKAAMVVSE HHHHHHHHHCEEECH	39.53	22790023
3437	Methylation	LITDTKSKMSKAAIS EEEECCHHHHHHHCC	49.07	-
3440	Methylation	DTKSKMSKAAISDQE ECCHHHHHHHCCHHH	38.04	-
3531	Ubiquitination	RWQMALYKDLPNRTE HHHHHHHCCCCCCCC	54.35	22790023
3573	Phosphorylation	YTGRGYFSLVEHPQR CCCCCCCHHCCCHHH	24.03	19060867
3601	Glutathionylation	RKRAVVACFRMAPLY HHHHHHHHHHCCHHH	1.18	22833525
3876	Phosphorylation	IIISTVDYLLRVQES EEEECHHHHHHHHHH	11.87	28576409
3958	Phosphorylation	AHMQMKLSQDSSQIE HHHHHHHCCCHHHHH	26.82	29899451
3961	Phosphorylation	QMKLSQDSSQIELLK HHHHCCCHHHHHHHH	19.26	29899451
4053	Phosphorylation	DFHKAMESHKHYTQS HHHHHHHHCCCCCHH	25.42	21183079
4359	Phosphorylation	PLESALPSEDLTDLK CHHHCCCCCCCCCHH	44.59	23882026
4384	Acetylation	DIFGLDLKREGGQYK HHHCCCEEECCCCEE	48.33	23864654
4390	Phosphorylation	LKREGGQYKLIPHNP EEECCCCEEECCCCC	15.84	23140645
4391	Ubiquitination	KREGGQYKLIPHNPN EECCCCEEECCCCCC	31.86	22790023
4433	Phosphorylation	EKEEKEETKSEPEKA HHHHHHHHCCCCCCC	40.75	23737553
4435	Phosphorylation	EEKEETKSEPEKAEG HHHHHHCCCCCCCCC	66.84	23737553
4558	Phosphorylation	HRIIAVHYVLEESSG CEEEEEEEEHHCCCC	10.51	21454597
4563	Phosphorylation	VHYVLEESSGYMEPT EEEEHHCCCCCCHHH	21.49	21454597
4564	Phosphorylation	HYVLEESSGYMEPTL EEEHHCCCCCCHHHH	36.90	21454597
4570	Phosphorylation	SSGYMEPTLRILAIL CCCCCHHHHHHHHHH	18.50	21454597
4666	Phosphorylation	FYGRDRISELLGMDK HHCHHHHHHHHCCCH	24.08	26239621

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
2030	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
2030	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
2030	S	Phosphorylation	Kinase	PKA	-	Uniprot
2807	S	Phosphorylation	Kinase	PKACA	P17612	PSP
2807	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
2807	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
2807	S	Phosphorylation	Kinase	CAMK2D	Q6PHZ2	Uniprot
2807	S	Phosphorylation	Kinase	PRKG1	Q13976	GPS
2807	S	Phosphorylation	Kinase	PKA	-	Uniprot
2813	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
2813	S	Phosphorylation	Kinase	CAMK2A	P11798	PSP
2813	S	Phosphorylation	Kinase	CAMK2D	Q13557	PSP
2813	S	Phosphorylation	Kinase	CAMK2D	Q6PHZ2	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
2030	S	Phosphorylation	17693412
Phosphorylation at Ser-2030 by PKA enhances the response to lumenal calcium.
2807	S	Phosphorylation	21183079
Phosphorylation at Ser-2807 and Ser-2813 increases the open probability of the calcium channel.
2813	S	Phosphorylation	21183079
Phosphorylation at Ser-2807 and Ser-2813 increases the open probability of the calcium channel.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RYR2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SORCN_MOUSE	Sri	physical	16204356
PSN2_MOUSE	Psen2	physical	16204356
FKB1B_MOUSE	Fkbp1b	physical	16481613

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RYR2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilizedcardiac myocytes and effects on Ca sparks."; Guo T., Cornea R.L., Huke S., Camors E., Yang Y., Picht E.,Fruen B.R., Bers D.M.; Circ. Res. 106:1743-1752(2010). Cited for: FUNCTION, INTERACTION WITH FKBP1A AND FKBP1B, AND PHOSPHORYLATION ATSER-2807.	20431056 [Abstract]
"Ryanodine receptor phosphorylation by calcium/calmodulin-dependentprotein kinase II promotes life-threatening ventricular arrhythmias inmice with heart failure."; van Oort R.J., McCauley M.D., Dixit S.S., Pereira L., Yang Y.,Respress J.L., Wang Q., De Almeida A.C., Skapura D.G., Anderson M.E.,Bers D.M., Wehrens X.H.; Circulation 122:2669-2679(2010). Cited for: FUNCTION, PHOSPHORYLATION AT SER-2807 AND SER-2813, INTERACTION WITHFKBP1B, AND MUTAGENESIS OF SER-2813.	21098440 [Abstract]

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