RPH3L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPH3L_HUMAN
• UniProt AC: Q9UNE2
• Protein Name: Rab effector Noc2
• Gene Name: RPH3AL
• Organism: Homo sapiens (Human).
• Sequence Length: 315
• Subcellular Localization: Cytoplasm . Cytoplasmic vesicle, secretory vesicle membrane . Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells.
• Protein Description: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells..
• Protein Sequence: MADTIFGSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRKQHLSPAEVEAILQVIQRAERLDVLEQQRIGRLVERLETMRRNVMGNGLSQCLLCGEVLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPLPTEPAEREPRSSETSRIYTWARGRVVSSDSDSDSDLSSSSLEDRLPSTGVRDRKGDKPWKESGGSVEAPRMGFTHPPGHLSGCQSSLASGETGTGSADPPGGPRPGLTRRAPVKDTPGRAPAADAAPAGPSSCLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MADTIFGSGND ----CCCCCCCCCCC	14.52	24043423
8	Phosphorylation	MADTIFGSGNDQWVC CCCCCCCCCCCCEEC	24.55	24043423
128	Phosphorylation	TKCGIEASPGQKRPL HHCCCCCCCCCCCCC	19.44	27251275
142	Phosphorylation	LWLCKICSEQREVWK CHHHHHCHHHHHHHH	39.99	23403867
168	Phosphorylation	KYILPLKTPGRADDP EEEEECCCCCCCCCC	38.36	26657352
210	Phosphorylation	GRVVSSDSDSDSDLS CCEECCCCCCCCCCC	40.75	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPH3L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPH3L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPH3L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UN13B_HUMAN	UNC13B	physical	14593078
TCEA3_HUMAN	TCEA3	physical	21988832
TRIM1_HUMAN	MID2	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.