TCEA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCEA3_HUMAN
• UniProt AC: O75764
• Protein Name: Transcription elongation factor A protein 3
• Gene Name: TCEA3
• Organism: Homo sapiens (Human).
• Sequence Length: 348
• Subcellular Localization: Nucleus .
• Protein Description: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus..
• Protein Sequence: MGQEEELLRIAKKLEKMVARKNTEGALDLLKKLHSCQMSIQLLQTTRIGVAVNGVRKHCSDKEVVSLAKVLIKNWKRLLDSPGPPKGEKGEEREKAKKKEKGLECSDWKPEAGLSPPRKKREDPKTRRDSVDSKSSASSSPKRPSVERSNSSKSKAESPKTPSSPLTPTFASSMCLLAPCYLTGDSVRDKCVEMLSAALKADDDYKDYGVNCDKMASEIEDHIYQELKSTDMKYRNRVRSRISNLKDPRNPGLRRNVLSGAISAGLIAKMTAEEMASDELRELRNAMTQEAIREHQMAKTGGTTTDLFQCSKCKKKNCTYNQVQTRSADEPMTTFVLCNECGNRWKFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Phosphorylation	NWKRLLDSPGPPKGE HHHHHHCCCCCCCCC	31.55	28985074
106	Phosphorylation	KEKGLECSDWKPEAG HHCCCCCCCCCCCCC	36.81	23312004
115	Phosphorylation	WKPEAGLSPPRKKRE CCCCCCCCCCCCCCC	31.76	23401153
126	Phosphorylation	KKREDPKTRRDSVDS CCCCCCCCCHHHCCC	36.00	28102081
130	Phosphorylation	DPKTRRDSVDSKSSA CCCCCHHHCCCCCCC	26.47	26699800
133	Phosphorylation	TRRDSVDSKSSASSS CCHHHCCCCCCCCCC	32.08	28985074
134	Ubiquitination	RRDSVDSKSSASSSP CHHHCCCCCCCCCCC	43.92	-
135	Phosphorylation	RDSVDSKSSASSSPK HHHCCCCCCCCCCCC	34.78	23403867
136	Phosphorylation	DSVDSKSSASSSPKR HHCCCCCCCCCCCCC	35.59	23403867
138	Phosphorylation	VDSKSSASSSPKRPS CCCCCCCCCCCCCCC	33.04	23403867
139	Phosphorylation	DSKSSASSSPKRPSV CCCCCCCCCCCCCCC	50.83	23401153
140	Phosphorylation	SKSSASSSPKRPSVE CCCCCCCCCCCCCCC	31.76	30278072
145	Phosphorylation	SSSPKRPSVERSNSS CCCCCCCCCCCCCCC	40.41	23401153
154	Phosphorylation	ERSNSSKSKAESPKT CCCCCCCCCCCCCCC	38.76	28857561
158	Phosphorylation	SSKSKAESPKTPSSP CCCCCCCCCCCCCCC	36.23	29116813
161	Phosphorylation	SKAESPKTPSSPLTP CCCCCCCCCCCCCCH	31.61	29116813
163	Phosphorylation	AESPKTPSSPLTPTF CCCCCCCCCCCCHHH	50.23	29116813
164	Phosphorylation	ESPKTPSSPLTPTFA CCCCCCCCCCCHHHH	25.73	29116813
167	Phosphorylation	KTPSSPLTPTFASSM CCCCCCCCHHHHHHH	24.54	29116813
169	Phosphorylation	PSSPLTPTFASSMCL CCCCCCHHHHHHHHH	26.97	29116813
172	Phosphorylation	PLTPTFASSMCLLAP CCCHHHHHHHHHHHH	17.89	29116813
173	Phosphorylation	LTPTFASSMCLLAPC CCHHHHHHHHHHHHH	15.30	27251275
181	Phosphorylation	MCLLAPCYLTGDSVR HHHHHHHHHHCHHHH	13.26	23090842
183	Phosphorylation	LLAPCYLTGDSVRDK HHHHHHHHCHHHHHH	16.68	23090842
186	Phosphorylation	PCYLTGDSVRDKCVE HHHHHCHHHHHHHHH	22.01	23090842
243	Phosphorylation	NRVRSRISNLKDPRN HHHHHHHHCCCCCCC	34.69	28787133
263	Phosphorylation	NVLSGAISAGLIAKM HHHHHHHHHHHHHHH	18.75	22210691
271	Phosphorylation	AGLIAKMTAEEMASD HHHHHHHCHHHHCHH	30.15	24043423
311	Phosphorylation	TTDLFQCSKCKKKNC CCCHHHCCCCCCCCC	30.24	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCEA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCEA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCEA3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TCEA3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.