RN115_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RN115_MOUSE
• UniProt AC: Q9D0C1
• Protein Name: E3 ubiquitin-protein ligase RNF115 {ECO:0000305}
• Gene Name: Rnf115 {ECO:0000312|MGI:MGI:1915095}
• Organism: Mus musculus (Mouse).
• Sequence Length: 305
• Subcellular Localization: Cytoplasm, cytosol . The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes.
• Protein Description: E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4..
• Protein Sequence: MAEASAAGADAGSAVAAHRFFCHFCKGEVNPKLPEYICPRCDSGFIEEVTDDSSFLGGGGSRTDNSTATHFAELWDHLDHTMFLQDFRPFLSSNPLDQDNRANERGHQTHTDFWGPSRPPRLPMTRRYRSRGSTRPDRSPAIEGIIQQIFAGFFANSAIPGSPHPFSWSGMLHSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVNTGLECPVCKEDYTVEEKVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQTQSSEASASNRFSNDSQLHDRWTF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEASAAGA ------CCCHHHHCC	22.51	-
26	Ubiquitination	RFFCHFCKGEVNPKL HHHHHHHCCCCCCCC	58.10	-
32	Ubiquitination	CKGEVNPKLPEYICP HCCCCCCCCCHHHCC	72.04	-
202	Ubiquitination	GQLENTGPPPADKEK HHHHHCCCCCCCHHH	29.66	27667366
241	Ubiquitination	EDYTVEEKVRQLPCN CCCCHHHHHHCCCCC	29.25	27667366
304	Phosphorylation	SQLHDRWTF------ CCCCCCCCC------	21.99	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RN115_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RN115_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RN115_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBE2H_HUMAN	UBE2H	physical	17462600
UB2D2_HUMAN	UBE2D2	physical	17462600
UB2D3_HUMAN	UBE2D3	physical	17462600
UB2E1_HUMAN	UBE2E1	physical	17462600
UBC_MOUSE	Ubc	physical	17462600
RN115_MOUSE	Rnf115	physical	17462600

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.