dbPTM

RGS16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RGS16_HUMAN
UniProt AC	O15492
Protein Name	Regulator of G-protein signaling 16
Gene Name	RGS16
Organism	Homo sapiens (Human).
Sequence Length	202
Subcellular Localization	Membrane Lipid-anchor .
Protein Description	Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. [PubMed: 11602604]
Protein Sequence	MCRTLAAFPTTCLERAKEFKTRLGIFLHKSELGCDTGSTGKFEWGSKHSKENRNFSEDVLGWRESFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSATKLASRAHQIFEEFICSEAPKEVNIDHETHELTRMNLQTATATCFDAAQGKTRTLMEKDSYPRFLKSPAYRDLAAQASAASATLSSCSLDEPSHT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	S-palmitoylation	------MCRTLAAFP ------CCCCCCCCC	4.59	14642772
10	Phosphorylation	RTLAAFPTTCLERAK CCCCCCCHHHHHHHH	24.56	30631047
11	Phosphorylation	TLAAFPTTCLERAKE CCCCCCHHHHHHHHH	18.48	30631047
12	S-palmitoylation	LAAFPTTCLERAKEF CCCCCHHHHHHHHHH	4.01	14642772
41	Ubiquitination	CDTGSTGKFEWGSKH CCCCCCCCCCCCCCC	39.95	29967540
71	Phosphorylation	ESFDLLLSSKNGVAA HHHHHHHHCCCCHHH	38.96	-
72	Phosphorylation	SFDLLLSSKNGVAAF HHHHHHHCCCCHHHH	30.06	-
73	Acetylation	FDLLLSSKNGVAAFH HHHHHHCCCCHHHHH	55.11	24246443
98	S-palmitoylation	NLEFWLACEEFKKIR HHHHHHHHHHHHHHH	4.89	12642592
167	Phosphorylation	RTLMEKDSYPRFLKS CCCCCCCCCCCHHCC	48.37	26074081
168	Phosphorylation	TLMEKDSYPRFLKSP CCCCCCCCCCHHCCH	14.46	12588871
173	Ubiquitination	DSYPRFLKSPAYRDL CCCCCHHCCHHHHHH	52.24	29967540
177	Phosphorylation	RFLKSPAYRDLAAQA CHHCCHHHHHHHHHH	14.19	12588871
190	Phosphorylation	QASAASATLSSCSLD HHHHHHHHHHHCCCC	25.36	26471730
192	Phosphorylation	SAASATLSSCSLDEP HHHHHHHHHCCCCCC	25.58	26471730
193	Phosphorylation	AASATLSSCSLDEPS HHHHHHHHCCCCCCC	15.73	26471730
195	Phosphorylation	SATLSSCSLDEPSHT HHHHHHCCCCCCCCC	40.58	26471730
200	Phosphorylation	SCSLDEPSHT----- HCCCCCCCCC-----	37.40	26471730
202	Phosphorylation	SLDEPSHT------- CCCCCCCC-------	44.64	26471730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
168	Y	Phosphorylation	Kinase	EGFR	P00533	Uniprot
168	Y	Phosphorylation	Kinase	LYN	P07948	PSP
168	Y	Phosphorylation	Kinase	SRC	P12931	PSP
168	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM
177	Y	Phosphorylation	Kinase	EGFR	P00533	PhosphoELM
177	Y	Phosphorylation	Kinase	LYN	P07948	PSP
177	Y	Phosphorylation	Kinase	SRC	P12931	PSP
177	Y	Phosphorylation	Kinase	SRC64	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
2	C	Palmitoylation	-
Palmitoylated on Cys-2 and/or Cys-12.
12	C	Palmitoylation	-
Palmitoylated on Cys-2 and/or Cys-12.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RGS16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNAQ_HUMAN	GNAQ	physical	14634662
GNA13_HUMAN	GNA13	physical	14634662
GNAI3_HUMAN	GNAI3	physical	9079700
GNAI2_HUMAN	GNAI2	physical	9079700
GNAO_HUMAN	GNAO1	physical	9079700
GNAI3_HUMAN	GNAI3	physical	10072511
GNAI1_HUMAN	GNAI1	physical	10878019
GDE1_HUMAN	GDE1	physical	10760272
EGFR_HUMAN	EGFR	physical	11602604
ST14_HUMAN	ST14	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RGS16_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation."; Derrien A., Druey K.M.; J. Biol. Chem. 276:48532-48538(2001). Cited for: PHOSPHORYLATION AT TYR-168 BY EGFR, PHOSPHORYLATION AT TYR-177, ANDMUTAGENESIS OF TYR-168 AND TYR-177.	11602604 [Abstract]