dbPTM

RGL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RGL2_HUMAN
UniProt AC	O15211
Protein Name	Ral guanine nucleotide dissociation stimulator-like 2
Gene Name	RGL2
Organism	Homo sapiens (Human).
Sequence Length	777
Subcellular Localization
Protein Description	Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity)..
Protein Sequence	MLPRPLRLLLDTSPPGGVVLSSFRSRDPEEGGGPGGLVVGGGQEEEEEEEEEAPVSVWDEEEDGAVFTVTSRQYRPLDPLVPMPPPRSSRRLRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALESHPTDELERTTEVAISVLSTWLASHPEDFGSEAKGQLDRLESFLLQTGYAAGKGVGGGSADLIRNLRSRVDPQAPDLPKPLALPGDPPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLDSALESSPSLHSPADPSHLSPPASSPRPSRGHRRSASCGSPLSGGAEEASGGTGYGGEGSGPGASDCRIIRVQMELGEDGSVYKSILVTSQDKAPSVISRVLKKNNRDSAVASEYELVQLLPGERELTIPASANVFYAMDGASHDFLLRQRRRSSTATPGVTSGPSASGTPPSEGGGGSFPRIKATGRKIARALF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	PLRLLLDTSPPGGVV CEEEEECCCCCCCEE	43.00	29255136
13	Phosphorylation	LRLLLDTSPPGGVVL EEEEECCCCCCCEEE	28.85	29255136
21	Phosphorylation	PPGGVVLSSFRSRDP CCCCEEEEEECCCCC	18.80	23403867
22	Phosphorylation	PGGVVLSSFRSRDPE CCCEEEEEECCCCCC	22.10	23403867
25	Phosphorylation	VVLSSFRSRDPEEGG EEEEEECCCCCCCCC	38.74	20068231
116	Ubiquitination	TSGTDVSFMSAFLAT CCCCCHHHHHHHHHH	4.50	21906983
187	Phosphorylation	GQLDRLESFLLQTGY HHHHHHHHHHHHHCC	26.28	27499020
194	Phosphorylation	SFLLQTGYAAGKGVG HHHHHHCCCCCCCCC	9.18	27642862
198	Ubiquitination	QTGYAAGKGVGGGSA HHCCCCCCCCCCCHH	45.77	21906983
356	Phosphorylation	SSVYAVVSALQSSPI CHHHHHHHHHHCCHH	19.36	28348404
360	Phosphorylation	AVVSALQSSPIHRLR HHHHHHHCCHHHHHH	38.64	28348404
361	Phosphorylation	VVSALQSSPIHRLRA HHHHHHCCHHHHHHH	18.21	28348404
394	Phosphorylation	IFSEEDNYSQSRELL HHCCCCCCHHHHHHH	22.02	27642862
409	Phosphorylation	VQEVKLQSPLEPHSK HHHHHCCCCCCCCCC	41.72	25159151
415	Phosphorylation	QSPLEPHSKKAPRSG CCCCCCCCCCCCCCC	46.71	23403867
431	Phosphorylation	RGGGVVPYLGTFLKD CCCCCHHCHHHHHHH	13.22	-
434	Phosphorylation	GVVPYLGTFLKDLVM CCHHCHHHHHHHHHH	24.17	18491316
446	Phosphorylation	LVMLDAASKDELENG HHHHCCCCHHHHHHC	42.22	18491316
454	Phosphorylation	KDELENGYINFDKRR HHHHHHCCCCCHHHH	12.31	-
459	Ubiquitination	NGYINFDKRRKEFAV HCCCCCHHHHHHHHH	50.38	-
515	Phosphorylation	CEVEPPGSSDPPAPR EEECCCCCCCCCCCC	37.02	21815630
516	Phosphorylation	EVEPPGSSDPPAPRV EECCCCCCCCCCCCC	61.11	21815630
561	Phosphorylation	TGGDEAPTTPAPLLT CCCCCCCCCCHHHHH	53.08	25850435
562	Phosphorylation	GGDEAPTTPAPLLTR CCCCCCCCCHHHHHH	19.18	26657352
568	Phosphorylation	TTPAPLLTRLAQHMK CCCHHHHHHHHHHCC	31.18	25850435
578	Phosphorylation	AQHMKWPSVSSLDSA HHHCCCCCHHHHHHH	33.25	26657352
580	Phosphorylation	HMKWPSVSSLDSALE HCCCCCHHHHHHHHH	29.53	27732954
581	Phosphorylation	MKWPSVSSLDSALES CCCCCHHHHHHHHHH	33.76	27732954
584	Phosphorylation	PSVSSLDSALESSPS CCHHHHHHHHHHCCC	39.79	29116813
588	Phosphorylation	SLDSALESSPSLHSP HHHHHHHHCCCCCCC	48.69	27732954
589	Phosphorylation	LDSALESSPSLHSPA HHHHHHHCCCCCCCC	14.77	27732954
591	Phosphorylation	SALESSPSLHSPADP HHHHHCCCCCCCCCH	40.43	27732954
594	Phosphorylation	ESSPSLHSPADPSHL HHCCCCCCCCCHHHC	27.38	27732954
599	Phosphorylation	LHSPADPSHLSPPAS CCCCCCHHHCCCCCC	37.29	27732954
602	Phosphorylation	PADPSHLSPPASSPR CCCHHHCCCCCCCCC	24.34	25921289
606	Phosphorylation	SHLSPPASSPRPSRG HHCCCCCCCCCCCCC	46.80	27732954
607	Phosphorylation	HLSPPASSPRPSRGH HCCCCCCCCCCCCCC	27.34	27732954
611	Phosphorylation	PASSPRPSRGHRRSA CCCCCCCCCCCCCCC	52.77	29116813
617	Phosphorylation	PSRGHRRSASCGSPL CCCCCCCCCCCCCCC	25.21	23401153
619	Phosphorylation	RGHRRSASCGSPLSG CCCCCCCCCCCCCCC	21.91	23927012
622	Phosphorylation	RRSASCGSPLSGGAE CCCCCCCCCCCCCCC	27.31	23927012
625	Phosphorylation	ASCGSPLSGGAEEAS CCCCCCCCCCCCCCC	38.27	28450419
632	Phosphorylation	SGGAEEASGGTGYGG CCCCCCCCCCCCCCC	40.82	28450419
635	Phosphorylation	AEEASGGTGYGGEGS CCCCCCCCCCCCCCC	30.65	23927012
637	Phosphorylation	EASGGTGYGGEGSGP CCCCCCCCCCCCCCC	23.07	23927012
671	Phosphorylation	VYKSILVTSQDKAPS EEEEEEEECCCCCHH	19.75	29214152
672	Phosphorylation	YKSILVTSQDKAPSV EEEEEEECCCCCHHH	28.98	21815630
697	Phosphorylation	DSAVASEYELVQLLP CCCHHCHHHHHHCCC	16.45	27642862
736	Phosphorylation	LLRQRRRSSTATPGV HHHHHHHCCCCCCCC	30.17	27251789
737	Phosphorylation	LRQRRRSSTATPGVT HHHHHHCCCCCCCCC	21.90	26657352
738	Phosphorylation	RQRRRSSTATPGVTS HHHHHCCCCCCCCCC	35.48	26657352
740	Phosphorylation	RRRSSTATPGVTSGP HHHCCCCCCCCCCCC	22.21	22199227
744	Phosphorylation	STATPGVTSGPSASG CCCCCCCCCCCCCCC	33.60	22199227
745	Phosphorylation	TATPGVTSGPSASGT CCCCCCCCCCCCCCC	46.42	22199227
748	Phosphorylation	PGVTSGPSASGTPPS CCCCCCCCCCCCCCC	38.29	22199227
750	Phosphorylation	VTSGPSASGTPPSEG CCCCCCCCCCCCCCC	47.76	22199227
752	Phosphorylation	SGPSASGTPPSEGGG CCCCCCCCCCCCCCC	29.54	26657352
755	Phosphorylation	SASGTPPSEGGGGSF CCCCCCCCCCCCCCC	50.50	30175587
761	Phosphorylation	PSEGGGGSFPRIKAT CCCCCCCCCHHHHHC	35.04	25850435
768	Phosphorylation	SFPRIKATGRKIARA CCHHHHHCHHHHHHH	32.30	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
737	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RGL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RGL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAP1B_HUMAN	RAP1B	physical	8939933
CC90B_HUMAN	CCDC90B	physical	16169070
KAT5_HUMAN	KAT5	physical	16169070
KAT7_HUMAN	KAT7	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
DPYL1_HUMAN	CRMP1	physical	16169070
EF1G_HUMAN	EEF1G	physical	16169070
RAC1_HUMAN	RAC1	physical	8939933
RALA_HUMAN	RALA	physical	8939933
RASH_HUMAN	HRAS	physical	8939933
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RGL2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, AND MASSSPECTROMETRY.	18220336 [Abstract]