RFXK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RFXK_MOUSE
• UniProt AC: Q9Z205
• Protein Name: DNA-binding protein RFXANK
• Gene Name: Rfxank
• Organism: Mus musculus (Mouse).
• Sequence Length: 269
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (By similarity). May also potentiate the activation of RAF1. [PubMed: 10329666]
• Protein Sequence: MEPTQVAENLVPNQQPPVPDLEDPEDTRDESPENSDTVVLSLFPCTPDAVNPEADASASSLQGSFLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELSQLKDHLRKGACPACTCLSGNNLINKPDERGFTPLIWASAFGEIETVRFLLDWGADPHILAKERESALSLASMGGYTDIVRLLLDRDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVMESHILRLFQSTLGPVDPE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
118	Phosphorylation	KGACPACTCLSGNNL CCCCCCCCCCCCCCC	20.70	29550500
121	Phosphorylation	CPACTCLSGNNLINK CCCCCCCCCCCCCCC	41.44	29550500

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RFXK_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RFXK_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RFXK_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VAX2_MOUSE	Vax2	physical	20211142
RAF1_MOUSE	Raf1	physical	10329666
HDAC4_MOUSE	Hdac4	physical	16236793
C2TA_MOUSE	Ciita	physical	16236793

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.