RFX4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RFX4_HUMAN
• UniProt AC: Q33E94
• Protein Name: Transcription factor RFX4
• Gene Name: RFX4
• Organism: Homo sapiens (Human).
• Sequence Length: 735
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX3CL1 promoter through the X-box during brain development..
• Protein Sequence: MHCGLLEEPDMDSTESWIERCLNESENKRYSSHTSLGNVSNDENEEKENNRASKPHSTPATLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQLTTRRLGTRGQSKYHYYGIAVKESSQYYDVMYSKKGAAWVSETGKKEVSKQTVAYSPRSKLGTLLPEFPNVKDLNLPASLPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHMLPVLGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRNIKFELSRRFSQILRRQTSLNHLCQASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDEHRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSLKKVAQQFLLMWSCFGTRVIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLESLHCQERANELMRAMKGEGSTAEVREEIILTEAAAPTPSPVPSFSPAKSATSVEVPPPSSPVSNPSPEYTGLSTTGAMQSYTWSLTYTVTTAAGSPAENSQQLPCMRNTHVPSSSVTHRIPVYPHREEHGYTGSYNYGSYGNQHPHPMQSQYPALPHDTAISGPLHYAPYHRSSAQYPFNSPTSRMEPCLMSSTPRLHPTPVTPRWPEVPSANTCYTSPSVHSARYGNSSDMYTPLTTRRNSEYEHMQHFPGFAYINGEASTGWAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15 (in isoform 4)	Phosphorylation	-	48.29	-
15 (in isoform 2)	Phosphorylation	-	48.29	-
16	Phosphorylation	PDMDSTESWIERCLN CCCCCHHHHHHHHCC	33.18	23927012
30	Phosphorylation	NESENKRYSSHTSLG CHHCCCCCCCCCCCC	19.01	29083192
31	Phosphorylation	ESENKRYSSHTSLGN HHCCCCCCCCCCCCC	21.48	29083192
32	Phosphorylation	SENKRYSSHTSLGNV HCCCCCCCCCCCCCC	23.11	29083192
34	Phosphorylation	NKRYSSHTSLGNVSN CCCCCCCCCCCCCCC	27.82	29083192
35	Phosphorylation	KRYSSHTSLGNVSND CCCCCCCCCCCCCCC	28.93	29083192
40	Phosphorylation	HTSLGNVSNDENEEK CCCCCCCCCCCCHHH	42.43	26670566
127	Phosphorylation	GTRGQSKYHYYGIAV CCCCCCCCEEEEEEE	10.57	18083107
129	Phosphorylation	RGQSKYHYYGIAVKE CCCCCCEEEEEEEEE	10.57	18083107
130	Phosphorylation	GQSKYHYYGIAVKES CCCCCEEEEEEEEEC	6.69	18083107
137	Phosphorylation	YGIAVKESSQYYDVM EEEEEEECCCCEEEE	19.61	25690035
140	Phosphorylation	AVKESSQYYDVMYSK EEEECCCCEEEECCC	11.99	18083107
146	Phosphorylation	QYYDVMYSKKGAAWV CCEEEECCCCCCEEE	15.14	24719451
168	Phosphorylation	VSKQTVAYSPRSKLG CCCCEEEECCHHHHH	18.18	-
169	Phosphorylation	SKQTVAYSPRSKLGT CCCEEEECCHHHHHC	12.23	24719451
192	Phosphorylation	KDLNLPASLPEEKVS CCCCCCCCCCHHHHH	42.38	28509920
215	Phosphorylation	HCQRILDTVIRANFD HHHHHHHHHHHCCHH	17.87	-
325	Phosphorylation	QILRRQTSLNHLCQA HHHHHHHHHHHHHHH	20.88	-
333	Phosphorylation	LNHLCQASRTVIHSA HHHHHHHCCCEEEEC	11.56	-
362	Phosphorylation	LNSITKQTLYTMEDS HHHHCHHEEEECCCC	24.24	28270605
364	Phosphorylation	SITKQTLYTMEDSRD HHCHHEEEECCCCHH	13.87	28270605
365	Phosphorylation	ITKQTLYTMEDSRDE HCHHEEEECCCCHHH	19.73	28270605
578	Phosphorylation	QLPCMRNTHVPSSSV CCCCCCCCCCCCCCC	17.56	25072903
582	Phosphorylation	MRNTHVPSSSVTHRI CCCCCCCCCCCEEEE	33.87	25072903
583	Phosphorylation	RNTHVPSSSVTHRIP CCCCCCCCCCEEEEE	23.82	25072903
584	Phosphorylation	NTHVPSSSVTHRIPV CCCCCCCCCEEEEEC	35.06	25072903
642	Phosphorylation	HYAPYHRSSAQYPFN CCCCCCCCCCCCCCC	19.40	-
653	Phosphorylation	YPFNSPTSRMEPCLM CCCCCCCCCCCCCCC	32.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RFX4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RFX4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RFX4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFX2_HUMAN	RFX2	physical	11682486
RFX3_HUMAN	RFX3	physical	11682486
RFX4_HUMAN	RFX4	physical	11682486

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.