| UniProt ID | RETR1_HUMAN | |
|---|---|---|
| UniProt AC | Q9H6L5 | |
| Protein Name | Reticulophagy regulator 1 {ECO:0000312|HGNC:HGNC:25964} | |
| Gene Name | RETREG1 {ECO:0000312|HGNC:HGNC:25964} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 497 | |
| Subcellular Localization |
Golgi apparatus, cis-Golgi network membrane Multi-pass membrane protein . Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. [PubMed: 26040720 Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins] | |
| Protein Sequence | MASPAPPEHAEEGCPAPAAEEQAPPSPPPPQASPAERQQQEEEAQEAGAAEGAGLQVEEAAGRAAAAVTWLLGEPVLWLGCRADELLSWKRPLRSLLGFVAANLLFWFLALTPWRVYHLISVMILGRVIMQIIKDMVLSRTRGAQLWRSLSESWEVINSKPDERPRLSHCIAESWMNFSIFLQEMSLFKQQSPGKFCLLVCSVCTFFTILGSYIPGVILSYLLLLCAFLCPLFKCNDIGQKIYSKIKSVLLKLDFGIGEYINQKKRERSEADKEKSHKDDSELDFSALCPKISLTVAAKELSVSDTDVSEVSWTDNGTFNLSEGYTPQTDTSDDLDRPSEEVFSRDLSDFPSLENGMGTNDEDELSLGLPTELKRKKEQLDSGHRPSKETQSAAGLTLPLNSDQTFHLMSNLAGDVITAAVTAAIKDQLEGVQQALSQAAPIPEEDTDTEEGDDFELLDQSELDQIESELGLTQDQEAEAQQNKKSSGFLSNLLGGH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 26 | Phosphorylation | AEEQAPPSPPPPQAS HHHCCCCCCCCCCCC | 26471730 | ||
| 33 | Phosphorylation | SPPPPQASPAERQQQ CCCCCCCCHHHHHHH | 28634298 | ||
| 106 | Ubiquitination | FVAANLLFWFLALTP HHHHHHHHHHHHHCH | 29967540 | ||
| 149 | Phosphorylation | RGAQLWRSLSESWEV HHHHHHHHHHHHHHH | 28450419 | ||
| 151 | Phosphorylation | AQLWRSLSESWEVIN HHHHHHHHHHHHHHH | 21955146 | ||
| 153 | Phosphorylation | LWRSLSESWEVINSK HHHHHHHHHHHHHCC | 28450419 | ||
| 159 | Phosphorylation | ESWEVINSKPDERPR HHHHHHHCCCCCCCC | 23312004 | ||
| 160 | Ubiquitination | SWEVINSKPDERPRL HHHHHHCCCCCCCCH | - | ||
| 186 | Phosphorylation | SIFLQEMSLFKQQSP HHHHHHHHHHHCCCC | 24719451 | ||
| 247 | Ubiquitination | QKIYSKIKSVLLKLD HHHHHHHHHHHHHCC | 29967540 | ||
| 276 | Phosphorylation | SEADKEKSHKDDSEL CHHHHHHCCCCCHHC | 30576142 | ||
| 281 | Phosphorylation | EKSHKDDSELDFSAL HHCCCCCHHCCHHHH | 21712546 | ||
| 286 | Phosphorylation | DDSELDFSALCPKIS CCHHCCHHHHHHHHH | 30108239 | ||
| 293 | Phosphorylation | SALCPKISLTVAAKE HHHHHHHHHEEEEEE | 28555341 | ||
| 322 | Phosphorylation | DNGTFNLSEGYTPQT CCCEEECCCCCCCCC | - | ||
| 325 | Phosphorylation | TFNLSEGYTPQTDTS EEECCCCCCCCCCCC | - | ||
| 326 | Phosphorylation | FNLSEGYTPQTDTSD EECCCCCCCCCCCCC | - | ||
| 344 | Phosphorylation | RPSEEVFSRDLSDFP CCCHHHHCCCHHHCC | - | ||
| 348 | Phosphorylation | EVFSRDLSDFPSLEN HHHCCCHHHCCCCCC | - | ||
| 352 | Phosphorylation | RDLSDFPSLENGMGT CCHHHCCCCCCCCCC | 26074081 | ||
| 359 | Phosphorylation | SLENGMGTNDEDELS CCCCCCCCCCHHHHH | - | ||
| 366 | Phosphorylation | TNDEDELSLGLPTEL CCCHHHHHCCCCHHH | 24719451 | ||
| 437 | Phosphorylation | EGVQQALSQAAPIPE HHHHHHHHHCCCCCC | 24275569 | ||
| 449 | Phosphorylation | IPEEDTDTEEGDDFE CCCCCCCCCCCCCCC | 24275569 | ||
| 486 | Phosphorylation | EAQQNKKSSGFLSNL HHHHHHHHHCHHHHH | 28450419 | ||
| 487 | Phosphorylation | AQQNKKSSGFLSNLL HHHHHHHHCHHHHHH | 28464451 | ||
| 491 | Phosphorylation | KKSSGFLSNLLGGH- HHHHCHHHHHHCCC- | 28122231 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 151 | S | Phosphorylation | Kinase | CAMK2B | Q13554 | PSP |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RETR1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RETR1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| LAP4B_HUMAN | LAPTM4B | physical | 26186194 | |
| MP3B2_HUMAN | MAP1LC3B2 | physical | 26186194 | |
| LAP4B_HUMAN | LAPTM4B | physical | 28514442 | |
| MP3B2_HUMAN | MAP1LC3B2 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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