dbPTM

RDH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RDH1_HUMAN
UniProt AC	Q92781
Protein Name	11-cis retinol dehydrogenase
Gene Name	RDH5
Organism	Homo sapiens (Human).
Sequence Length	318
Subcellular Localization	Membrane Peripheral membrane protein . Endoplasmic reticulum lumen .
Protein Description	Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments. Also able to oxidize 9-cis-retinol and 13-cis-retinol, but not all-trans-retinol. Active in the presence of NAD as cofactor but not in the presence of NADP..
Protein Sequence	MWLPLLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSKFGLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNLESLEKTLQACWARLPPATQAHYGGAFLTKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVLTWVLPKPAQAVY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of RDH1_HUMAN !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RDH1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RDH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RDH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UB2G1_HUMAN	UBE2G1	physical	26186194
DDI2_HUMAN	DDI2	physical	26186194
HERC3_HUMAN	HERC3	physical	26186194
DDI2_HUMAN	DDI2	physical	28514442
GNA1_HUMAN	GNPNAT1	physical	28514442

Drug and Disease Associations

Kegg Disease
H00825	Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal la
OMIM Disease
136880	Retinitis punctata albescens (RPA)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00162	Vitamin A

Regulatory Network of RDH1_HUMAN

Related Literatures of Post-Translational Modification