RCN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RCN3_HUMAN
• UniProt AC: Q96D15
• Protein Name: Reticulocalbin-3
• Gene Name: RCN3
• Organism: Homo sapiens (Human).
• Sequence Length: 328
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Sequence: MMWRPSVLLLLLLLRHGAQGKPSPDAGPHGQGRVHQAAPLSDAPHDDAHGNFQYDHEAFLGREVAKEFDQLTPEESQARLGRIVDRMDRAGDGDGWVSLAELRAWIAHTQQRHIRDSVSAAWDTYDTDRDGRVGWEELRNATYGHYAPGEEFHDVEDAETYKKMLARDERRFRVADQDGDSMATREELTAFLHPEEFPHMRDIVIAETLEDLDRNKDGYVQVEEYIADLYSAEPGEEEPAWVQTERQQFRDFRDLNKDGHLDGSEVGHWVLPPAQDQPLVEANHLLHESDTDKDGRLSKAEILGNWNMFVGSQATNYGEDLTRHHDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	DAHGNFQYDHEAFLG CCCCCCCCCHHHHHC	18.35	-
66	Ubiquitination	FLGREVAKEFDQLTP HHCHHHHHHHHHCCH	65.18	23000965
117	Phosphorylation	QQRHIRDSVSAAWDT HHHHHHHHHHHHHHC	14.23	27251275
140	N-linked_Glycosylation	VGWEELRNATYGHYA CCHHHHHHCCCCCCC	49.62	19159218
142	O-linked_Glycosylation	WEELRNATYGHYAPG HHHHHHCCCCCCCCC	33.32	30059200
181	Phosphorylation	VADQDGDSMATREEL EECCCCCCCCCHHHH	18.82	21406692
184	Phosphorylation	QDGDSMATREELTAF CCCCCCCCHHHHHHH	29.94	21406692
200	Sulfoxidation	HPEEFPHMRDIVIAE CHHHCCCHHHHEEEC	4.13	30846556
308	Sulfoxidation	EILGNWNMFVGSQAT HHCCCCHHEECHHHC	1.86	30846556

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RCN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RCN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RCN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRUN2_HUMAN	PRUNE2	physical	16189514
HID1_HUMAN	HID1	physical	16189514
KLH42_HUMAN	KLHL42	physical	16189514
STAT6_HUMAN	STAT6	physical	21988832
PACRL_HUMAN	PACRGL	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-140, AND MASSSPECTROMETRY.
PubMed: 19159218