PRUN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRUN2_HUMAN
• UniProt AC: Q8WUY3
• Protein Name: Protein prune homolog 2
• Gene Name: PRUNE2
• Organism: Homo sapiens (Human).
• Sequence Length: 3088
• Subcellular Localization: Cytoplasm .
• Protein Description: May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells..
• Protein Sequence: MEEFLQRAKSKLNRSKRLEKVHVVIGPKSCDLDSLISTFTYAYFLDKVSPPGVLCLPVLNIPRTEFNYFTETRFILEELNISESFHIFRDEINLHQLNDEGKLSITLVGSSVLASEDKTLESAVVKVINPVEQSDANVEFRESSSSLVLKEILQEAPELITEQLAHRLRGSILFKWMTMESEKISEKQEEILSILEEKFPNLPPREDIINVLQETQFSAQGLSIEQTMLKDLKELSDGEIKVAISTVSMNLENCLFHSNITSDLKAFTDKFGFDVLILFSSYLSEEQQPRRQIAVYSENMELCSQICCELEECQNPCLELEPFDCGCDEILVYQQEDPSVTCDQVVLVVKEVINRRCPEMVSNSRTSSTEAVAGSAPLSQGSSGIMELYGSDIEPQPSSVNFIENPPDLNDSNQAQVDANVDLVSPDSGLATIRSSRSSKESSVFLSDDSPVGEGAGPHHTLLPGLDSYSPIPEGAVAEEHAWSGEHGEHFDLFNFDPAPMASGQSQQSSHSADYSPADDFFPNSDLSEGQLPAGPEGLDGMGTNMSNYSSSSLLSGAGKDSLVEHDEEFVQRQDSPRDNSERNLSLTDFVGDESPSPERLKNTGKRIPPTPMNSLVESSPSTEEPASLYTEDMTQKATDTGHMGPPQTHARCSSWWGGLEIDSKNIADAWSSSEQESVFQSPESWKEHKPSSIDRRASDSVFQPKSLEFTKSGPWESEFGQPELGSNDIQDKNEESLPFQNLPMEKSPLPNTSPQGTNHLIEDFASLWHSGRSPTAMPEPWGNPTDDGEPAAVAPFPAWSAFGKEDHDEALKNTWNLHPTSSKTPSVRDPNEWAMAKSGFAFSSSELLDNSPSEINNEAAPEIWGKKNNDSRDHIFAPGNPSSDLDHTWTNSKPPKEDQNGLVDPKTRGKVYEKVDSWNLFEENMKKGGSDVLVPWEDSFLSYKCSDYSASNLGEDSVPSPLDTNYSTSDSYTSPTFAGDEKETEHKPFAKEEGFESKDGNSTAEETDIPPQSLQQSSRNRISSGPGNLDMWASPHTDNSSEINTTHNLDENELKTEHTDGKNISMEDDVGESSQSSYDDPSMMQLYNETNRQLTLLHSSTNSRQTAPDSLDLWNRVILEDTQSTATISDMDNDLDWDDCSGGAAIPSDGQTEGYMAEGSEPETRFTVRQLEPWGLEYQEANQVDWELPASDEHTKDSAPSEHHTLNEKSGQLIANSIWDSVMRDKDMSSFMLPGSSHITDSEQRELPPEIPSHSANVKDTHSPDAPAASGTSESEALISHLDKQDTERETLQSDAASLATRLENPGYFPHPDPWKGHGDGQSESEKEAQGATDRGHLDEEEVIASGVENASGISEKGQSDQELSSLVASEHQEICIKSGKISSLAVTFSPQTEEPEEVLEYEEGSYNLDSRDVQTGMSADNLQPKDTHEKHLMSQRNSGETTETSDGMNFTKYVSVPEKDLEKTEECNFLEPENVGGGPPHRVPRSLDFGDVPIDSDVHVSSTCSEITKNLDVKGSENSLPGAGSSGNFDRDTISSEYTHSSASSPELNDSSVALSSWGQQPSSGYQEENQGNWSEQNHQESELITTDGQVEIVTKVKDLEKNRINEFEKSFDRKTPTFLEIWNDSVDGDSFSSLSSPETGKYSEHSGTHQESNLIASYQEKNEHDISATVQPEDARVISTSSGSDDDSVGGEESIEEEIQVANCHVAEDESRAWDSLNESNKFLVTADPKSENIYDYLDSSEPAENENKSNPFCDNQQSSPDPWTFSPLTETEMQITAVEKEKRSSPETGTTGDVAWQISPKASFPKNEDNSQLEMLGFSADSTEWWKASPQEGRLIESPFERELSDSSGVLEINSSVHQNASPWGVPVQGDIEPVETHYTNPFSDNHQSPFLEGNGKNSHEQLWNIQPRQPDPDADKFSQLVKLDQIKEKDSREQTFVSAAGDELTPETPTQEQCQDTMLPVCDHPDTAFTHAEENSCVTSNVSTNEGQETNQWEQEKSYLGEMTNSSIATENFPAVSSPTQLIMKPGSEWDGSTPSEDSRGTFVPDILHGNFQEGGQLASAAPDLWIDAKKPFSLKADGENPDILTHCEHDSNSQASDSPDICHDSEAKQETEKHLSACMGPEVESSELCLTEPEIDEEPIYEPGREFVPSNAELDSENATVLPPIGYQADIKGSSQPASHKGSPEPSEINGDNSTGLQVSEKGASPDMAPILEPVDRRIPRIENVATSIFVTHQEPTPEGDGSWISDSFSPESQPGARALFDGDPHLSTENPALVPDALLASDTCLDISEAAFDHSFSDASGLNTSTGTIDDMSKLTLSEGHPETPVDGDLGKQDICSSEASWGDFEYDVMGQNIDEDLLREPEHFLYGGDPPLEEDSLKQSLAPYTPPFDLSYLTEPAQSAETIEEAGSPEDESLGCRAAEIVLSALPDRRSEGNQAETKNRLPGSQLAVLHIREDPESVYLPVGAGSNILSPSNVDWEVETDNSDLPAGGDIGPPNGASKEISELEEEKTIPTKEPEQIKSEYKEERCTEKNEDRHALHMDYILVNREENSHSKPETCEERESIAELELYVGSKETGLQGTQLASFPDTCQPASLNERKGLSAEKMSSKSDTRSSFESPAQDQSWMFLGHSEVGDPSLDARDSGPGWSGKTVEPFSELGLGEGPQLQILEEMKPLESLALEEASGPVSQSQKSKSRGRAGPDAVTLQAVTHDNEWEMLSPQPVQKNMIPDTEMEEETEFLELGTRISRPNGLLSEDVGMDIPFEEGVLSPSAADMRPEPPNSLDLNDTHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDEIDINVDELDTPDEADSFEYTGHDPTANKDSGQESESIPEYTAEEEREDNRLWRTVVIGEQEQRIDMKVIEPYRRVISHGGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLYVISTLELMVAEDYMIVYLNGATPRRRMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFISSKFSSKIKYVNSLSELSGLIPMDCIHIPESIIKLDEELREASEAAKTSCLYNDPEMSSMEKDIDLKLKEKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEEFLQRA -------CHHHHHHH	46.65	22814378
9 (in isoform 5)	Phosphorylation	-	50.76	28842319
110	Phosphorylation	LSITLVGSSVLASED EEEEEECCCHHCCCC	15.14	-
171	Phosphorylation	LAHRLRGSILFKWMT HHHHHHHHHHHHHHH	15.08	26074081
178	Phosphorylation	SILFKWMTMESEKIS HHHHHHHHHCCHHHC	19.37	26074081
181	Phosphorylation	FKWMTMESEKISEKQ HHHHHHCCHHHCHHH	33.11	26074081
185	Phosphorylation	TMESEKISEKQEEIL HHCCHHHCHHHHHHH	50.21	26074081
193	Phosphorylation	EKQEEILSILEEKFP HHHHHHHHHHHHHCC	30.68	26074081
217	Phosphorylation	NVLQETQFSAQGLSI HHHHHHCCHHCCCCH	9.49	17081983
227	Phosphorylation	QGLSIEQTMLKDLKE CCCCHHHHHHHHHHH	16.22	25137130
236	Phosphorylation	LKDLKELSDGEIKVA HHHHHHCCCCCEEEE	44.66	25137130
340	Phosphorylation	YQQEDPSVTCDQVVL EECCCCCCCCCEEEE	8.21	17081983
389	Phosphorylation	SSGIMELYGSDIEPQ CCCHHHHHCCCCCCC	10.98	17081983
468	Phosphorylation	TLLPGLDSYSPIPEG CCCCCCCCCCCCCCC	32.33	24275569
470	Phosphorylation	LPGLDSYSPIPEGAV CCCCCCCCCCCCCCC	21.95	24275569
562	Phosphorylation	LSGAGKDSLVEHDEE HCCCCCCCCCCCCHH	37.49	23312004
576	Phosphorylation	EFVQRQDSPRDNSER HHHHHCCCCCCCCCC	17.31	21712546
581	Phosphorylation	QDSPRDNSERNLSLT CCCCCCCCCCCCCHH	42.07	27251275
586	Phosphorylation	DNSERNLSLTDFVGD CCCCCCCCHHHHCCC	32.54	28355574
588	Phosphorylation	SERNLSLTDFVGDES CCCCCCHHHHCCCCC	24.82	22167270
595	Phosphorylation	TDFVGDESPSPERLK HHHCCCCCCCHHHHH	35.10	30266825
597	Phosphorylation	FVGDESPSPERLKNT HCCCCCCCHHHHHCC	48.98	19664994
611	Phosphorylation	TGKRIPPTPMNSLVE CCCCCCCCCCHHHCC	29.80	29449344
615	Phosphorylation	IPPTPMNSLVESSPS CCCCCCHHHCCCCCC	27.78	29449344
619	Phosphorylation	PMNSLVESSPSTEEP CCHHHCCCCCCCCCC	39.82	26657352
620	Phosphorylation	MNSLVESSPSTEEPA CHHHCCCCCCCCCCC	14.90	26657352
622	Phosphorylation	SLVESSPSTEEPASL HHCCCCCCCCCCCHH	50.85	29449344
623	Phosphorylation	LVESSPSTEEPASLY HCCCCCCCCCCCHHC	47.99	29449344
641	Phosphorylation	MTQKATDTGHMGPPQ CCCCCCCCCCCCCCC	25.32	28555341
654	Phosphorylation	PQTHARCSSWWGGLE CCCCCCCCCCCCCCE	24.36	28857561
655	Phosphorylation	QTHARCSSWWGGLEI CCCCCCCCCCCCCEE	30.40	28857561
674	Phosphorylation	IADAWSSSEQESVFQ HHHHCCCCHHHHHHC	37.47	27732954
678	Phosphorylation	WSSSEQESVFQSPES CCCCHHHHHHCCCCH	28.11	24719451
682	Phosphorylation	EQESVFQSPESWKEH HHHHHHCCCCHHHHC	21.12	27732954
685	Phosphorylation	SVFQSPESWKEHKPS HHHCCCCHHHHCCCC	47.00	27732954
692	Phosphorylation	SWKEHKPSSIDRRAS HHHHCCCCCCCCCCC	44.74	23403867
693	Phosphorylation	WKEHKPSSIDRRASD HHHCCCCCCCCCCCC	36.72	29514088
699	Phosphorylation	SSIDRRASDSVFQPK CCCCCCCCCCCCCCC	28.71	30266825
701	Phosphorylation	IDRRASDSVFQPKSL CCCCCCCCCCCCCCE	23.49	30266825
707	Phosphorylation	DSVFQPKSLEFTKSG CCCCCCCCEEEECCC	39.55	24719451
713	Phosphorylation	KSLEFTKSGPWESEF CCEEEECCCCCCCCC	47.21	29507054
737	Phosphorylation	IQDKNEESLPFQNLP CCCCCCCCCCCCCCC	34.85	28355574
748	Phosphorylation	QNLPMEKSPLPNTSP CCCCCCCCCCCCCCC	20.54	29632367
753	Phosphorylation	EKSPLPNTSPQGTNH CCCCCCCCCCCCCCH	39.58	29632367
754	Phosphorylation	KSPLPNTSPQGTNHL CCCCCCCCCCCCCHH	23.13	29632367
758	Phosphorylation	PNTSPQGTNHLIEDF CCCCCCCCCHHHHHH	17.76	29632367
767	Phosphorylation	HLIEDFASLWHSGRS HHHHHHHHHHHCCCC	31.80	29632367
771	Phosphorylation	DFASLWHSGRSPTAM HHHHHHHCCCCCCCC	25.07	28857561
821	Phosphorylation	NTWNLHPTSSKTPSV HHHCCCCCCCCCCCC	34.58	29449344
822	Phosphorylation	TWNLHPTSSKTPSVR HHCCCCCCCCCCCCC	34.00	29449344
823	Phosphorylation	WNLHPTSSKTPSVRD HCCCCCCCCCCCCCC	42.92	29449344
825	Phosphorylation	LHPTSSKTPSVRDPN CCCCCCCCCCCCCHH	23.81	28555341
827	Phosphorylation	PTSSKTPSVRDPNEW CCCCCCCCCCCHHHH	34.71	28857561
872	Phosphorylation	WGKKNNDSRDHIFAP HCCCCCCCCCCCCCC	41.55	29449344
918	Phosphorylation	KVYEKVDSWNLFEEN HHHHCCHHHHHHHHH	22.35	28857561
1024	Phosphorylation	QSSRNRISSGPGNLD HHHHCCCCCCCCCCC	26.46	25884760
1025	Phosphorylation	SSRNRISSGPGNLDM HHHCCCCCCCCCCCC	46.78	28655764
1035	Phosphorylation	GNLDMWASPHTDNSS CCCCCCCCCCCCCCC	11.16	29449344
1038	Phosphorylation	DMWASPHTDNSSEIN CCCCCCCCCCCCCCC	40.01	29449344
1041	Phosphorylation	ASPHTDNSSEINTTH CCCCCCCCCCCCCCC	31.96	29449344
1042	Phosphorylation	SPHTDNSSEINTTHN CCCCCCCCCCCCCCC	49.07	29449344
1046	Phosphorylation	DNSSEINTTHNLDEN CCCCCCCCCCCCCHH	34.78	29449344
1047	Phosphorylation	NSSEINTTHNLDENE CCCCCCCCCCCCHHH	12.32	29449344
1096	Phosphorylation	NETNRQLTLLHSSTN HHHHCCEEEEECCCC	20.95	27732954
1100	Phosphorylation	RQLTLLHSSTNSRQT CCEEEEECCCCCCCC	38.54	27732954
1101	Phosphorylation	QLTLLHSSTNSRQTA CEEEEECCCCCCCCC	22.36	27732954
1102	Phosphorylation	LTLLHSSTNSRQTAP EEEEECCCCCCCCCC	39.98	27732954
1104	Phosphorylation	LLHSSTNSRQTAPDS EEECCCCCCCCCCCC	26.34	27732954
1111	Phosphorylation	SRQTAPDSLDLWNRV CCCCCCCCHHHHHHH	23.79	28857561
1202	Phosphorylation	HTKDSAPSEHHTLNE CCCCCCCCCCCCCCH	49.64	29514088
1206	Phosphorylation	SAPSEHHTLNEKSGQ CCCCCCCCCCHHHCH	32.94	29514088
1211	Phosphorylation	HHTLNEKSGQLIANS CCCCCHHHCHHHHHH	26.12	-
1222	Phosphorylation	IANSIWDSVMRDKDM HHHHHHHHHHCCCCC	11.65	28857561
1230	Phosphorylation	VMRDKDMSSFMLPGS HHCCCCCCCCCCCCC	30.47	28555341
1262	Phosphorylation	HSANVKDTHSPDAPA CCCCCCCCCCCCCCC	20.66	18510355
1264	Phosphorylation	ANVKDTHSPDAPAAS CCCCCCCCCCCCCCC	26.94	28355574
1271	Phosphorylation	SPDAPAASGTSESEA CCCCCCCCCCCHHHH	44.72	29514088
1273	Phosphorylation	DAPAASGTSESEALI CCCCCCCCCHHHHHH	27.16	29514088
1274	Phosphorylation	APAASGTSESEALIS CCCCCCCCHHHHHHH	42.52	27732954
1276	Phosphorylation	AASGTSESEALISHL CCCCCCHHHHHHHHH	28.12	27732954
1292	Phosphorylation	KQDTERETLQSDAAS HHHHHHHHHHHHHHH	36.00	23403867
1295	Phosphorylation	TERETLQSDAASLAT HHHHHHHHHHHHHHH	32.12	23403867
1299	Phosphorylation	TLQSDAASLATRLEN HHHHHHHHHHHHCCC	21.91	23403867
1420	Phosphorylation	RDVQTGMSADNLQPK CCCCCCCCCCCCCCC	33.54	21712546
1429	Phosphorylation	DNLQPKDTHEKHLMS CCCCCCCHHHHHHHH	37.75	28555341
1440	Phosphorylation	HLMSQRNSGETTETS HHHHHCCCCCCCCCC	39.95	28857561
1443	Phosphorylation	SQRNSGETTETSDGM HHCCCCCCCCCCCCC	33.20	29449344
1444	Phosphorylation	QRNSGETTETSDGMN HCCCCCCCCCCCCCC	32.72	17081983
1518	Phosphorylation	KNLDVKGSENSLPGA CCCCCCCCCCCCCCC	28.08	23090842
1521	Phosphorylation	DVKGSENSLPGAGSS CCCCCCCCCCCCCCC	31.71	23090842
1527	Phosphorylation	NSLPGAGSSGNFDRD CCCCCCCCCCCCCCC	34.24	28857561
1528	Phosphorylation	SLPGAGSSGNFDRDT CCCCCCCCCCCCCCC	36.52	28857561
1613	Phosphorylation	RINEFEKSFDRKTPT CHHHHHHHHCCCCCC	25.78	28857561
1618	Phosphorylation	EKSFDRKTPTFLEIW HHHHCCCCCCHHHHC	28.58	26657352
1620	Phosphorylation	SFDRKTPTFLEIWND HHCCCCCCHHHHCCC	46.19	26657352
1651	Phosphorylation	KYSEHSGTHQESNLI CCCCCCCCCCCCCCE	24.33	28555341
1655	Phosphorylation	HSGTHQESNLIASYQ CCCCCCCCCCEECHH	30.30	28555341
1670	Phosphorylation	EKNEHDISATVQPED HCCCCCCCCEECHHH	24.76	27732954
1672	Phosphorylation	NEHDISATVQPEDAR CCCCCCCEECHHHCE	16.94	27732954
1682	Phosphorylation	PEDARVISTSSGSDD HHHCEEEECCCCCCC	21.27	17081983
1683	Phosphorylation	EDARVISTSSGSDDD HHCEEEECCCCCCCC	18.78	17081983
1684	Phosphorylation	DARVISTSSGSDDDS HCEEEECCCCCCCCC	26.38	17081983
1685	Phosphorylation	ARVISTSSGSDDDSV CEEEECCCCCCCCCC	42.26	17081983
1687	Phosphorylation	VISTSSGSDDDSVGG EEECCCCCCCCCCCC	39.55	17081983
1691	Phosphorylation	SSGSDDDSVGGEESI CCCCCCCCCCCCHHH	29.65	17081983
1697	Phosphorylation	DSVGGEESIEEEIQV CCCCCCHHHHHHHHH	30.88	17081983
1719	Phosphorylation	DESRAWDSLNESNKF CHHHHHHHCCCCCCE	23.53	28857561
1723	Phosphorylation	AWDSLNESNKFLVTA HHHHCCCCCCEEEEC	44.22	28857561
1734	Phosphorylation	LVTADPKSENIYDYL EEECCCCCCCHHHHH	41.06	21082442
1738	Phosphorylation	DPKSENIYDYLDSSE CCCCCCHHHHHCCCC	15.32	25884760
1740	Phosphorylation	KSENIYDYLDSSEPA CCCCHHHHHCCCCCC	8.74	25884760
1743	Phosphorylation	NIYDYLDSSEPAENE CHHHHHCCCCCCCCC	33.72	27134283
1744	Phosphorylation	IYDYLDSSEPAENEN HHHHHCCCCCCCCCC	47.46	21712546
1788	Phosphorylation	AVEKEKRSSPETGTT HHHHHHCCCCCCCCC	62.40	27251789
1789	Phosphorylation	VEKEKRSSPETGTTG HHHHHCCCCCCCCCC	30.68	21712546
1792	Phosphorylation	EKRSSPETGTTGDVA HHCCCCCCCCCCCEE	43.12	27251789
1794	Phosphorylation	RSSPETGTTGDVAWQ CCCCCCCCCCCEEEE	34.72	27251789
1795	Phosphorylation	SSPETGTTGDVAWQI CCCCCCCCCCEEEEE	32.50	27251789
1803	Phosphorylation	GDVAWQISPKASFPK CCEEEEECCCCCCCC	12.78	21712546
1842	Phosphorylation	QEGRLIESPFERELS CCCCCCCCCCHHHCC	28.09	28355574
1849	Phosphorylation	SPFERELSDSSGVLE CCCHHHCCCCCCEEE	30.60	-
2022	Phosphorylation	TENFPAVSSPTQLIM CCCCCCCCCCCEEEE	32.48	28857561
2023	Phosphorylation	ENFPAVSSPTQLIMK CCCCCCCCCCEEEEC	25.93	28857561
2091	Phosphorylation	GENPDILTHCEHDSN CCCCCHHHHCCCCCC	25.47	-
2104	Phosphorylation	SNSQASDSPDICHDS CCCCCCCCCCCCCCH	23.21	28555341
2147	Phosphorylation	EIDEEPIYEPGREFV CCCCCCCCCCCCCCC	27.13	-
2180	Phosphorylation	YQADIKGSSQPASHK EEEECCCCCCCCCCC	22.31	29449344
2181	Phosphorylation	QADIKGSSQPASHKG EEECCCCCCCCCCCC	49.18	29449344
2185	Phosphorylation	KGSSQPASHKGSPEP CCCCCCCCCCCCCCH	32.20	29449344
2189	Phosphorylation	QPASHKGSPEPSEIN CCCCCCCCCCHHHCC	30.78	29514088
2193	Phosphorylation	HKGSPEPSEINGDNS CCCCCCHHHCCCCCC	49.82	29514088
2200	Phosphorylation	SEINGDNSTGLQVSE HHCCCCCCCCCEECC	28.70	29449344
2201	Phosphorylation	EINGDNSTGLQVSEK HCCCCCCCCCEECCC	48.44	-
2211	Phosphorylation	QVSEKGASPDMAPIL EECCCCCCCCCHHCC	30.05	22617229
2323	Phosphorylation	IDDMSKLTLSEGHPE HHHHHHCCCCCCCCC	31.79	28857561
2325	Phosphorylation	DMSKLTLSEGHPETP HHHHCCCCCCCCCCC	35.98	26657352
2331	Phosphorylation	LSEGHPETPVDGDLG CCCCCCCCCCCCCCC	32.82	28355574
2384	Phosphorylation	DPPLEEDSLKQSLAP CCCCCCCHHHHHCCC	40.52	23312004
2393	Phosphorylation	KQSLAPYTPPFDLSY HHHCCCCCCCCCHHH	24.35	28655764
2399	Phosphorylation	YTPPFDLSYLTEPAQ CCCCCCHHHCCCCCC	21.68	26657352
2432	Phosphorylation	RAAEIVLSALPDRRS HHHHHHHHHCCCCCC	19.50	28555341
2439	Phosphorylation	SALPDRRSEGNQAET HHCCCCCCCCCCCCC	51.23	28555341
2453	Phosphorylation	TKNRLPGSQLAVLHI CCCCCCCCEEEEEEE	21.78	29214152
2550	Phosphorylation	RHALHMDYILVNREE HCEEECEEEEEECCC	6.65	28674419
2571	Phosphorylation	ETCEERESIAELELY CCHHHHHHHEEEEEE	33.06	26657352
2593	Phosphorylation	LQGTQLASFPDTCQP CCCCEECCCCCCCCC	46.00	28857561
2602	Phosphorylation	PDTCQPASLNERKGL CCCCCCCCCCCCCCC	38.11	29514088
2610	Phosphorylation	LNERKGLSAEKMSSK CCCCCCCCHHHCCCC	42.95	26091039
2622	Phosphorylation	SSKSDTRSSFESPAQ CCCCCCCHHCCCCCC	41.28	28176443
2623	Phosphorylation	SKSDTRSSFESPAQD CCCCCCHHCCCCCCC	29.73	28176443
2626	Phosphorylation	DTRSSFESPAQDQSW CCCHHCCCCCCCCCE	24.43	28176443
2632	Phosphorylation	ESPAQDQSWMFLGHS CCCCCCCCEEEEECC	28.88	28176443
2639	Phosphorylation	SWMFLGHSEVGDPSL CEEEEECCCCCCCCC	31.98	28176443
2645	Phosphorylation	HSEVGDPSLDARDSG CCCCCCCCCCCCCCC	43.55	28176443
2651	Phosphorylation	PSLDARDSGPGWSGK CCCCCCCCCCCCCCC	41.14	28176443
2656	Phosphorylation	RDSGPGWSGKTVEPF CCCCCCCCCCCCCCH	36.01	28176443
2698	Phosphorylation	ASGPVSQSQKSKSRG HCCCCCHHHHHHCCC	31.88	29507054
2727	Phosphorylation	DNEWEMLSPQPVQKN CCCEEECCCCCCCCC	21.85	29449344
2860	Phosphorylation	DPTANKDSGQESESI CCCCCCCCCCCCCCC	43.94	29691806
2864	Phosphorylation	NKDSGQESESIPEYT CCCCCCCCCCCCCCC	28.85	29691806
2866	Phosphorylation	DSGQESESIPEYTAE CCCCCCCCCCCCCCH	53.36	28355574
2867 (in isoform 2)	Phosphorylation	-	2.36	29507054
2867 (in isoform 3)	Phosphorylation	-	2.36	29507054
2867 (in isoform 4)	Phosphorylation	-	2.36	29507054
2870	Phosphorylation	ESESIPEYTAEEERE CCCCCCCCCCHHHHH	13.09	29691806
2871	Phosphorylation	SESIPEYTAEEERED CCCCCCCCCHHHHHH	26.40	29691806
2945	Phosphorylation	VMENLFLYVISTLEL HHHHHHHHHHHHHHH	6.60	-
2958	Phosphorylation	ELMVAEDYMIVYLNG HHHHCCCEEEEEECC	4.73	-
2967	Phosphorylation	IVYLNGATPRRRMPG EEEECCCCCCCCCCC	20.80	-
2980	Methylation	PGLGWMKKCYQMIDR CCCHHHHHHHHHHHH	23.28	-
3047	Phosphorylation	DCIHIPESIIKLDEE HHCCCCHHHHHHCHH	25.02	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRUN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRUN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRUN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYHC1_HUMAN	DYNC1H1	physical	22863883
DC1I2_HUMAN	DYNC1I2	physical	22863883
DC1L2_HUMAN	DYNC1LI2	physical	22863883
EIF2A_HUMAN	EIF2A	physical	22863883
EIF3K_HUMAN	EIF3K	physical	22863883
RSSA_HUMAN	RPSA	physical	22863883
RS24_HUMAN	RPS24	physical	22863883
RS26_HUMAN	RPS26	physical	22863883
RS5_HUMAN	RPS5	physical	22863883
ZMYM1_HUMAN	ZMYM1	physical	28514442
FYN_HUMAN	FYN	physical	28514442
SRC_HUMAN	SRC	physical	28514442
YES_HUMAN	YES1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-576; SER-586; SER-595;SER-597 AND SER-699, AND MASS SPECTROMETRY.
PubMed: 17081983