RBG7_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RBG7_ARATH
• UniProt AC: Q03250
• Protein Name: Glycine-rich RNA-binding protein 7
• Gene Name: RBG7
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 176
• Subcellular Localization: Cytoplasm. Nucleus. Shuttling between nucleus and cytoplasm. Relocalization from the cytoplasm into the nucleus is mediated by TRN1.
• Protein Description: Plays a role in RNA transcription or processing during stress. Binds RNAs and DNAs sequence with a preference to single-stranded nucleic acids. Displays strong affinity to poly(U) and poly(G) sequence. Involved in mRNA alternative splicing of numerous targets by modulating splice site selection. Negatively regulates the circadian oscillations of its own transcript as well as RBG8 transcript. Forms an interlocked post-transcriptional negative feedback loop with the RBG8 autoregulatory circuit. Both proteins negatively autoregulate and reciprocally crossregulate by binding to their pre-mRNAs and promoting unproductive splicing coupled to degradation via the NMD pathway. Involved in the regulation of abscisic acid and stress responses. Affects the growth and stress tolerance under high salt and dehydration stress conditions, and also confers freezing tolerance, particularly via the regulation of stomatal opening and closing in the guard cells. Exhibits RNA chaperone activity during the cold adaptation process. Involved in the export of mRNAs from the nucleus to the cytoplasm under cold stress conditions. Target of the Pseudomonas syringae type III effector HopU1, which could probably be involved in plant innate immunity. Component of the flowering autonomous pathway which promotes floral transition, at least partly by down-regulating FLC..
• Protein Sequence: MASGDVEYRCFVGGLAWATDDRALETAFAQYGDVIDSKIINDRETGRSRGFGFVTFKDEKAMKDAIEGMNGQDLDGRSITVNEAQSRGSGGGGGHRGGGGGGYRSGGGGGYSGGGGSYGGGGGRREGGGGYSGGGGGYSSRGGGGGSYGGGRREGGGGYGGGEGGGYGGSGGGGGW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASGDVEYR ------CCCCCCEEE		22223895
3	Phosphorylation	-----MASGDVEYRC -----CCCCCCEEEE		25561503
49	ADP-ribosylation	DRETGRSRGFGFVTF CCCCCCCCCCEEEEE		-
49	ADP-ribosylation	DRETGRSRGFGFVTF CCCCCCCCCCEEEEE		22013065
62	Sulfoxidation	TFKDEKAMKDAIEGM EECCHHHHHHHHCCC		23289948
69	Sulfoxidation	MKDAIEGMNGQDLDG HHHHHCCCCCCCCCC		23289948
78	Phosphorylation	GQDLDGRSITVNEAQ CCCCCCCEEEEECHH		25561503
80	Phosphorylation	DLDGRSITVNEAQSR CCCCCEEEEECHHHC		28011693
86	Phosphorylation	ITVNEAQSRGSGGGG EEEECHHHCCCCCCC		19376835
105	Phosphorylation	GGGGGYRSGGGGGYS CCCCCCCCCCCCCCC		19880383
111	Phosphorylation	RSGGGGGYSGGGGSY CCCCCCCCCCCCCCC		30407730
112	Phosphorylation	SGGGGGYSGGGGSYG CCCCCCCCCCCCCCC		23776212
117	Phosphorylation	GYSGGGGSYGGGGGR CCCCCCCCCCCCCCC		30291188
118	Phosphorylation	YSGGGGSYGGGGGRR CCCCCCCCCCCCCCC		23776212
131	Phosphorylation	RREGGGGYSGGGGGY CCCCCCCCCCCCCCC		19376835
132	Phosphorylation	REGGGGYSGGGGGYS CCCCCCCCCCCCCCC		19376835
138	Phosphorylation	YSGGGGGYSSRGGGG CCCCCCCCCCCCCCC		19376835
139	Phosphorylation	SGGGGGYSSRGGGGG CCCCCCCCCCCCCCC		19376835
140	Phosphorylation	GGGGGYSSRGGGGGS CCCCCCCCCCCCCCC		19376835
159	Phosphorylation	RREGGGGYGGGEGGG CCCCCCCCCCCCCCC		24243849
167	Phosphorylation	GGGEGGGYGGSGGGG CCCCCCCCCCCCCCC		22440515
170	Phosphorylation	EGGGYGGSGGGGGW- CCCCCCCCCCCCCC-		30589143

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RBG7_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RBG7_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RBG7_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBG7_ARATH	CCR2	physical	17924945
RBG8_ARATH	CCR1	physical	17924945
RBG7_ARATH	CCR2	physical	18576621
CADH5_ARATH	CAD5	physical	21798944
JAC1_ARATH	JAC1	physical	26392261

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.