RBG8_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RBG8_ARATH
• UniProt AC: Q03251
• Protein Name: Glycine-rich RNA-binding protein 8
• Gene Name: RBG8
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 169
• Subcellular Localization: Cytoplasm . Nucleus. Shuttling between nucleus and cytoplasm. Relocalization from the cytoplasm into the nucleus is mediated by TRN1 (By similarity)..
• Protein Description: Plays a role in RNA transcription or processing during stress. Binds RNAs and DNAs sequence with a preference to single-stranded nucleic acids. Involved in mRNA alternative splicing of numerous targets by modulating splice site selection. Negatively regulates the circadian oscillations of its own transcript as well as RBG7 transcript. Forms an interlocked post-transcriptional negative feedback loop with the RBG7 autoregulatory circuit. Both proteins negatively autoregulate and reciprocally crossregulate by binding to their pre-mRNAs and promoting unproductive splicing coupled to degradation via the NMD pathway. Target of the Pseudomonas syringae type III effector HopU1..
• Protein Sequence: MSEVEYRCFVGGLAWATNDEDLQRTFSQFGDVIDSKIINDRESGRSRGFGFVTFKDEKAMRDAIEEMNGKELDGRVITVNEAQSRGSGGGGGGRGGSGGGYRSGGGGGYSGGGGGGYSGGGGGGYERRSGGYGSGGGGGGRGYGGGGRREGGGYGGGDGGSYGGGGGGW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	EDLQRTFSQFGDVID HHHHHHHHHHHHHHH		19880383
47	ADP-ribosylation	DRESGRSRGFGFVTF CCCCCCCCCCCEEEE		-
47	ADP-ribosylation	DRESGRSRGFGFVTF CCCCCCCCCCCEEEE		-
67	Sulfoxidation	MRDAIEEMNGKELDG HHHHHHHHCCCCCCC		23289948
84	Phosphorylation	ITVNEAQSRGSGGGG EEEECCHHCCCCCCC		19376835
103	Phosphorylation	GSGGGYRSGGGGGYS CCCCCCCCCCCCCCC		30291188
109	Phosphorylation	RSGGGGGYSGGGGGG CCCCCCCCCCCCCCC		23776212
110	Phosphorylation	SGGGGGYSGGGGGGY CCCCCCCCCCCCCCC		23776212
117	Phosphorylation	SGGGGGGYSGGGGGG CCCCCCCCCCCCCCC		23776212
118	Phosphorylation	GGGGGGYSGGGGGGY CCCCCCCCCCCCCCC		30291188
154	Phosphorylation	GRREGGGYGGGDGGS CCCCCCCCCCCCCCC		22440515
161	Phosphorylation	YGGGDGGSYGGGGGG CCCCCCCCCCCCCCC		30291188
162	Phosphorylation	GGGDGGSYGGGGGGW CCCCCCCCCCCCCCC		22440515

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RBG8_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RBG8_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RBG8_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBG8_ARATH	CCR1	physical	18987006
RBG7_ARATH	CCR2	physical	18987006

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.