QORX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: QORX_HUMAN
• UniProt AC: Q53FA7
• Protein Name: Quinone oxidoreductase PIG3
• Gene Name: TP53I3
• Organism: Homo sapiens (Human).
• Sequence Length: 332
• Protein Description: May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro)..
• Protein Sequence: MLAVHFDKPGGPENLYVKEVAKPSPGEGEVLLKVAASALNRADLMQRQGQYDPPPGASNILGLEASGHVAELGPGCQGHWKIGDTAMALLPGGGQAQYVTVPEGLLMPIPEGLTLTQAAAIPEAWLTAFQLLHLVGNVQAGDYVLIHAGLSGVGTAAIQLTRMAGAIPLVTAGSQKKLQMAEKLGAAAGFNYKKEDFSEATLKFTKGAGVNLILDCIGGSYWEKNVNCLALDGRWVLYGLMGGGDINGPLFSKLLFKRGSLITSLLRSRDNKYKQMLVNAFTEQILPHFSTEGPQRLLPVLDRIYPVTEIQEAHKYMEANKNIGKIVLELPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	VKEVAKPSPGEGEVL EEEEECCCCCCCHHH	44.84	28857561
85	Phosphorylation	GHWKIGDTAMALLPG CCCEECCEEEEECCC	17.08	-
100	Phosphorylation	GGQAQYVTVPEGLLM CCCCEEEECCCCCEE	25.96	-
171	Phosphorylation	AGAIPLVTAGSQKKL HCCCCEEECCCHHHH	32.74	21406692
174	Phosphorylation	IPLVTAGSQKKLQMA CCEEECCCHHHHHHH	36.04	21406692
176	2-Hydroxyisobutyrylation	LVTAGSQKKLQMAEK EEECCCHHHHHHHHH	58.09	-
176	Malonylation	LVTAGSQKKLQMAEK EEECCCHHHHHHHHH	58.09	26320211
180	Sulfoxidation	GSQKKLQMAEKLGAA CCHHHHHHHHHHCCC	8.24	30846556
193	2-Hydroxyisobutyrylation	AAAGFNYKKEDFSEA CCCCCCCCCCCCCHH	51.28	-
194	Ubiquitination	AAGFNYKKEDFSEAT CCCCCCCCCCCCHHH	52.75	-
194	Malonylation	AAGFNYKKEDFSEAT CCCCCCCCCCCCHHH	52.75	26320211
203	Ubiquitination	DFSEATLKFTKGAGV CCCHHHHHHCCCCCC	46.78	-
252	Phosphorylation	DINGPLFSKLLFKRG CCCCHHHHHHHHHHC	30.03	24719451
260	Phosphorylation	KLLFKRGSLITSLLR HHHHHHCHHHHHHHH	22.19	23927012
263	Phosphorylation	FKRGSLITSLLRSRD HHHCHHHHHHHHCCC	20.72	23927012
264	Phosphorylation	KRGSLITSLLRSRDN HHCHHHHHHHHCCCH	20.57	23927012
321	Acetylation	HKYMEANKNIGKIVL HHHHHHCCCCCCHHC	57.92	19608861
321	Malonylation	HKYMEANKNIGKIVL HHHHHHCCCCCCHHC	57.92	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of QORX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of QORX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of QORX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FUND2_HUMAN	FUNDC2	physical	16169070
EF1G_HUMAN	EEF1G	physical	16169070
UBR1_HUMAN	UBR1	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
H2AX_HUMAN	H2AFX	physical	20023697
TP53B_HUMAN	TP53BP1	physical	20023697
HEM3_HUMAN	HMBS	physical	26344197
GPX3_HUMAN	GPX3	physical	22461624

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-321, AND MASS SPECTROMETRY.
PubMed: 19608861