dbPTM

GPX3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GPX3_HUMAN
UniProt AC	P22352
Protein Name	Glutathione peroxidase 3
Gene Name	GPX3
Organism	Homo sapiens (Human).
Sequence Length	226
Subcellular Localization	Secreted.
Protein Description	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione..
Protein Sequence	MARLLQASCLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYAGKYVLFVNVASYUGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWHHRTTVSNVKMDILSYMRRQAALGVKRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	IYEYGALTIDGEEYI EEEEECEEECCEEEE	19.25	-
59	Phosphorylation	EYIPFKQYAGKYVLF EEEEHHHHCCEEEEE	20.22	-
155	Phosphorylation	FYTFLKNSCPPTSEL HHHHHHCCCCCHHHH	26.81	25850435
159	Phosphorylation	LKNSCPPTSELLGTS HHCCCCCHHHHCCCC	21.70	25850435
160	Phosphorylation	KNSCPPTSELLGTSD HCCCCCHHHHCCCCC	31.83	25850435
165	Phosphorylation	PTSELLGTSDRLFWE CHHHHCCCCCCCCCC	27.68	25850435
166	Phosphorylation	TSELLGTSDRLFWEP HHHHCCCCCCCCCCC	20.95	25850435

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GPX3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GPX3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GPX3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GPX3_HUMAN	GPX3	physical	3693360
UBQL1_HUMAN	UBQLN1	physical	25416956
QORX_HUMAN	TP53I3	physical	22461624

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GPX3_HUMAN

Related Literatures of Post-Translational Modification