PYM_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PYM_DROME
• UniProt AC: P82804
• Protein Name: Partner of Y14 and mago {ECO:0000312|FlyBase:FBgn0034918}
• Gene Name: Pym {ECO:0000312|FlyBase:FBgn0034918}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 207
• Subcellular Localization: Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by emb/Crm1.
• Protein Description: Regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor by disrupting mature EJC from spliced mRNAs. Required for normal localization of osk mRNA to the posterior pole of the developing oocyte. Does not interact with the small ribosomal unit or components of the translation initiation complex. May not function in cap-dependent translation regulation..
• Protein Sequence: MSTYLQSSEGKFIPATKRPDGTWRKARRVKDGYVPQEEVPLYESKGKQFVAQRQAGVPPGMCPLLAAESKKEREKQERTRAKKQEKESGRQPKAPAPGVLVMPPSTCPPPKVSQQQQQQQQQPSGSRDINSISKTLEDTLKLDAAQEVVDPAKQLKKLRKKIREIEQIESRIQAGEQKKLDKDQLDKVKKKSEILRQIKDLESTPRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	ATKRPDGTWRKARRV CCCCCCCCCEEEECC		22817900
42	Phosphorylation	PQEEVPLYESKGKQF CHHHCCCCCCCCHHH		19429919
44	Phosphorylation	EEVPLYESKGKQFVA HHCCCCCCCCHHHHH		19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PYM_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PYM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PYM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BGCN_DROME	bgcn	genetic	24967911
RBM8A_DROME	tsu	physical	14968132
RBM8A_DROME	tsu	physical	24967911
MGN_DROME	mago	physical	14968132
MGN_DROME	mago	physical	24967911

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.