dbPTM

BGCN_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BGCN_DROME
UniProt AC	Q9W1I2
Protein Name	Benign gonial cell neoplasm protein
Gene Name	bgcn
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1215
Subcellular Localization
Protein Description	Essential cystoblast differentiation factor required for Bam function in asymmetric division of the germline stem cells..
Protein Sequence	MNHIIQDKYIPQQLLYFLAGRRCCQQFPCTFRTSEHEAFANNARSLGLRSQVVHVNGNSCVKVYKQACRHYLEEPKTLVLSSGATLNMFTLLSRKSLMGKEDLELYADLVSMKANASDLPSLHLPLPAIRPPNLRFWTEAQLNFLTAFLGHSLSDEILQSLYASRVIVYNAALCWDKSVFLPLVILDDCRNKKSNVKIMCIERQAILATYNSQRTANFFGEQLGETVGIQLPYFSAVSSSTFIIYSTAQYFLRSLTSQQFRNISHLVVNDVHLHDPYTDILLSEIRMALSSHQNLRVVLLSQMGNPKKFTDFFGEGLQLNMIKQPEVAPRVSYLNELHSCIALAGIHKGPDIYKEIPEAFRANNPRNEQMDKCLQAYGELGTDAALRPFLYAVNYDLAPVNYRHSLTGKTAVHFASELNKANHLRLLLFMGADPYIVDLFQQNAISLAAMNGNHECIDVLNSYSLHGYVVKSAKPDFVDYDLIIDIMYLLRTKPEYSPGEYSPGNILIILPTYYHIVKLNYMILSHCLTGSLQECSIFLLYDNMRNDYLQALVNASDETVKVVLATDIIESLCLKVPFKYQIDTACRLNNVYDTTSCSGDDRFEWVAKDALLRRELILQPNKGDVQCFRLISKEAYEELSETSQPSLQTMQLDKICLAVKLLSPNTIISEYLGITISPPPLINVHHAVQFLKKIDVLDDAEDVTWLGCRLMDIPVSCQLGRMLIFGILLRCLDPILTIVSSLSTADPLGIPFTEDIDNLWDRFTIYIQNSIKKERTYLSDNQFSDHFIFVRLYKEWQNRMHNRTPPLYLKDEYEFMLNGLMEQLTSIRSEIVSSLRAANLIHSRGKLSMNNLNQMSCNWHMVKAALTGGMYPNIYAVDTRKSSLKSAFSGNVSMHPNTVLRDFLEPLNISAQSFRTPWIVCNRQKSHIVYATLVVPLAVAMFSGHPRIRLSPICDSEMSLTDRNVNVFIDEWIWMVMSKATAEMVMRTRYYFFKMYHDLLKHCSELDMWRRDCEPVSQYTVLTDTLSKIFESEDGFVGFFKPPPITFLPTPQLPSLYLLSVNAHFSWAREVEENMLSKPHHFNSHFIERQFFVLYAGGDCEEFHSRNTPAFIESVLGKFVRPIDTPNRHIFVILYRKDPDMMLSISRAKFVNGVFMLQEYFRNNIPVFEILDACVSLNVQTPVFDGRLMSALIDKRVGNLIMELFAFRHHWIHKR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
898	Phosphorylation	NVSMHPNTVLRDFLE CCCCCCCCCHHHHHH	25.93	18327897
1144	Phosphorylation	KDPDMMLSISRAKFV CCHHHCCEEHHHHHH	10.71	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BGCN_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BGCN_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BGCN_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SETB1_DROME	egg	genetic	22216012
CADE_DROME	shg	genetic	18371420
INX4_DROME	zpg	genetic	14660550
SXL_DROME	Sxl	physical	23526974
BAM_DROME	bam	physical	19470484
BAM_DROME	bam	physical	19556547
BAM_DROME	bam	physical	23122292
BAM_DROME	bam	physical	25412508
BAM_DROME	bam	physical	26291077
BAM_DROME	bam	physical	23526974

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BGCN_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-898, AND MASSSPECTROMETRY.	18327897 [Abstract]